Abstract
A 33-amino acid peptide corresponding to the helix-loop-helix motif of the calcium binding site I of the protein calmodulin from Paramecium Tetraurelia has been synthesized its binding properties with heavy metal ions have been studied. Herein, we demonstrate that two mutations of two aspartic acid residues in the peptide sequence gave access to a new peptide, which was selective for the uranyl ion UO2 2+. This new peptide can be useful for the development of selective uranyl biosensors to monitor the presence of uranium in contaminated environments.
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We wish to thank the Nuclear Toxicology Program of the Commissariat à l’Energie Atomique for financial support
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Le Clainche, L., Vita, C. Selective binding of uranyl cation by a novel calmodulin peptide. Environ Chem Lett 4, 45–49 (2006). https://doi.org/10.1007/s10311-005-0033-y
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DOI: https://doi.org/10.1007/s10311-005-0033-y