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New potential mammalian lignan metabolites of environmental phytoestrogens

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Abstract

Seven new dibenzylbutyrolactone and six new dibenzylbutanediol lignans were prepared to assist in the identification of a number of potential mammalian metabolites of the endocrine disrupting plant lignans syringaresinol and medioresinol, present in food.

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Acknowledgments

We thank Dr Jorma Matikainen for running the mass spectra and Ms Nina Matikainen for skillful technical assistance. Funding from Finnish Academy (78253, 210633), Research Funds of University of Helsinki, Chancellor of University of Helsinki and the Graduate School of Bio-organic and Medicinal Chemistry is gratefully acknowledged. B.R. thanks Magnus Ehrnrooth Foundation for financial support. This work was partially carried out within the EU project PHYTOHEALTH no QLRT-2001-02453. This study does not necessarily reflect the views of the Commission and in no way anticipates the Commission's future policy in this area

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Authors and Affiliations

  1. Department of Chemistry, Organic Chemistry Laboratory, University of Helsinki, P.O. Box 55, 00014, Helsinki, Finland

    Barbara Raffaelli, Eija Leppälä, Clément Chappuis & Kristiina Wähälä

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  1. Barbara Raffaelli
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  2. Eija Leppälä
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  3. Clément Chappuis
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  4. Kristiina Wähälä
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Correspondence to Kristiina Wähälä.

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Raffaelli, B., Leppälä, E., Chappuis, C. et al. New potential mammalian lignan metabolites of environmental phytoestrogens. Environ Chem Lett 4, 1–9 (2006). https://doi.org/10.1007/s10311-005-0011-4

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  • DOI: https://doi.org/10.1007/s10311-005-0011-4

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