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Degradation of hydrochlorothiazide in water

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Abstract

The photolytic decomposition of hydrochlorothiazide in water was investigated. Irradiation of the drug was performed in pure water and sewage treatment plant water with a solar simulator and by direct sunlight. Here we show that three photoproducts were obtained. Two of them were formed in yields much higher than 10%. An environmental risk assessment of hydrochlorothiazide should take into account also these photoproducts in a complete analytical and ecotoxicological evaluation.

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Acknowledgements

This work was supported by MIUR (Ministero Istruzione Università e Ricerca) in the frame of PRIN 2002 (Progetto Ricerca Interesse Nazionale). NMR experiments were performed at CIMCF (Centro Interdipartimentale di metodologie chimico-fisiche) on a Varian 500 Inova spectrometer of Consortium INCA (Interuniversitario Nazionale Consorzio Ambiente) (Cluster 11-A, Project P0, L.488). The authors wish also to thank Dr. G. Giacometti.

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Authors and Affiliations

  1. Dipartimento di Scienze della Vita, II Università di Napoli, Via Vivaldi 43, I-81100, Caserta, Italy

    M. Brigante

  2. Dipartimento di Chimica Organica e Biochimica, Università Federico II, Via Cinthia 4, I-80126, Naples, Italy

    M. DellaGreca, L. Previtera, M. Rubino & F. Temussi

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  1. M. Brigante
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  2. M. DellaGreca
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  3. L. Previtera
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  4. M. Rubino
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  5. F. Temussi
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Correspondence to F. Temussi.

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Brigante, M., DellaGreca, M., Previtera, L. et al. Degradation of hydrochlorothiazide in water. Environ Chem Lett 2, 195–198 (2005). https://doi.org/10.1007/s10311-004-0096-1

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  • DOI: https://doi.org/10.1007/s10311-004-0096-1

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