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Tiermodelle der mesialen Temporallappenepilepsie

Animal models of mesial temporal lobe epilepsy

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Zusammenfassung

Tiermodelle sind in der experimentellen Epilepsieforschung noch immer unverzichtbar, um Beschränkungen in klinischer Forschung zu umgehen. Modelle der mesialen Temporallappenepilepsie (mTLE) sollten phänotypische und pathophysiologische Kriterien der Erkrankung replizieren. Am häufigsten verwendet werden mTLE-Modelle nach chemokonvulsiv oder elektrisch induziertem Status epilepticus in Nagetieren. Kenntnisse von Validitätskriterien und Beschränkungen dieser und anderer Modelle sind die Grundlage der Einordnung tierexperimenteller Befunde und werden in dieser Übersicht vorgestellt.

Abstract

Animal models are still indispensable in experimental epilepsy research in order to overcome restrictions in clinical research. Models of mesial temporal lobe epilepsy (mTLE) aim to replicate phenotypic and pathophysiological criteria of the disease. The mTLE models following chemoconvulsive or electrically induced status epilepticus in rodents are used most frequently. Knowledge of validity criteria and limitations of these and other models are the basis for the classification of animal experimental findings and are presented in this overview.

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Abb. 1

Abbreviations

FCD:

Fokale kortikale Dysplasie

HFO:

High frequency oscillations HS Hippocampussklerose

ILAE:

International League Against Epilepsy

(m)TLE:

(Mesiale) Temporallappenepilepsie

nb:

Nicht bekannt

PET:

Positronenemissionstomographie

PPS:

Perforant pathway stimulation (Tractus-perforans-Stimulation)

SE:

Status epilepticus

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Förderung

Diese Arbeit wurde vom Land Hessen mit Mitteln aus dem LOEWE-Programm an das CePTER-Konsortium unterstützt.

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  1. Epilepsiezentrum Frankfurt Rhein-Main, Klinik für Neurologie, Universitätsklinikum Frankfurt, Goethe-Universität Frankfurt, Schleusenweg 2–16, 60528, Frankfurt, Deutschland

    Sebastian Bauer

  2. LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-Universität Frankfurt, Frankfurt am Main, Deutschland

    Sebastian Bauer

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Für diesen Beitrag wurden vom Autor keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Bauer, S. Tiermodelle der mesialen Temporallappenepilepsie. Z. Epileptol. 33, 62–69 (2020). https://doi.org/10.1007/s10309-019-00301-y

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