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Dynamic imaging of coherent sources

Identification of neuronal networks underlying frequency-associated EEG patterns

Dynamische Bildgebung von kohärenten Quellen

Darstellung neuronaler Netzwerke bei frequenzspezifischen EEG Mustern

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Abstract

Electric source imaging allows localization of sources in the brain underlying frequency-associated EEG patterns detected on the scalp EEG. New algorithms have substantially improved the localization power of the EEG. Dynamic imaging of coherent sources (DICS) is one of these solutions. This algorithm uses a spatial filter to map power and coherence estimates of oscillatory brain activity. In this focus article, we explain the DICS method and summarize studies representing the ability of DICS to detect cortical and subcortical electric sources and neuronal networks associated with absence seizures, photoparoxysmal responses and hypsarrhythmia. By applying renormalized partial directed coherence (RPDC), the information flow between 2 sources can be described, which contributes to a better understanding of networks underlying different forms of epilepsy.

Zusammenfassung

Die elektrische Quellenbildgebung erlaubt die Lokalisation von Ursprungsorten im Gehirn, die mit frequenzspezifischen EEG-Mustern assoziiert sind. Neue Algorithmen haben dieses Lokalisationsvermögen substanziell verbessert. Die dynamische Bildgebung von kohärenten Quellen („dynamic imaging of coherent sources“, DICS) ist ein solcher Algorithmus: Das DICS verwendet einen räumlichen Filter, um „power“ und Kohärenz der oszillatorischen Hirnaktivität darzustellen. Im vorliegenden Übersichtsbeitrag wird die DICS-Methode erläutert, und DICS-Studien im Bereich der Epileptologie werden zusammengefasst: Studien zu Absencen, fotoparoxysmaler Reaktion und Hypsarrhythmie demonstrieren, dass mithilfe des DICS kortikale und subkortikale elektrische Quellen und somit neuronale Netzwerke detektiert werden können. Darüber hinaus ermöglicht die normierte partiell-gerichtete Kohärenzanalyse („renormalized partial directed coherence“, RPDC), die Richtung des Informationsflusses zwischen 2 Quellen zu beschreiben und infolgedessen die zugrunde liegenden epileptischen Netzwerke besser zu verstehen.

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Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.

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Authors and Affiliations

  1. Clinic for Child Neurology, Department of Neuropediatrics, Christian-Albrechts-University of Kiel, Schwanenweg 20, 24105, Kiel, Germany

    N. Japaridze, U. Stephani &  F. Moeller

  2. University Hospital of Child and Adolescent Psychiatry, Johann Wolfgang Goethe-University of Frankfurt, Deutschordenstr. 50, 60528, Frankfurt am Main, Germany

    M. Siniatchkin

  3. Department of Neurology, Christian-Albrechts-University of Kiel, Schittenhelmstr. 10, 24105, Kiel, Germany

    M. Muthuraman & J. Raethjen

Authors
  1. N. Japaridze
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  2. M. Siniatchkin
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  3. M. Muthuraman
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  4. J. Raethjen
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  5. U. Stephani
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  6. F. Moeller
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Correspondence to F. Moeller.

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Japaridze, N., Siniatchkin, M., Muthuraman, M. et al. Dynamic imaging of coherent sources. Z. Epileptol. 26, 19–24 (2013). https://doi.org/10.1007/s10309-012-0292-0

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