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Opioidrezeptoragonisten

Antiepileptika der Zukunft?

Opioid receptor agonists

Antiepileptics of the future?

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Zusammenfassung

Zur Gruppe der endogenen Opioide gehören β-Endorphin, Metenzephalin, Leuenzephalin und die Dynorphine. Die Vorläuferpeptide der Opioide werden von 3 unterschiedlichen Genen codiert. Durch Spaltung der Vorläuferpeptide entstehen aktive Neuropeptide, die bei hochfrequenter Entladung, z. B. im Rahmen eines epileptischen Anfalls, freigesetzt werden. Sie wirken über prä- und postsynaptisch lokalisierte µ-, δ- und κ-Opioid-Rezeptoren. Die Wirkung der einzelnen Opioide hängt von ihrer unterschiedlichen Affinität und Selektivität für Opioidrezeptoren ab. Ziele dieses Übersichtsbeitrags sind die Darstellung möglicher Rollen dieser Peptide in der Epileptogenese und Überlegungen zum therapeutischen Einsatz von Substanzen, die über Opioidrezeptoren wirken.

Abstract

The group of endogenous opioids comprise β-endorphin, met-enkephalin, leu-enkephalin, and dynorphins. Opioid precursor proteins are encoded by three different genes. Precursor proteins are processed to biological active neuropeptides. These neuropeptides are released upon high frequency stimulation, e.g. during an epileptic seizure. Endogenous opioids bind to pre- and postsynaptic localized µ-, δ-, and κ-receptors. Depending on the opioid receptor selectivity and affinity, neuropeptides bear different functions. The aim of this review is to elucidate the possible role of endogenous opioids in epileptogenesis and to discuss pro- and anticonvulsive functions of opioid receptor agonists and antagonists.

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  1. 2. Neurologische Abteilung , Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel und Karl Landsteiner Institut für Klinische Epilepsieforschung und Kognitive Neurologie, Riedelgasse 5, 1130, Wien, Österreich

    S. Pirker & C. Baumgartner

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  1. S. Pirker
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  2. C. Baumgartner
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Correspondence to S. Pirker.

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Pirker, S., Baumgartner, C. Opioidrezeptoragonisten. Z. Epileptol. 25, 36–40 (2012). https://doi.org/10.1007/s10309-011-0218-2

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  • DOI: https://doi.org/10.1007/s10309-011-0218-2

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