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Genetische Disposition zu Fieberkrämpfen

Genetic predisposition to febrile seizures

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Zusammenfassung

Fieberkrämpfe gehen in ca. 10–15% der Fälle idiopathischen Epilepsien voraus. Bei Geschwistern beträgt das familiäre Wiederholungsrisiko ca. 15%. Die Disposition zu Fieberkrämpfen folgt einem komplexen Vererbungsmuster mit mehreren beteiligten Genen. Das SCN1A-Gen, das für den spannungsabhängigen Natriumkanal NaV1.1 kodiert, scheint hier die größte Bedeutung zu haben und könnte für bis zu 50% der genetischen Komponente verantwortlich sein.

Abstract

Febrile seizures antecede idiopathic epilepsies in about 10–15% of cases. In siblings of index cases with febrile seizures, the recurrence risk is about 15%. The genetic predisposition follows a complex mode of inheritance, with several affected genes. The most important gene seems to be SCN1A, coding for the NaV1.1 sodium channel. Defects and polymorphisms in SCN1A may account for up to 50% of the genetic impact.

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Authors and Affiliations

  1. Abteilung Neuropädiatrie, Sozialpädiatrie und Epileptologie, Univ. Klinikum Gießen – Marburg, Univ. Kinderklinik Gießen, Feulgenstr. 12, 35392, Gießen, Deutschland

    B.A. Neubauer

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  1. B.A. Neubauer
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Correspondence to B.A. Neubauer.

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Neubauer, B. Genetische Disposition zu Fieberkrämpfen. Z. Epileptol. 22, 213–215 (2009). https://doi.org/10.1007/s10309-009-0063-8

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  • DOI: https://doi.org/10.1007/s10309-009-0063-8

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