Skip to main content
Log in

Antiepileptika und Hormone bei Frauen

Antiepileptic drugs and hormones in women

  • BEITRAG ZUM THEMENSCHWERPUNKT
  • Published:
Zeitschrift für Epileptologie Aims and scope Submit manuscript

Abstract

This review summarises the literature on the relationships between seizures, antiepileptic drugs and hormones in women with epilepsy, including the influence of sexual hormones on seizure threshold, hormonal abnormalities in women with epilepsy and their etiology, and the frequency of seizures during pregnancy with various antiepileptic drugs.

Zusammenfassung

Der aktuelle Wissensstand zu den Beziehungen zwischen Epilepsie,Hormonen und Anfallsaktivität wird zusammengefasst. Behandelt wird der Einfluss der weiblichen Sexualhormone auf die Anfallsschwelle, hormonelle Störungen bei epilepsiekranken Frauen und deren Ätiologie, sowie neue Beobachtungen zur Anfallsaktivität in der Schwangerschaft in Abhängigkeit von der antiepileptischen Medikation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Baird AD, Wilson SJ, Bladin PF, Saling MM, Reutens DC (2003) Sexual outcome after epilepsy surgery. Epilepsy Behav 4:268–278

    Article  PubMed  Google Scholar 

  2. Bauer J, Jarre A, Klingmuller D, Elger CE (2000) Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res 41:163–167

    Article  PubMed  CAS  Google Scholar 

  3. Bergen D, Daugherty S, Eckenfels E (1992) Reduction of sexual activities in females taking antepileptic drugs. Psychopathology 25:1–4

    Article  PubMed  CAS  Google Scholar 

  4. Bilo L, Meo R, Nappi C, Annunziato L, Striano S, Colao AM, Merola B, Buscaino GA (1988) Reproductive endocrine disorders in women with primary generalized epilepsy. Epilepsia 29:612–619

    PubMed  CAS  Google Scholar 

  5. Cummings LN, Giudice L, Morrell MJ (1995) Ovulatory function in epilepsy. Epilepsia 36:355–359

    Article  PubMed  CAS  Google Scholar 

  6. Daniele A, Azzoni A, Bizzi A, Rossi A, Gainotti G (1997) Mazza S. Sexual behavior and hemispheric laterality of the focus in patients with temporal lobe epilepsy. Biol Psychiatry 42:617– 624

    Article  PubMed  CAS  Google Scholar 

  7. Duncan S, Blacklaw J, Beastall GH, Brodie MJ (1997) Sexual function in women with epilepsy. Epilepsia 38:1074–1081

    Article  PubMed  CAS  Google Scholar 

  8. EURAP Study Group (2006) Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology 14:354–360

    Google Scholar 

  9. Fenwick PB, Toone BK, Wheeler MJ, Nanjee MN, Grant R, Brown D (1985) Sexual behaviour in a centre for epilepsy. Acta Neurol Scand 71:428–435

    Article  PubMed  CAS  Google Scholar 

  10. Gaus V, Coban I, Kretz R, Schmitz B (2005) EURAP – Anfallskontrolle in der Schwangerschaft unter Lamotrigin, Carbamazepin und Valproat in Monotherapie. Z Epileptol 18:129 (Abstract)

    Google Scholar 

  11. Harden CL, Koppel BS, Herzog AG, Nikolov BG, Hauser WA (2003) Seizure frequency is associated with age at menopause in women with epilepsy. Neurology 61:451–455

    PubMed  CAS  Google Scholar 

  12. Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW, Ransil BJ, Schomer DL (2003) Interictal EEG discharges, reproductive hormones, and menstrual disorders in epilepsy. Ann Neurol 54:625–637

    Article  PubMed  Google Scholar 

  13. Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N (1986) Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 43:341–346

    PubMed  CAS  Google Scholar 

  14. Herzog AG, Seibel MM, Schomer D, Vaitukaitis J, Geschwind N (1984) Temporal lobe epilepsy: an extrahypothalamic pathogenesis for polycystic ovarian syndrome? Neurology 34:1389–1393

    PubMed  CAS  Google Scholar 

  15. Herzog AG (1993) A relationship between particular reproductive endocrine disorders and the laterality of epileptiform discharges in women with epilepsy. Neurology 43:1907–1910

    PubMed  CAS  Google Scholar 

  16. Isojarvi JI, Laatikainen TJ, Pakarinen AJ, Juntunen KT, Myllyla VV (1993) Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med 329:1383–1388

    Article  PubMed  CAS  Google Scholar 

  17. Isojarvi JI, Laatikainen TJ, Knip M, Pakarinen AJ, Juntunen KT, Myllyla VV (1996) Obesity and endocrine disorders in women taking valproate for epilepsy. Ann Neurol 39:579–584

    Article  PubMed  CAS  Google Scholar 

  18. Isojarvi JI, Tauboll E, Pakarinen AJ, van Parys J, Rattya J, Harbo HF, Dale PO, Fauser BC, Gjerstad L, Koivunen R, Knip M, Tapanainen JS (2001) Altered ovarian function and cardiovascular risk factors in valproate-treated women. Am J Med 111:290–296

    Article  PubMed  CAS  Google Scholar 

  19. Jensen P, Jensen SB, Sorensen PS et al (1990) Sexual dysfunction in male and female patients with epilepsy: a study of 86 outpatients. Arch Sex Behav 19:1–14

    Article  PubMed  CAS  Google Scholar 

  20. Klein P, Serje A, Pezzullo JC (2001) Premature ovarian failure in women with epilepsy. Epilepsia 42:1584–1589

    Article  PubMed  CAS  Google Scholar 

  21. Klein P, van Passel-Clark LM, Pezzullo JC (2003) Onset of epilepsy at the time of menarche. Neurology 60:495– 497

    PubMed  Google Scholar 

  22. May TW, Pfaefflin M, Coban I, Schmitz B (2005) Frauen mit Epilepsie brauchen Beratung – Ergebnisse aus der Studie „Frauen mit Epilepsie“ Zeitschrift für Epileptologie 18:113 (Abstract)

    Google Scholar 

  23. McAuley JW, Koshy SJ, Moore JL, Peebles CT, Reeves AL (2000) Characterization and health risk assessment of postmenopausal women with epilepsy. Epilepsy Behav 1:353–355

    Article  PubMed  Google Scholar 

  24. Meo R, Bilo L (2003) Polycystic ovary syndrome and epilepsy: a review of the evidence. Drugs 63:1185–1227

    Article  PubMed  Google Scholar 

  25. Morrell MJ, Flynn KL, Done S, Flaster E, Kalayjian L, Pack AM (2005) Sexual dysfunction, sex steroid hormone abnormalities, and depression in women with epilepsy treated with antiepileptic drugs. Epilepsy Behav 6:360–365

    Article  PubMed  Google Scholar 

  26. Morrell MJ, Sperling MR, Stecker M, Dichter MA (1994) Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology 44:243–247

    PubMed  CAS  Google Scholar 

  27. Quigg M, Kiely JM, Shneker B, Veldhuis JD, Bertram EH (2002) 3rd. Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol 51:559–566

    Article  PubMed  Google Scholar 

  28. Rasgon NL, Altshuler LL, Fairbanks L, Elman S, Bitran J, Labarca R, Saad M, Kupka R, Nolen WA, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Leverich G, Grunze H, Walden J, Post R, Mintz J (2005) Reproductive function and risk for PCOS in women treated for bipolar disorder. Bipolar Disord 7:246–259

    Article  PubMed  Google Scholar 

  29. Schmidt D, Canger R, Avanzini G, Battino D, Cusi C, Beck-Mannagetta G, Koch S, Rating D, Janz D (1983) Change of seizure frequency in pregnant epileptic women. J Neurol Neurosurg Psychiatry 46:751–755

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bettina Schmitz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schmitz, B. Antiepileptika und Hormone bei Frauen. Z. Epileptol. 19, 199–203 (2006). https://doi.org/10.1007/s10309-006-0212-2

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10309-006-0212-2

Key words

Schlüsselwörter

Navigation