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Wachstumshormon und Antiepileptika

Human growth hormone and antiepileptic drugs

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Abstract

Secretion of human growth hormone (hGH) is not influenced by antiepileptic drugs either in children or in adults. Investigated are phenobarbital, valproid acid, carbamazepine and phenytoin in mono- and polytherapy. This is in accordance with the achievement of normal adult height of children treated with antiepileptic drugs for epileptic seizures.

Zusammenfassung

Die Sekretion des Wachstumshormes (hGH) wird durch die Gabe von Antiepileptika weder im Kindes- noch im Erwachsenenalter negativ beeinflusst. Untersucht sind die Antiepileptika Phenobarbital, Valproat, Carbamazepin und Phenytoin in Monotherapie. Auch Kombinationstherapien unterschiedlicher Zusammensetzung üben keine negativen Effekte auf die hGH-Freisetzung auf. Das Erreichen einer normalen Körpergröße unter antikonvulsiver Behandlung bestätigen diese Befunde.

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Authors and Affiliations

  1. Universitätskinderklinik Münster, Bereich Neuropädiatrie, Albert-Schweitzer-Straße 33, 48129, Münster, Germany

    Gerhard Kurlemann

  2. Universitätskinderklinik Münster, Bereich Neuropädiatrie, Albert-Schweitzer-Straße 33, 48129, Münster, Germany

    Bärbel Fiedler

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  1. Gerhard Kurlemann
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  2. Bärbel Fiedler
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Correspondence to Gerhard Kurlemann.

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Kurlemann, G., Fiedler, B. Wachstumshormon und Antiepileptika. Z. Epileptol. 19, 187–190 (2006). https://doi.org/10.1007/s10309-006-0210-4

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  • DOI: https://doi.org/10.1007/s10309-006-0210-4

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