Skip to main content
SpringerLink
Log in

Besondere Bedeutung von Knochenstoffwechselstörungen bei mehrfach–behinderten Menschen mit Epilepsie

Special meaning of metabolic bone disorder for multiply handicapped persons with epilepsy

  • BEITRAG ZUM THEMENSCHWERPUNKT
  • Published:
Zeitschrift für Epileptologie Aims and scope Submit manuscript

Abstract

Mentally and physically handicapped patients with epilepsy may have an increased risk of osteoporosis due to different reasons: alimentary problems, lack of sport, chronic medication, especially antiepileptic drugs. Patients with special syndromes have an elevated risk for osteoporosis, especially people with Down syndrome. Other reasons may play a role: comorbidity, lack of sunlight exposure, lack of information about osteoporosis.

Zusammenfassung

Mehrfachbehinderte Menschen mit Epilepsie haben möglicherweise ein erhöhtes Osteoporoserisiko aufgrund von Ernährungsmängel mit Unter– oder Übergewicht, Bewegungsmangel, chronischer Medikation, insbesondere Antiepileptika. Patienten mit speziellen Syndromen, insbesondere Down–Syndrom haben ein höheres Risiko bei der Entwicklung einer Osteoporose. Weiterhin sind Begleiterkrankungen, geringe Sonnenlichtexposition und mangelnde Informiertheit (von Patienten und Betreuer) möglicherweise wichtige Gründe für die erhöhte Inzidenz von Osteoporose in dieser Patientengruppe.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allgemeine Empfehlungen der deutschen Gesellschaft für Osteologie zur Prophylaxe der Osteoporose: http://www. uni–duesseldorf.de/ WWW/AWMF/ll/034–002. htm

  2. Berry JL, Mawer EB, Walker DA (1983) Effect of antiepileptic drug therapy and exposure to sunlight on Vitamin D status in institutionalized patients. In: Oxley J, Janz D, Meinardi H (eds) Antiepileptic therapy: chronic toxicity of antiepileptic drugs. Raven Press, New York, pp 185–192

  3. Boluk A, Guzelipek M, Savli H, Temel I, Ozisik HI, Kaygusuz A (2004) The effect of valproate on bone mineral density in adult epileptic patients. Pharmacol Res 50:93–97

    Article  PubMed  Google Scholar 

  4. Churesigaew S, Ruvalcaba RH, Kelley VC (1975) Epilepsy and abnormal calcium metabolism in institutionalized mentally retarded patients. Am J Ment Defic 79:738–741

    PubMed  Google Scholar 

  5. Desai KB, Ribbans WJ, Taylor GJ (1996) Incidence of five common fracture types in an institutional epileptic population. Injury 27:97–100

    Article  PubMed  Google Scholar 

  6. DNA direkt. http://www. dna–direkt.de/botframe_files/osteoporose.htm

  7. Drezner MK (2004) Treatment of anticonvulsant drug–induced bone disease. Epilepsy Behav 5(Suppl 2):S41– 47

    Article  PubMed  Google Scholar 

  8. Farhat G, Yamout B, Mikati MA, Demirjian S, Sawaya R, El–Hajj Fuleihan G (2002) Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology (14)58:1348–1353

    PubMed  Google Scholar 

  9. Fitzpatrick LA (2004) Pathophysiology of bone loss in patients receiving anticonvulsant therapy. Epilepsy Behav (Suppl 2):S3–15

    Article  Google Scholar 

  10. Leitlinien des Qualitätszirkel norddeutschen AG ärztliche Dienste für Menschen mit geistiger Behinderung (2000)

  11. Lidgren L, Walloe A (1997) Incidence of fractures in epileptics. Acta Orthop Scand 48:356–361

    Google Scholar 

  12. Lloyd ME, Spector TD, Howard R (2000) Osteoporosis in neurological disorders. J Neurol Neurosurg Psychiatry 68:543–547

    Article  PubMed  Google Scholar 

  13. Lohiya GS, Crinella FM, Tan–Figueroa L, Caires S, Lohiya S (1999) Fracture epidemiology and control in a developmental center. West J Med 170(4):203– 209

    PubMed  Google Scholar 

  14. Lohiya GS, Tan–Figueroa L, Iannucci A (2004) J Identification of low bone mass in a developmental center: finger bone mineral density measurement in 562 residents. Am Med Dir Assoc 5(6):371–376

    Google Scholar 

  15. Lohiya GS, Lohiya S, Tan–Figueroa L (1999) Eighteen fractures in a man with profound mental retardation. Ment Retard 37(1):47–51

    Article  PubMed  Google Scholar 

  16. Mattson RH, Gidal BE (2004) Fractures, epilepsy, and antiepileptic drugs. Epilepsy Behav 5(Suppl 2):S36–40

    PubMed  Google Scholar 

  17. Mugica I, Ansa J, Sistiaga F, Zabalza R, Zubillaga P, Merino A, Mojedano B, Vidal C (2002) Digital computerized absorptiometry in the diagnosis of osteoporosis in a group of the severely mentally retarded. Nutr Hosp 17(4):213–218

    PubMed  Google Scholar 

  18. Pack AM, Morrell MJ (2004) Epilepsy and bone health in adults. Epilepsy Behav 5(Suppl 2):S24–29

    PubMed  Google Scholar 

  19. Sato Y, Kondo I, Ishida S, Motooka H, Takayama K, Tomita Y, Maeda H, Satoh K (2001) Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology 14;57(3):445–449

    Google Scholar 

  20. Shath RD, Wesolowski CA, Jacob JC, Penney S, Hobbs GR, Riggs JE, Bodensteiner JB (1995) Effect of carbamazepine and valproate on bone mineral density. J Pediatr 127(2):256– 262

    PubMed  Google Scholar 

  21. Sheth RD (2002) Bone health in epilepsy. Epilepsia 43(12):1453–1454

    Article  PubMed  Google Scholar 

  22. Stephen LJ, McLellan AR, Harrsion JH, Shapiro D, Dominiczak MH, Sills GJ, Brodie MJ (1999) Bone density and antiepileptic drugs: a case–controlled study. Seizure 8(6):339–342

    Article  PubMed  Google Scholar 

  23. Thorbecke R (2003) Sport bei Epilepsie. In: Wolf P (ed) (Hrsg) Praxisbuch Epilepsie, Kohlhammer Verlag, S 313– 318

  24. Van Allen MI, Fung J, Jurenka SB (1999) Health care concerns and guidelines for adults with Down syndrome. Am J Med Genet 25;89(2):100–110

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sächsisches Epilepsiezentrum, Radeberg–Kleinwachau, Wachauerstr. 30, 01454, Radeberg, Germany

    Thomas Mayer

Authors
  1. Thomas Mayer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Mayer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mayer, T. Besondere Bedeutung von Knochenstoffwechselstörungen bei mehrfach–behinderten Menschen mit Epilepsie. Z. Epileptol. 18, 178–183 (2005). https://doi.org/10.1007/s10309-005-0144-2

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10309-005-0144-2

Key words

Schlüsselwörter

Search

Navigation