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Gibt es optimale Serumprogesteronwerte in In-vitro-Fertilisations- und Kryozyklen?

Can optimal serum levels of progesterone in in vitro fertilization and frozen embryo transfer cycles be defined?

Gynäkologische Endokrinologie volume 19, pages 118–123 (2021)Cite this article

Zusammenfassung

Progesteron ist essenziell für die Bereitstellung eines rezeptiven Endometriums und für die Aufrechterhaltung einer Frühschwangerschaft. Während Progesteron bei einer Konzeption im Spontanzyklus vom Corpus luteum produziert wird, ist die Lutealphase nach hormoneller Stimulation zur Vorbereitung auf die In-vitro-Fertilisation oder intrazytoplasmatische Spermieninjektion von einer unterschiedlich stark ausgeprägten Lutealphaseninsuffizienz gekennzeichnet. Die Notwendigkeit einer Lutealphasensubstitution ist unumstritten und die Wahl derselben muss an die vorausgegangene Therapie angepasst werden. „Minimale“ und „optimale“ Progesteronwerte zum Erreichen und Erhalt einer Schwangerschaft sind weder für Transferzyklen mit frischen Embryonen noch für Transferzyklen mit kryokonservierten Embryonen eindeutig definiert.

Abstract

Progesterone is essential for endometrial receptivity, implantation and the maintenance of an early pregnancy. In spontaneous conception cycles, progesterone is produced by the corpus luteum; however, after hormonal stimulation for preparation for in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) the luteal phase is characterized by a variably severe luteal phase insufficiency. The necessity for a luteal phase support is indisputable and has to be selected according to the preceding treatment. So far, “minimal” and “optimal” ranges of progesterone levels to achieve and maintain a pregnancy are not clearly defined, neither for transfer cycles with fresh embryos nor for transfer cycles with frozen embryos.

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Authors and Affiliations

  1. ART Fertility Clinics LLC, Villa No. B22–23, Marina Village, Behind Marina Mall, P.O. Box – 60202, Abu Dhabi, Vereinigte Arabische Emirate

    B. Lawrenz &  H. M. Fatemi

  2. Universitäts-Frauenklinik Tübingen, Tübingen, Deutschland

    B. Lawrenz

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  1. B. Lawrenz
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  2. H. M. Fatemi
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Correspondence to B. Lawrenz.

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Interessenkonflikt

B. Lawrenz und H.M. Fatemi geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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G. Griesinger, Lübeck

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Lawrenz, B., Fatemi, H.M. Gibt es optimale Serumprogesteronwerte in In-vitro-Fertilisations- und Kryozyklen?. Gynäkologische Endokrinologie 19, 118–123 (2021). https://doi.org/10.1007/s10304-020-00366-3

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Schlüsselwörter

  • Hormonelle Stimulation
  • IVF/ICSI
  • Lutealphase
  • Transfer frischer Embryonen
  • Verfahren der assistierten Reproduktion/Outcome

Keywords

  • Hormonal stimulation
  • IVF/ICSI
  • Luteal phase
  • Embryo transfer, fresh
  • Reproductive techniques, assisted/outcome