Literatur
Rai R, Regan L (2006) Recurrent miscarriage. Lancet 368:601–611. https://doi.org/10.1016/S0140-6736(06)69204-0
van Dijk MM, Kolte AM, Limpens J et al (2020) Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis. Hum Reprod Update 26:356–367. https://doi.org/10.1093/humupd/dmz048
The ESHRE Guideline Group on RPL, Bender Atik R, Christiansen OB et al (2018) ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open 2018:1337–1313. https://doi.org/10.1093/hropen/hoy004
Nielsen S, Hahlin M (1994) Expectant management of first-trimester sponteous abortion. Lancet 345:84–86
Wu H‑L, Marwah S, Wang P et al (2017) Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis. Sci Rep. https://doi.org/10.1038/s41598-017-01892-0
Jurkovic D, Ross JA, Nicolaides KH (1998) Expectant management of missed miscarriage. Br J Obstet Gynaecol 105:670–671. https://doi.org/10.1111/j.1471-0528.1998.tb10184.x
Sliwa J, Kryza-Ottou A, Rosner-Tenerowicz A et al (2019) Comparison of the diagnostic value of histopathological examinations of miscarriage products after pharmacological induction of miscarriage and curettage. Ginekol Pol 90:331–335. https://doi.org/10.5603/GP.2019.0061
Vyas NA, Vink JS, Ghidini A et al (2006) Risk factors for cervical insufficiency after term delivery. Am J Obstet Gynecol 195:787–791. https://doi.org/10.1016/j.ajog.2006.06.069
McCarthy FP, Khashan AS, North RA et al (2013) Pregnancy loss managed by cervical dilatation and curettage increases the risk of spontaneous preterm birth. Hum Reprod 28:3197–3206. https://doi.org/10.1093/humrep/det332
Hooker AB, Lemmers M, Thurkow AL et al (2014) Systematic review and meta-analysis of intrauterine adhesions after miscarriage: prevalence, risk factors and long-term reproductive outcome. Hum Reprod Update 20:262–278. https://doi.org/10.1093/humupd/dmt045
Hooker AB, de Leeuw RA, van de Ven PM et al (2018) Reproductive performance after the application of hyaluronic acid gel after dilation and curettage in women who have experienced at least one previous curettage: long-term results of a multicenter prospective randomized trial. Fertil Steril 110:1231–1238. https://doi.org/10.1016/j.fertnstert.2018.07.021
Hooker AB, de Leeuw R, van de Ven PM et al (2017) Prevalence of intrauterine adhesions after the application of hyaluronic acid gel after dilatation and curettage in women with at least one previous curettage: short-term outcomes of a multicenter, prospective randomized controlled trial. Fertil Steril 107:1223–1231.e3. https://doi.org/10.1016/j.fertnstert.2017.02.113
Berg J, Hamel CC, Snijders MP et al (2019) Mifepristone and misoprostol versus misoprostol alone for uterine evacuation after early pregnancy failure: study protocol for a randomized double blinded placebo-controlled comparison (Triple M Trial). 19(1):443. https://doi.org/10.1186/s12884-019-2497-y
WHO (Hrsg) (2018) Medical management of abortion. World Health Organization, Geneva (Licence: CC BY-NC-SA 3.0 IGO.)
Gemzell-Danielsson K, Ho PC, Gómez Ponce de León R et al (2007) Misoprostol to treat missed abortion in the first trimester. Int J Gynaecol Obstet 99:S182–S185. https://doi.org/10.1016/j.ijgo.2007.09.008
Tang OS, Schweer H, Seyberth HW et al (2002) Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod 17:332–336. https://doi.org/10.1093/humrep/17.2.332
National Guideline Alliance (UK) (2019) Ectopic pregnancy and miscarriage: diagnosis and initial management. National Institute for Health and Care Excellence, London ((NICE Guideline, No. 126.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK544906/)
Colleselli V, Nell T, Bartosik T et al (2016) Marked improvement in the success rate of medical management of early pregnancy failure following the implementation of a novel institutional protocol and treatment guidelines: a follow-up study. Arch Gynecol Obstet 294:1265–1272. https://doi.org/10.1007/s00404-016-4179-6
Schreiber CA, Creinin MD, Atrio J et al (2018) Mifepristone pretreatment for the medical management of early pregnancy loss. N Engl J Med 378:2161–2170. https://doi.org/10.1056/NEJMoa1715726
Colleselli V, Schreiber CA, D’Costa E et al (2013) Medical management of early pregnancy failure (EPF): a retrospective analysis of a combined protocol of mifepristone and misoprostol used in clinical practice. Arch Gynecol Obstet 289:1341–1345. https://doi.org/10.1007/s00404-013-3105-4
(2020) Abstracts 36th Virtual Annual Meeting of the European Society of Human Reproduction and Embryology. Human Reproduction 1–522. https://doi.org/10.1093/humrep/35.Supplement_1.1
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H. Kentenich, Berlin
W. Küpker, Baden-Baden
S. Tschudin, Basel
L. Wildt, Innsbruck
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Freis, A. Therapie der „missed abortion“ – wo stehen wir?. Gynäkologische Endokrinologie 19, 73–75 (2021). https://doi.org/10.1007/s10304-020-00354-7
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DOI: https://doi.org/10.1007/s10304-020-00354-7