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Thrombophilieabklärung im Hinblick auf östrogenhaltige Kontrazeptiva und Hormonersatztherapie

Thrombophilia, combined oral contraceptives and hormone replacement

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Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Östrogenhaltige Kontrazeptiva und eine Hormonersatztherapie werden weltweit von Millionen Frauen genutzt. Obwohl die Verträglichkeit generell sehr gut ist, besteht ein Risiko venöser und arterieller Thromboembolien. Im vorliegenden Beitrag werden nicht nur häufige Thrombophilien beschrieben, sondern Risikofaktoren für Thrombosen und Lungenembolien erklärt. Das thromboembolische Risiko unter verschiedenen Präparaten wird diskutiert und Risikofaktoren unter einer entsprechenden Therapie beschrieben. Zudem werden Handlungsanweisungen für die tägliche Praxis präsentiert.

Abstract

Combined oral contraceptives (COC) and hormone replacement treatment are used by millions of women worldwide due to the reliable contraception and other health benefits they offer. Although side effects are few, the treatment puts patients at risk for venous and atrial thromboembolism. The following article describes common thrombophilic situations and risk factors for deep vein thrombosis and pulmonary embolism. The thromboembolic risk of patients treated with different types of estrogen-containing drugs is summarized and related risk factors discussed. Guidance for use in clinical practice is also provided.

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Authors and Affiliations

  1. Universitätsklinik für Hämatologie und Hämatologisches Zentrallabor, Inselspital Universitätsspital, Bern, Schweiz

    M. Pollak

  2. Universitäres Institut für Klinische Chemie, Inselspital Universitätsspital und Universität Bern, Freiburgerstrasse, 3010, Bern, Schweiz

    M. Nagler

  3. Universität Bern, Bern, Schweiz

    M. Nagler

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  1. M. Pollak
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Correspondence to M. Nagler.

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Interessenkonflikt

M. Pollak und M. Nagler geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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B. Imthurn, Zürich

B. Toth, Innsbruck

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Pollak, M., Nagler, M. Thrombophilieabklärung im Hinblick auf östrogenhaltige Kontrazeptiva und Hormonersatztherapie. Gynäkologische Endokrinologie 17, 139–147 (2019). https://doi.org/10.1007/s10304-019-0262-y

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  • DOI: https://doi.org/10.1007/s10304-019-0262-y

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