Skip to main content
SpringerLink
Log in

Intrauterine Insemination

Intrauterine insemination

  • CME Weiterbildung · Zertifizierte Fortbildung
  • Published:
Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Eine der am weitesten verbreiteten Techniken im Rahmen der Reproduktionsmedizin ist die intrauterine Insemination (IUI); sie ist neben der extrakorporalen Befruchtung (In-vitro-Fertilisation/intrazytoplasmatische Spermieninjektion) weiterhin eine wichtige Therapieoption für ungewollt kinderlose Paare.

Die Verfahren der IUI wurden in den letzten Jahren deutlich verbessert: Die Techniken der Spermienaufbereitung wurden modifiziert, das Zyklusmonitoring kann durch die Ovulationsinduktion, etwa mit humanem Choriongonadotropin, gezielt und damit besser terminiert werden. Zudem wurden verschiedene Medikamente für die Stimulation entwickelt, z. B. Clomifencitrat und Gonadotropine.

Abstract

Intrauterine insemination (IUI) is one of the most commonly used techniques in reproductive medicine and together with extracorporeal fertilization, e.g. in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is the most important therapy option for couples with undesired childlessness. The methods of IUI have been improved in recent years, the techniques of sperm purification have been modified, the monitoring of cycles optimized through induction of ovulation, e.g. ovulation induction with human chorionic gonadotropin (hCG) and new pharmaceutical products for stimulation have been developed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3
Abb. 4

Literatur

  1. Crosignani PG (2009) Intrauterine insemination. ESHRE Capri Workshop Group. Hum Reprod Update 15:265–277

    Article  Google Scholar 

  2. Bensdorp AJ, Cohlen BJ, Heineman MJ et al (2007) Intra-uterine insemination for male subfertility. Cochrane Database Syst Rev 3:CD000360

    PubMed  Google Scholar 

  3. Merviel P, Heraud MH, Grenier N et al (2010) Predictive factors for pregnancy after intrauterine insemination (IUI): an analysis of 1038 cycles and a review of the literature. Fertil Steril 93:79–88

    Article  PubMed  Google Scholar 

  4. Marshburn PB, Alanis M, Matthews ML et al (2009) A short period of ejaculatory abstinence before intrauterine insemination is associated with higher pregnancy rates. Fertil Steril 93:286–288

    Article  PubMed  Google Scholar 

  5. Verhulst SM, Cohlen BJ, Hughes E et al (2006) Intra-uterine insemination for unexplained subfertility. Cochrane Database Syst Rev 4:CD001838

    PubMed  Google Scholar 

  6. Wordsworth S, Buchanan J, Mollison J et al (2011) Clomifene citrate and intrauterine insemination as first-line treatments for unexplained infertility: are they cost-effective? Hum Reprod 26:369–375

    Article  PubMed  CAS  Google Scholar 

  7. Helmerhorst FM, Van Vliet HA, Gornas T et al (2005) Intra-uterine insemination versus timed intercourse for cervical hostility in subfertile couples. Cochrane Database Syst Rev 4:CD002809

    PubMed  Google Scholar 

  8. Nawroth F, Dorn C, Ludwig M (2010) Die intrauterine Insemination. Indikationen und Grenzen. In: Gynäkologische Endokrinologie und Reproduktionsmedizin. Hans Marseille Verlag GmbH, München

  9. Greb R (2004) Ovarielle Stimulation und intrauterine Insemination (COH-IUI). Gynäkologische Endokrinologie 4:194–99

    Article  Google Scholar 

  10. Kupka MS, Franz M, Friese K (2007) Hepatitis, HIV und Kinderwunsch. Gynäkologe 10:780–789

    Article  Google Scholar 

  11. Bujan L, Hollander L, Coudert M et al (2007) Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected: results from the European CREAThE network. AIDS 21:1909–1914

    Article  PubMed  Google Scholar 

  12. Katzorke T (2007) Donogene Insemination. Gynäkologe 10:807–812

    Article  Google Scholar 

  13. Thorn P (2010) Geplante lesbische Familien. Gynäkologische Endokrinologie 8:73–81

    Article  Google Scholar 

  14. Wischmann T (2008) Psychosoziale Aspekte der Spendersamenbehandlung – eine Übersicht. Geburtsh Frauenheilkunde 68:1147–1153

    Article  Google Scholar 

  15. Montzka P (1998) Grundlagen der Inseminationsbehandlung. In: Diedrich K (Hrsg) Weibliche Sterilität. Springer, Berlin Heidelberg

  16. Kosmas IP, Tatsioni A, Fatemi HM et al (2007) Human chorionic gonadotropin administration vs. luteinizing monitoring for intrauterine insemination timing, after administration of clomiphene citrate: a meta-analysis. Fertil Steril 87:607–612

    Article  PubMed  CAS  Google Scholar 

  17. Claman P, Wilkie V, Collins D (2004) Timing intrauterine insemination either 33 or 39 hours after administration of human chorionic gonadotropin yields the same pregnancy rates as after superovulation therapy. Fertil Steril 82:13–16

    Article  PubMed  CAS  Google Scholar 

  18. Tanahatoe SJ, Lambalk CB, Hompes PG (2005) The role of laparoscopy in intrauterine insemination: a prospective randomized reallocation study. Hum Reprod 20:3225–3230

    Article  PubMed  CAS  Google Scholar 

  19. Tanahatoe S, Lambalk C, McDonnell J et al (2008) Diagnostic laparoscopy is needed after abnormal hysterosalpingography to prevent over-treatment with IVF. Reprod Biomed Online 16:410–415

    Article  PubMed  Google Scholar 

  20. Cantineau AE, Cohlen BJ, Heineman MJ (2007) Ovarian stimulation protocols (anti-oestrogens, gonadotrophins with and without GnRH agonists/antagonists) for intrauterine insemination (IUI) in women with subfertility. Cochrane Database Syst Rev 2:CD005356

    PubMed  Google Scholar 

  21. Dankert T, Kremer JA, Cohlen BJ et al (2007) A randomized clinical trial of clomiphene citrate versus low dose recombinant FSH for ovarian hyperstimulation in intrauterine insemination cycles for unexplained and male subfertility. Hum Reprod 22:792–797

    Article  PubMed  CAS  Google Scholar 

  22. Dickey RP, Taylor SN, Lu PY et al (2004) Clomiphene citrate intrauterine insemination (IUI) before gonadotropin IUI affects the pregnancy rate and the rate of high-order multiple pregnancies. Fertil Steril 81:545–550

    Article  PubMed  CAS  Google Scholar 

  23. Van Rumste MME, Custers IM, Veen F van der et al (2008) The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis. Hum Reprod Update 14:563–570

    Article  Google Scholar 

  24. Reindollar RH, Regan MM, Neumann PJ et al (2010) A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial. Fertil Steril 94:888–899

    Article  PubMed  Google Scholar 

  25. Aboulghar M, Mansour R, Serour G et al (2000) Controlled ovarian hyperstimulation and intrauterine insemination for treatment of unexplained infertility should be limited to a maximum of three trials. Fertil Steril 75:88–91

    Article  Google Scholar 

  26. Dickey RP, Taylor SN, Lu PY et al (2002) Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate-intrauterine insemination. Fertil Steril 78:1088–1095

    Article  PubMed  Google Scholar 

  27. Erdem A, Erdem M, Atmaca S et al (2008) Impact of luteal phase support on pregnancy rates in intrauterine insemination cycles: a prospective randomized study. Fertil Steril 91:2508–2513

    Article  PubMed  Google Scholar 

  28. Sutcliffe AG, Ludwig M (2007) Outcome of assisted reproduction. Lancet 370(9584):351–359

    Article  PubMed  Google Scholar 

  29. Khalil MR, Rasmussen PE, Erb K et al (2001) Homologous intrauterine insemination. An evaluation of prognostic factors based on a review of 2473 cycles. Acta Obstet Gynecol Scand 80:74–81

    Article  PubMed  CAS  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Zentrum für Endokrinologie – Kinderwunsch – Pränatale Medizin im Barkhof, amedes, Mönckebergstr. 10, 20095, Hamburg, Deutschland

    C. Dorn

Authors
  1. C. Dorn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. Dorn.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dorn, C. Intrauterine Insemination. Gynäkologische Endokrinologie 10, 121–131 (2012). https://doi.org/10.1007/s10304-012-0471-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10304-012-0471-0

Schlüsselwörter

Keywords

Search

Navigation