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Physiologische Veränderungen der Schilddrüsenfunktion in der Schwangerschaft

Physiological alterations of thyroid gland function in pregnancy

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Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Die Schilddrüsenfunktion unterliegt während einer Schwangerschaft spezifischen Änderungen, die besonders im 1. Trimenon ausgeprägt sind. Verschiedene Adaptationsmechanismen sichern nicht nur den erhöhten maternalen Bedarf an Schilddrüsenhormonen, sondern stellen auch die Hormone für den fetalen Stoffwechsel bereit, da dieser erst ab der ca. 16. SSW ausreichend eigene Schilddrüsenhormone produziert. Aufgrund dieser Stoffwechseländerungen sollten schwangerschaftsspezifische Referenzintervalle für Schilddrüsenwerte genutzt werden, um Fehlinterpretationen zu vermeiden.

Abstract

Maternal thyroid gland function alters especially in the first trimester. There are various mechanisms ensuring the increased maternal demand for thyroid hormones as well as a sufficient supply for the fetus. Up to the 16th week of gestation the fetal thyroid gland does not sufficiently produce thyroid hormones. As pregnancy reference intervals are to some extent significantly different to non-pregnancy levels, it is advisable to use trimester-specific reference ranges in order to avoid false interpretation.

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Authors and Affiliations

  1. Klinik Für Gynäkologie und Geburtshilfe, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland

    A. Dawson & A. Schroer

  2. Endokrinologikum Hannover, Hannover, Deutschland

    R. Hehrmann

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  1. A. Dawson
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  2. A. Schroer
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  3. R. Hehrmann
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Correspondence to A. Dawson.

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Dawson, A., Schroer, A. & Hehrmann, R. Physiologische Veränderungen der Schilddrüsenfunktion in der Schwangerschaft. Gynäkologische Endokrinologie 7, 219–223 (2009). https://doi.org/10.1007/s10304-009-0305-x

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