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Extrakte aus Mönchspfeffer (Vitex Agnus castus)

Stellenwert der Therapie in der gynäkologischen Praxis

The use of chasteberry extract (vitex agnus castus) in gynecology

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Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Extrakte aus Vitex Agnus castus enthalten dopaminerge Verbindungen, die chemisch zu den Diterpenen gehören. Sie besitzen leichte D2-Rezeptor-agonistische Eigenschaften, die eine latente überschießende Prolaktinsekretion inhibieren können. Eine latente Hyperprolaktinämie kann die Ursache für eine prämenstruelle Mastodynie und für eine Corpus-luteum-Insuffizienz sein. Ähnliche Ergebnisse wurden mit synthetischen dopaminergen Medikamenten erzielt, die allerdings schwerwiegende Nebenwirkungen haben. Unter der Behandlung mit Extrakten aus Vitex Agnus castus dagegen wurden keinerlei unerwünschte Wirkungen beobachtet.

Abstract

Vitex agnus castus extracts contain dopaminergic compounds which, chemically speaking, belong to the diterpenes. They have mild D2 receptor agonistic properties that are able to inhibit latent hyperprolactinemia. Latent hyperprolactinemia may be the cause of premenstrual mastodynia and corpus luteum defects. Similar results were obtained with synthetic dopaminergic drugs; however, these drugs have severe side effects, whereas no adverse effects were observed under treatment with vitex agnus castus extracts.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung hin: Prof. Dr. W. Wuttke ist als Berater für die Firma Bionorica tätig.

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Authors and Affiliations

  1. Department für Endokrinologie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Deutschland

    W. Wuttke, H. Jarry & D. Seidlová-Wuttke

  2. Department of Oncology, Volgograd State Medical University, Volgograd, Russland

    T. Devyatchenko

  3. Department of ObGy, Petrozavodsk State University, Petrozavodsk, Russland

    O. Pogodin

  4. Academy of Medical Sciences Khakov, Khakov, Russland

    S.A. Levenets

Authors
  1. W. Wuttke
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  2. H. Jarry
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  3. D. Seidlová-Wuttke
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  4. T. Devyatchenko
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  5. O. Pogodin
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  6. S.A. Levenets
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Correspondence to W. Wuttke.

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Wuttke, W., Jarry, H., Seidlová-Wuttke, D. et al. Extrakte aus Mönchspfeffer (Vitex Agnus castus). Gynäkologische Endokrinologie 6, 82–86 (2008). https://doi.org/10.1007/s10304-008-0262-9

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  • DOI: https://doi.org/10.1007/s10304-008-0262-9

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