Skip to main content

Vitamin B6 bei prämenstruellem Syndrom

Pyridoxine and PMS

Gynäkologische Endokrinologie volume 6, pages 87–93 (2008)Cite this article

Zusammenfassung

Das prämenstruelle Syndrom (PMS) tritt häufig bei jungen Frauen im gebärfähigen Alter auf, es kann aber auch erst zu Beginn der Perimenopause manifest werden. Etwa 5% der Patientinnen leiden unter einer schweren Form, der prämenstruellen dysphorischen Störung (PMDS). Aufgrund einer fehlenden einheitlichen pathophysiologischen Genese erfolgt die Behandlung symptomatisch in Form eines multikausalen Stufentherapiekonzeptes nach eingehender Diagnostik und Ausschluss anderer Erkrankungen. Neben einer Vielzahl an sowohl pharmakologischen als auch nichtmedikamentösen Strategien ist die Gabe von Vitamin B6 eine mögliche Option zur Linderung insbesondere der psychischen Beschwerden, die für die betroffenen Frauen oftmals eine größere Beeinträchtigung darstellen können als die körperlichen Symptome. Der vorliegende Beitrag erläutert die klinische Wirksamkeit von Vitamin B6 bei PMS aufgrund der aktuellen wissenschaftlichen Literatur.

Abstract

Premenstrual syndrome is common in young women but can also arise at the beginning of the perimenopausal phase. Approximately 5% of patients suffer from premenstrual dysphoric disorder (PMDD), a severe form of PMS. Due to the lack of a consistent pathophysiological etiology, treatment is symptomatic in terms of a multi-causal, stepwise treatment concept after exact diagnosis and exclusion of other diseases. In addition to a range of both pharmacological and non-pharmacological strategies, the administration of vitamin B6 is a potential option, particularly for alleviating psychic disorders, which often cause patients greater problems than physical disorders. This article highlights the clinical efficacy of vitamin B6 for premenstrual disorder on the basis of the current scientific literature.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Literatur

  1. Bendich A (2000) The Potential for Dietary Supplements to Reduce Premenstrual Syndrome (PMS) Symptoms. J Am College Nutrition 19: 3–12

    CAS  Google Scholar 

  2. De Souza MC, Walker AF, Robinson PA, Bolland K (2000) A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Women Health Gender Based Med 9: 131–139

    Article  Google Scholar 

  3. Dimmock PW, Wyatt KM, Jones PW, O’Brien PM (2000) Efficacy of selective serotonin-reuptake inhibitors in premenstrual syndrome: a systematic review. Lancet 356: 1131–1136

    Article  PubMed  CAS  Google Scholar 

  4. Endicott J, Amsterdam J, Eriksson E et al. (1999) Is premenstrual dysphoric disorder a distinct clinical entity? J Womens Health Gender Based Med 8: 663–679

    CAS  Google Scholar 

  5. Facchinetti F, Genazzani MD, Martignoni E et al. (1990) Neuroendocrine correlate of premenstrual syndrome. Psychoneuroendocrinology 15: 269

    Article  PubMed  CAS  Google Scholar 

  6. Feuerstein M, Shaw WS (2002) Measurement properties of the calendar of premenstrual experience in patients with premenstrual syndrome. J Reprod Med 47: 279–289

    PubMed  Google Scholar 

  7. Fugh-Berman A, Kronenberg F (2003) Complementary and alternative medicine (CAM) in reproductive-age women: a review in randomized controlled trials. Reprod Toxicol 17: 137–152

    Article  PubMed  CAS  Google Scholar 

  8. Fryer CP, Kaspi SP, Fallon SK et al. (1999) Premenstrual dysphoric disorder: literature review. Arch Womens Mental Health 2: 1–27

    Article  Google Scholar 

  9. Girman A, Lee R, Kligler B (2003) An integrative medicine approach to premenstrual syndrome. Am J Obstet Gynecol 188: S56–S65

    Article  PubMed  Google Scholar 

  10. Halbreich U (2003) The etiology, biology, and evolving pathology of premenstrual syndromes. Psychoneuriendocrinology 28: 55–99

    Article  CAS  Google Scholar 

  11. Halbreich U, Endicott J (1981) Possible involvement of endorphine withdrawl or imbalance in specific premenstrual syndromes and postpartum depression. Med Hypotheses 7: 1045

    Article  PubMed  CAS  Google Scholar 

  12. Hvas A-M, Juul S, Bech P, NexØ E (2004) Vitamin B6 level is associated with symptoms of depression. Psychother Psychosom 73: 340–343

    Article  PubMed  Google Scholar 

  13. Janiger O, Riffenburgh R, Kersh R (1972) Cross cultural study of premenstrual symptoms. Psychosomatics 13: 226

    PubMed  CAS  Google Scholar 

  14. Kashanian M, Mazinani R, Jalalmanesh S (2007) Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Int J Gynaecol Obstet 96: 43–44

    Article  PubMed  CAS  Google Scholar 

  15. Kendall KE, Schurr PP (1987) The effects of vitamin B6 supplementation on premenstrual symptoms. Obstet Gynecol 70: 145–149

    PubMed  CAS  Google Scholar 

  16. Lauritzen C, Reuter HD, Repges R et al. (1997) Treatment of premenstrual tension syndrome with Vitex agnus castus controlles, double-blind study versus pyridoxine. Phytomedicine 4: 183–189

    CAS  Google Scholar 

  17. Lenzinger E, Diamant K, Vytiska-Binstorfer E, Kasper S (1997) Prämenstruelle dysphorische Störung (PMDS). Nervenarzt 68: 708–718

    Article  PubMed  CAS  Google Scholar 

  18. London RS, Bradley L, Chiamori NY (1991) Effect of nutritional supplement of premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study. J Am Coll Nutr 10: 494–499

    PubMed  CAS  Google Scholar 

  19. Löffler G (2003) Vitamine. In Löffler G, Petrides P (Hrsg) Biochemie und Pathobiochemie. Springer, Berlin Heidelberg New York, S 741

  20. Mishell DR (2005) Premenstrual disorders: epidemiology and disease burden. Am J Managed Care 11: 473–479

    Google Scholar 

  21. Proctor ML, Murphy PA (2001) Herbal and dietary therapies for primary and secondary dysmenorrhoea. The Cochrane Database of Systematic Review: Issue 2

    Google Scholar 

  22. Rapkin AJ, Edelmuth E, Chang LC et al. (1987) Whole-blood serotonin in premenstrual syndrome. Obstet Gynecol 70: 533–537

    PubMed  CAS  Google Scholar 

  23. Rapkin AJ, Shoupe D, Reading A et al (1996) Decreased central opioid activity in premenstrual syndrome: luteinizing hormone response to naloxone. J Soc Gyn Invest 3: 93–98

    Article  CAS  Google Scholar 

  24. Reid RL, Yen SSC (1981) Premenstrual syndrome. Am J Obstet Gynecol 139: 85–104

    PubMed  CAS  Google Scholar 

  25. Saß Henning (1996) Diagnostisches und statistisches Manual psychischer Störungen. Hogrefe, Göttingen

  26. Seippel L, Bäckström T (1998) Luteal-phase estradiol relates to symptom severity in patients with premenstrual syndrome. Jo Clinical Endocrinol Metabolism 83: 1988–1992

    Article  CAS  Google Scholar 

  27. Steiner M, Macdougall M, Bown E (2003) The premenstrual symptoms screening tool (PSST) for clinicians. Arch Women Ment Health 6: 203–209

    Article  CAS  Google Scholar 

  28. Steward A (1987) Clinical and biochemical effects of nutritional supplementation on the premenstrual syndrome. J Reprod Med 32: 435–441

    Google Scholar 

  29. Tulenheimo A, Laatikanen T, Salminen K (1987) Plasma ß-endorphin immunoreactivity in premenstrual tension. Br J Obstet Gynecol 94: 26

    CAS  Google Scholar 

  30. Villegas-Sala E (1997) Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive. Contraception 55: 245–248

    Article  Google Scholar 

  31. Williams A, Cotter A, Sabina A et al. (2005) The role for vitamin B-6 as treatment for depression: a systematic review. Family Practice 22: 532–537

    Article  PubMed  Google Scholar 

  32. Williams MJ, Harris RI, Dean BC (1985) Controlled trial of pyridoxine in the premenstrual syndrome. J Int Med Res 13: 174–179

    PubMed  CAS  Google Scholar 

  33. Wyatt KM, Dimmock PW, Jones PW, O’Brien PM (1999) Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. Br Medical J 318: 1375–1381

    CAS  Google Scholar 

  34. Wyatt KM, Dimmock PW, Jones PW et al. (2001) Efficacy of progesterone and progestogens in management of premenstrual syndrome: a systematic review. BJM 323: 776–780

    Article  CAS  Google Scholar 

  35. Wyatt KM, Dimmock PW, Ismail KMK et al. (2004) The effectiveness of GnRHa with and without „add-back“ therapy in treating premenstrual syndrome: a meta analysis. Br J Obstet Gynaecol 111: 585–593

    CAS  Google Scholar 

  36. Zahradnik HP, Wetzka B, Schuth W (2000) Zyklusabhängige Befindlichkeitsstörungen der Frau. Gynäkologe 33: 225–238

    Article  Google Scholar 

Download references

Interessenskonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin: Erstellung eines wissenschaftlichen Gutachtens für Biokanol Pharma GmbH, Honorar an Universität Heidelberg.

Author information

Authors and Affiliations

  1. Ambulanz für Naturheilkunde/Integrative Medizin (ANIMed), Abteilung Endokrinologie und Fertilitätsstörungen, Universitätsfrauenklinik Heidelberg, Voßstraße 9, 69115, Heidelberg, Deutschland

    B. Reinhard-Hennch & T. Strowitzki

Authors
  1. B. Reinhard-Hennch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Strowitzki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. Reinhard-Hennch.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Reinhard-Hennch, B., Strowitzki, T. Vitamin B6 bei prämenstruellem Syndrom. Gynäkologische Endokrinologie 6, 87–93 (2008). https://doi.org/10.1007/s10304-008-0260-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10304-008-0260-y

Schlüsselwörter

  • Prämenstruelles Syndrom (PMS)
  • Prämenstruelle dysphorische Störung (PMDS)
  • Depression
  • Vitamin B6
  • Pyridoxin

Keywords

  • Premenstrual syndrome
  • Late luteal phase dysphoric disorder
  • Depression
  • Vitamin B6
  • Pyridoxine