Skip to main content
Log in

Cimicifuga, Johanniskraut und andere Phytotherapeutika im Klimakterium

Cimicifuga, St. John’s wort and other herbal medicines for menopausal syndrome

  • Leitthema
  • Published:
Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Klimakterische Beschwerden sind in der weiblichen Bevölkerung aufgrund der demographischen Entwicklung mittlerweile weit verbreitet. Dementsprechend steigt die Nachfrage nach Therapiemöglichkeiten. Der Beitrag stellt den aktuellen Erkenntnisstand zu den bekanntesten zur Behandlung von Wechseljahresbeschwerden eingesetzten Phytotherapeutika vor.

Abstract

Due to demographic developments, climacteric symptoms are now widespread in the female population. This increases the demand for therapeutic options. The following article presents current knowledge concerning the most common herbal medical preparations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Anderson GL, Limacher M, Assaf AR et al. (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 291: 1701–1712

    Article  PubMed  CAS  Google Scholar 

  2. Bai W, Henneicke-von Zepelin HH, Wang S et al. (2007) Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone. Maturitas 58: 31–41

    Article  PubMed  CAS  Google Scholar 

  3. Bodinet C, Freudenstein J (2004) Influence of marketed herbal menopause preparations on MCF-7 cell proliferation. Menopause 11: 281–289

    Article  PubMed  Google Scholar 

  4. Briese V, Stammwitz U, Friede M, Henneicke-von Zepelin HH (2007) Black cohosh with or without St. John’s wort for symptom-specific climacteric treatment – results of a large-scale, controlled, observational study. Maturitas 57: 405–414

    Article  PubMed  CAS  Google Scholar 

  5. Burdette JE, Liu J, Chen SN et al. (2003) Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem 51: 5661–5670

    Article  PubMed  CAS  Google Scholar 

  6. Carroll DG (2206) Nonhormonal therapies for hot flashes in menopause. Am Fam Physician 73: 457–467

    Google Scholar 

  7. Chung DJ, Kim HY, Park KH et al. (2007) Black cohosh and St. John’s wort (GYNO-Plus) for climacteric symptoms. Yonsei Med J 48: 289–294

    Article  PubMed  Google Scholar 

  8. Cumming GP, Herald J, Moncur R et al. (2007) Women’s attitudes to hormone replacement therapy, alternative therapy and sexual health: a web-based survey. Menopause Int 13: 79–83

    Article  PubMed  Google Scholar 

  9. Geller SE (2006) Contemporary alternatives to plant estrogens for menopause. Maturitas 55 (Suppl 1): S3–S13

    Article  PubMed  CAS  Google Scholar 

  10. Grube B, Walper A, Wheatley D (1999) St. John’s Wort extract: efficacy for menopausal symptoms of psychological origin. Adv Ther 16: 177–186

    PubMed  CAS  Google Scholar 

  11. Heger M, Ventskovskiy BM, Borzenko I et al. (2006) Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause13: 744–759

  12. Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A et al. (2007) A special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause14: 270–283

  13. Keenan NL, Mark S, Fugh-Berman A et al. (2003) Severity of menopausal symptoms and use of both conventional and complementary/alternative therapies. Menopause10: 507–515

  14. Kupfersztain C, Rotem C, Fagot R, Kaplan B (2003) The immediate effect of natural plant extract, Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. A preliminary report. Clin Exp Obstet Gynecol 30: 203–206

    PubMed  CAS  Google Scholar 

  15. Liske E (1998) Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv Ther 15: 45–53

    PubMed  CAS  Google Scholar 

  16. Liske E, Hänggi W, Henneicke von Zepelin HH et al. (2002) Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med 11: 163–174

    Article  PubMed  CAS  Google Scholar 

  17. Newton KM, Reed SD, LaCroix AZ et al. (2006) Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, orplacebo. Ann Intern Med 145: 869–879

    PubMed  Google Scholar 

  18. Oktem M, Eroglu D, Karahan HB et al. (2007) Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial. Adv Ther 24: 448–461

    Article  PubMed  CAS  Google Scholar 

  19. Osmers R, Friede M, Liske E et al. (2005) Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol 105: 1074–1083

    PubMed  Google Scholar 

  20. Rossouw JE, Anderson GL, Prentice RL et al. (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 288: 321–333

    Article  PubMed  CAS  Google Scholar 

  21. Rotem C, Kaplan B (2007) Phyto-female complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol 23: 117–122

    Article  PubMed  Google Scholar 

  22. Uebelhack R, Blohmer JU, Graubaum HJ et al. (2006) Black cohosh and St. John’s wort for climacteric complaints: a randomized trial. Obstet Gynecol 107: 247–255

    PubMed  Google Scholar 

  23. Walji R, Boon H, Guns E et al. (2007) Black cohosh (Cimicifuga racemosa [L.] Nutt.): safety and efficacy for cancer patients. Support Care Cancer15: 913–921

    Article  Google Scholar 

  24. Zhou S, Chan E, Pan SQ et al. (2004) Pharmacokinetic interactions of drugs with St John’s wort. J Psychopharmacol18: 262–276

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K. Kraft.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kraft, K. Cimicifuga, Johanniskraut und andere Phytotherapeutika im Klimakterium. Gynäkologische Endokrinologie 6, 72–75 (2008). https://doi.org/10.1007/s10304-008-0256-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10304-008-0256-7

Schlüsselwörter

Keywords

Navigation