Zusammenfassung
Die technischen Möglichkeiten der Präimplantationsdiagnostik sind in den letzten Jahren deutlich verbessert worden. Vor allem modifizierte PCR-Methoden wie „nested PCR“, Multiplex- und Fluoreszenz-PCR und der Transfer des Nukleus mit anschließender FISH haben die Sicherheit der Diagnostik erhöht. Die PGD befasst sich weltweit mit einer Ausweitung des Indikationsspektrums zu Aneuploidiescreening, Prädispositionsdiagnostik von malignen Erkrankungen und Geschlechtswahl nicht nur aus medizinischen Gründen. Die Diskussion zur PGD ist in Deutschland argumentativ erschöpfend geführt, aber nicht abgeschlossen. Es bleibt offen, ob die Methode eingeführt wird und ob Indikationen, die über die Diagnostik schwerwiegender Erbkrankheiten hinausgehen, Berücksichtigung finden werden.
Abstract
Molecular genetic techniques and their use in preimplantation genetic diagnosis (PGD) have been widely expanded in recent years worldwide. The reliability and accuracy of PGD have been improved by including newer PCR modifications such as nested PCR, multiplex and fluorescence PCR, or FISH techniques after nuclear transfer. International discussion on PGD concentrates on expanding indications for PGD, for example, diagnosis of inherited predisposition for cancer and sexing for several reasons. In Germany, an extensive discussion on the basic introduction of PGD has been conducted in recent years, but not yet concluded. It is still open to question whether PGD will be allowed at all or introduced with some limitations concerning the spectrum of indications.
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Strowitzki, T. Möglichkeiten und Grenzen der Präimplantationsdiagnostik. Gynäkologische Endokrinologie 1, 164–169 (2003). https://doi.org/10.1007/s10304-003-0043-4
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DOI: https://doi.org/10.1007/s10304-003-0043-4