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Effect of aqueous extract of date palm fruit (Phoenix dactylifera L.) on therapeutic index of amphotericin B

Effet de l’extrait aqueux des dattes (Phoenix dactylifera L.) sur l’index thérapeutique de l’amphotéricine B

  • Pharmacognosie
  • Published:
Phytothérapie

Abstract

The aim of this study was to identify the effect of aqueous extract of date palm fruit (Phoenix dactylifera L.) on therapeutic index of amphotericin B. The water extract of date fruit of Phoenix dactylifera were tested for the antifungal activity with amphotericin B against the yeast Candida albicans ATCC 1023. Secondly, we have tested the cytotoxicity of this complex on human red blood cells.

The results showed a significant improvement in the antifungal activity compared with amphotericin B alone at therapeutic concentration. Furthermore, the addition of aqueous extract protects human red blood cells against the cytotoxicity induced by amphotericin B. This is due probably, to the effect of flavonoïds and polysaccharides present in date fruit.

Résumé

Le but de cette étude est d’évaluer l’effet de l’extrait aqueux des dattes (Phoenix dactylifera L.) sur l’indice thérapeutique de l’amphotéricine B. L’extrait aqueux des dattes a été testé sur l’activité antifongique de l’amphotéricine B vis-à-vis de la levure Candida albicans ATCC 1023. En second lieu, nous avons modulé la cytotoxicité de ce complexe sur les globules rouges humains. Les résultats ont montré une amélioration significative de l’activité antifongique par rapport à l’amphotéricine B seul. En outre, l’addition de l’extrait aqueux protège les globules rouges humains contre la cytotoxicité induite par l’amphotéricine B. Cela est dû probablement à la présence des flavonoïdes et des polysaccharides dans l’extrait aqueux des dattes.

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Authors and Affiliations

  1. Antibiotics Antifungal Laboratory: Physical-Chemistry, Synthesis and Biological Activity, Department of Biology, Faculty of Sciences, Tlemcen University, Tlemcen, Algeria

    S. Belmir, K. Boucherit, Z. Boucherit-Otmani & M.-H. Belhachemi

Authors
  1. S. Belmir
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  2. K. Boucherit
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  3. Z. Boucherit-Otmani
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  4. M.-H. Belhachemi
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Correspondence to S. Belmir.

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Belmir, S., Boucherit, K., Boucherit-Otmani, Z. et al. Effect of aqueous extract of date palm fruit (Phoenix dactylifera L.) on therapeutic index of amphotericin B. Phytothérapie 14, 97–101 (2016). https://doi.org/10.1007/s10298-015-0961-z

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  • DOI: https://doi.org/10.1007/s10298-015-0961-z

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