Résumé
La propolis est une substance résineuse récoltée par les abeilles (Apis mellifera) dont la composition biochimique dépend de l’origine botanique. Cette revue dresse une liste non exhaustive des différentes propolis étudiées sur les différents continents avec leurs principaux composés. Les divers effets biologiques et/ou thérapeutiques attribués à la propolis et/ou à ses principaux constituants sont passés en revue. Enfin, bien que prometteur, un travail pour établir des critères de qualité reste indispensable.
Abstract
Propolis is a resinous substance gathered by honeybees (Apis mellifera) which biochemical composition depends on botanical sources. This review gives a no exhaustive list of different types of studied propolis around the world with its main constituents. Both several biological and/or therapeutic effects from propolis and/or its main constituents are reviewed. Finally, although the promising interest, a work is needed to establish the quality criteria of propolis.
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Références
Abdel-Fattah NS, Nada OH (2007) Effect of propolis versus metronidazole and their combined use in treatment of acute experimental giardiasis. J Egypt Soc Parasitol 37: 691–710
Ahn MR, Kumazawa S, Hamasaka T, et al. (2004) Antioxidant activity and constituents of propolis collected in various areas of Korea. J Agric Food Chem 52: 7286–7292
Ahn MR, Kunimasa K, Kumazawa S, et al. (2009) Correlation between antiangiogenic activity and antioxidant activity of various components from propolis. Mol Nutr Food Res 53: 643–651
Ahn MR, Kunimasa K, Ohta T, et al. (2007) Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Lett 252: 235–243
Alencar SM, Oldoni TL, Castro ML, et al. (2007) Chemical composition and biological activity of a new type of Brazilian propolis: red propolis. J Ethnopharmacol 113: 278–283
Alyane M, Kebsa LB, Boussenane HN, et al. (2008) Cardioprotective effects and mechanism of action of polyphenols extracted from propolis against doxorubicin toxicity. Pak J Pharm Sci 21: 201–209
Amoros M, Simoes CM, Girre L, et al. (1992) Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. J Nat Prod 55: 1732–1740
Avci CB, Gunduz C, Baran Y, et al. (2011) Caffeic acid phenethyl ester triggers apoptosis through induction of loss of mitochondrial membrane potential in CCRF-CEM cells. J Cancer Res Clin Oncol 137: 41–47
Bankova V (2005) Chemical diversity of propolis and the problem of standardization. J Ethnopharmacol 100: 114–117
Bankova V, Christov R, Kujumgiev A, et al. (1995) Chemical composition and antibacterial activity of Brazilian propolis. Z Naturforsch C 50: 167–172
Bankova VDA, Popov S, Evstatieva L, et al. (1992) Propolis produced in Bulgaria and Mongolia: phenolic compounds and plant origin. Apidologie 23: 79–85
Bankova VDA, Popov S, Evstatieva L, Kuleva L (1991) A study on the origin of bulgarian propolis. Apiacta 40: 13–17
Bankova VSCS, Marcucci MC (2000) Propolis: recent advances in chemistry and plant origin. Apidologie 31: 3–15
Banskota AH, Tezuka Y, Adnyana IK, et al. (2001) Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis. Phytomedicine 8: 16–23
Banskota AH, Tezuka Y, Kadota S (2001) Recent progress in pharmacological research of propolis. Phytother Res 15: 561–571
Benguedouar L, Boussenane HN, Wided K, et al. (2008) Efficiency of propolis extract against mitochondrial stress induced by antineoplasic agents (doxorubicin and vinblastin) in rats. Indian J Exp Biol 46: 112–119
Benkovic V, Knezevic AH, Dikic D, et al. (2009) Radioprotective effects of quercetin and ethanolic extract of propolis in gamma-irradiated mice. Arh Hig Rada Toksikol 60: 129–138
Bhadauria M, Nirala SK, Shukla S (2008) Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats. Food Chem Toxicol 46: 2703–2712
Bogdanov S (2010) Propolis: biological properties and medical applications. The propolis book chap 2
Boyanova L, Gergova G, Nikolov R, et al. (2005) Activity of Bulgarian propolis against 94 Helicobacter pylori strains in vitro by agar-well diffusion, agar dilution and disc diffusion methods. J Med Microbiol 54: 481–483
Burdock GA (1998) Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol 36: 347–363
Burke TR, Jr., Fesen MR, Mazumder A, et al. (1995) Hydroxylated aromatic inhibitors of HIV-1 integrase. J Med Chem 38: 4171–4178
Chen CN, Wu CL, Lin JK (2007) Apoptosis of human melanoma cells induced by the novel compounds propolin A and propolin B from Taiwenese propolis. Cancer Lett 245: 218–231
Chen CN, Wu CL, Shy HS, et al. (2003) Cytotoxic prenylflavanones from Taiwanese propolis. J Nat Prod 66: 503–506
Chopra S, Pillai KK, Husain SZ, et al. (1995) Propolis protects against doxorubicin-induced myocardiopathy in rats. Exp Mol Pathol 62: 190–198
Chung TW, Moon SK, Chang YC, et al. (2004) Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J 18: 1670–1681
Coelho LG, Bastos EM, Resende CC, et al. (2007) Brazilian green propolis on Helicobacter pylori infection. a pilot clinical study. Helicobacter 12: 572–574
Dalben-Dota KF, Faria MG, Bruschi ML, et al. (2010) Antifungal activity of propolis extract against yeasts isolated from vaginal exudates. J Altern Complement Med 16: 285–290
Daugsch A, Moraes CS, Fort P, et al. (2008) Brazilian red propolis — chemical composition and botanical origin. Evid Based Complement Alternat Med 5: 435–441
de Castro SL, Higashi KO (1995) Effect of different formulations of propolis on mice infected with Trypanosoma cruzi. J Ethnopharmacol 46: 55–58
Dobrowolski JW, Vohora SB, Sharma K, et al. (1991) Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic studies on propolis bee products. J Ethnopharmacol 35: 77–82
Dolci P, Ozino OI (2003) Study of the in vitro sensitivity to honey bee propolis of Staphylococcus aureus strains characterized by different sensitivity to antibiotics. Ann Microbiol 53: 233–243
El-Sayed el SM, Abo-Salem OM, Aly HA, et al. (2009) Potential antidiabetic and hypolipidemic effects of propolis extract in streptozotocin-induced diabetic rats. Pak J Pharm Sci 22: 168–174
Eom HS, Lee EJ, Yoon BS, et al. (2010) Propolis inhibits the proliferation of human leukaemia HL-60 cells by inducing apoptosis through the mitochondrial pathway. Nat Prod Res 24: 375–386
Farooqui T, Farooqui A (2010) Molecular mechanism underlying the therapeutic activities of propolis: a critical review. Curr Nutr Food Sci 6: 186–199
Fernandes Junior A, Balestrin EC, Betoni JE, et al. (2005) Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs. Mem Inst Oswaldo Cruz 100: 563–566
Gardana C, Scaglianti M, Pietta P, et al. (2007) Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 45: 390–399
Gardana C, Simonetti P (2011) Evaluation of allergens in propolis by ultra-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 25: 1675–1682
Gekker G, Hu S, Spivak M, et al. (2005) Anti-HIV-1 activity of propolis in CD4(+) lymphocyte and microglial cell cultures. J Ethnopharmacol 102: 158–163
Ghisalberti EL (1979) Propolis: a review. Bee World 60: 59–84
Giurcaneanu F, Crisan I, Esanu V, et al. (1988) Treatment of cutaneous herpes and herpes zoster with Nivcrisol-D. Virologie 39: 21–24
Gomez-Romero M, Arraez-Roman D, Moreno-Torres R, et al. (2007) Antioxidant compounds of propolis determined by capillary electrophoresis-mass spectrometry. J Sep Sci 30: 595–603
Gonzalez RR, Rodriguez D, Gonzalez S, et al. (1994) Hepatoprotective effects of propolis extract on paracetamol-induced liver damage in mice. Phytother Res 8: 229–232
Greenaway WST, Whatler FR (1990) The composition and plant origins of propolis. Bee World 71: 107–118
Gregoris E, Stevanato R (2010) Correlations between polyphenolic composition and antioxidant activity of Venetian propolis. Food Chem Toxicol 48: 76–82
Hernandez IM, Fernandez MC, Cuesta-Rubio O, et al. (2005) Polyprenylated benzophenone derivatives from Cuban propolis. J Nat Prod 68: 931–934
Huang WJ, Huang CH, Wu CL, et al. (2007) Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells. J Agric Food Chem 55: 7366–7376
Izuta H, Shimazawa M, Tsuruma K, et al. (2009) Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells. BMC Complement Altern Med 9: 45
Jasprica I, Mornar A, Debeljak Z, et al. (2007) In vivo study of propolis supplementation effects on antioxidative status and red blood cells. J Ethnopharmacol 110: 548–554
Kampa M, Alexaki VI, Notas G, et al. (2004) Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res 6: R63–R74
Keshavarz M, Mostafaie A, Mansouri K, et al. (2009) Inhibition of corneal neovascularization with propolis extract. Arch Med Res 40: 59–61
Khalil ML (2006) Biological activity of bee propolis in health and disease. Asian Pac J Cancer Prev 7: 22–31
Khayyal MT, el-Ghazaly MA, el-Khatib AS (1993) Mechanisms involved in the antiinflammatory effect of propolis extract. Drugs Exp Clin Res 19: 197–203
Khayyal MT, el-Ghazaly MA, el-Khatib AS, et al. (2003) A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Fundam Clin Pharmacol 17: 93–102
Koo H, Rosalen PL, Cury JA, et al. (2002) Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity. Antimicrob Agents Chemother 46: 1302–1309
Kujumgiev A, Tsvetkova I, Serkedjieva Y, et al. (1999) Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol 64: 235–240
Kumazawa S, Goto H, Hamasaka T, et al. (2004) A new prenylated flavonoid from propolis collected in Okinawa, Japan. Biosci Biotechnol Biochem 68: 260–262
Kumazawa SH, Nakayama T (2004) Antioxidant activity of propolis of various geographic origins. Food Chem 84: 329–339
Lahouel MFJ (2004) Role of flavonoids in the prevention of haematotoxicity due to chemotherapeutic agents. Haema 7: 313–320
Liao YR, Hsu JY, Chu JJ, et al. (2010) Caffeic acid phenethyl ester suppresses the induction of eotaxin in human lung fibroblast cells. J Asthma 47: 233–237
Liu AL, Wang HD, Lee SM, et al. (2008) Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorg Med Chem 16: 7141–7147
Lotfy M (2006) Biological activity of bee propolis in health and disease. Asian Pac J Cancer Prev 7: 22–31
Lu LC, Chen YW, Chou CC (2005) Antibacterial activity of propolis against Staphylococcus aureus. Int J Food Microbiol 102: 213–220
Machado GM, Leon LL, De Castro SL (2007) Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Mem Inst Oswaldo Cruz 102: 73–77
Marcucci MC (1995) Propolis: chemical composition, biological properties and therapeutic activity. Apidologie 26: 83–99
Montoro A, Barquinero JF, Almonacid M, et al. (2011) Concentration-dependent protection by ethanol extract of propolis against gamma-ray-induced chromosome damage in human blood lymphocytes. Evid Based Complement Alternat Med 174853
Murad JM, Calvi SA, Soares AM, et al. (2002) Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides brasiliensis. J Ethnopharmacol 79: 331–334
Najafi MF, Vahedy F, Seyyedin M, et al. (2007) Effect of the water extracts of propolis on stimulation and inhibition of different cells. Cytotechnology 54: 49–56
Okutan H, Ozcelik N, Yilmaz HR, et al. (2005) Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart. Clin Biochem 38: 191–196
Onlen Y, Tamer C, Oksuz H, et al. (2007) Comparative trial of different anti-bacterial combinations with propolis and ciprofloxacin on Pseudomonas keratitis in rabbits. Microbiol Res 162: 62–68
Orsatti CL, Missima F, Pagliarone AC, et al. (2010) Th1/Th2 cytokines’ expression and production by propolis-treated mice. J Ethnopharmacol 129: 314–318
Orsi ROF, Soares SRC, Calvi A, et al. (2000) Immunomodulatory action of propolis on macrophage activation. J Venom Anim Toxins 6: 205–219
Orsolic N (2010) A review of propolis antitumour action in vivo and in vitro. JAAS 2: 1–20
Ozcan M (2004) Inhibition of Aspergillus parasiticus NRRL 2999 by pollen and propolis extracts. J Med Food 7: 114–116
Padmavathi R, Senthilnathan P, Chodon D, et al. (2006) Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 dimethyl benz(a)anthracene-induced breast cancer in female Sprague Dawley rats. Life Sci 78: 2820–2825
Park JH, Lee JK, Kim HS, et al. (2004) Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. Int Immunopharmacol 4: 429–436
Park YK, Alencar SM, Aguiar CL (2002) Botanical origin and chemical composition of Brazilian propolis. J Agric Food Chem 50: 2502–2506
Park YK, Paredes-Guzman JF, Aguiar CL, et al. (2004) Chemical constituents in Baccharis dracunculifolia as the main botanical origin of southeastern Brazilian propolis. J Agric Food Chem 52: 1100–1103
Pavilonis A, Baranauskas A, Puidokaite L, et al. (2008) Antimicrobial activity of soft and purified propolis extracts. Medicina (Kaunas) 44: 977–983
Piccinelli AL, Lotti C, Campone L, et al. (2011) Cuban and Brazilian red propolis: botanical origin and comparative analysis by high-performance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry. J Agric Food Chem 59: 6484–6491
Popolo A, Piccinelli AL, Morello S, et al. (2011) Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells. Can J Physiol Pharmacol 89: 50–57
Popova M, Bankova V, Butovska D, et al. (2004) Validated methods for the quantification of biologically active constituents of poplar-type propolis. Phytochem Anal 15: 235–240
Popova MPBV, Bogdanov S, Tsvetkova I, et al. (2007) Chemical characteristics of poplar type propolis of different geographic origin. Apidologie 38: 306–311
Popova M, Trusheva B, Antonova D, et al. (2011) The specific chemical profile of Mediterranean propolis from Malta. Food Chem 126: 1431–1435
Popova M, Graikou K, Bankova V, et al. (2008) Chemical composition of 10 selected samples of Mediterranean propolis. Planta medica 74: 1100–1101
Popova M P, Graikou K, Chinou I, et al. (2010) GC-MS profiling of diterpene compounds in Mediterranean propolis from Greece. J Agric Food Chem 58: 3167–3176
Popravko SA (1978) Chemical composition of propolis, its origin and standardization. In: Remarkable Hive product: propolis. Apimondia, Bucarest, pp. 15–18
Raghukumar R, Vali L, Watson D, et al. (2010) Antimethicillin-resistant Staphylococcus aureus (MRSA) activity of’ pacific propolis’ and isolated prenylflavanones. Phytother Res 24: 1181–1187
Ramos AFN, Miranda JL (2007) Propolis: a review of its anti-inflammatory and healing actions. J Venom Anim Toxins Incl Trop Dis 13: 697–710
Rossi A, Ligresti A, Longo R, et al. (2002) The inhibitory effect of propolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages. Phytomedicine 9: 530–535
Salatino A, Teixeira EW, Negri G, et al. (2005) Origin and chemical variation of Brazilian propolis. Evid Based Complement Alternat Med 2: 33–38
Samet N, Laurent C, Susarla SM, et al. (2007) The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. Clin Oral Investig 11: 143–147
Santos VR, Gomes RT, de Mesquita RA, et al. (2008) Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res 22: 1544–1547
Sawaya AC, Abdelnur PV, Eberlin MN, et al. (2010) Fingerprinting of propolis by easy ambient sonic-spray ionization mass spectrometry. Talanta 81: 100–108
Scazzocchio F, D’Auria FD, Alessandrini D, et al. (2006) Multifactorial aspects of antimicrobial activity of propolis. Microbiol Res 161: 327–333
Schnitzler P, Neuner A, Nolkemper S, et al. (2010) Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother Res 24(Suppl 1): S20–S28
Sforcin JM (2007) Propolis and the immune system: a review. J Ethnopharmacol 113: 1–14
Sforcin JM, Bankova V (2011) Propolis: is there a potential for the development of new drugs J Ethnopharmacol 133: 253–260
Shimizu T, Hino A, Tsutsumi A, et al. (2008) Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. Antivir Chem Chemother 19: 7–13
Shinmei Y, Yano H, Kagawa Y, et al. (2009) Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. Immunopharmacol Immunotoxicol 31: 688–693
Silici S, Kutluca S (2005) Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region. J Ethnopharmacol 99: 69–73
Sobocanec S, Sverko V, Balog T, et al. (2006) Oxidant/antioxidant properties of Croatian native propolis. J Agric Food Chem 54: 8018–8026
Song YS, Park EH, Jung KJ, et al. (2002) Inhibition of angiogenesis by propolis. Arch Pharm Res 25: 500–504
Speciale A, Costanzo R, Puglisi S, et al. (2006) Antibacterial activity of propolis and its active principles alone and in combination with macrolides, beta-lactams and fluoroquinolones against microorganisms responsible for respiratory infections. J Chemother 18: 164–171
Stepanovic S, Antic N, Dakic I, et al. (2003) In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs. Microbiol Res 158: 353–357
Suzuki I, Hayashi I, Takaki T, et al. (2002) Antitumor and anticytopenic effects of aqueous extracts of propolis in combination with chemotherapeutic agents. Cancer Biother Radiopharm 17: 553–562
Szliszka E, Czuba ZP, Domino M, et al. (2009) Ethanolic extract of propolis (EEP) enhances the apoptosis-inducing potential of TRAIL in cancer cells. Molecules 14: 738–754
Tomás-Barberán FGV, Vit-Oliviera C, Ferreres P, Tomás-Lorente F (1993) Phytochemical evidence for the botanical origin of tropical propolis from Venezuela. Phytochemistry 34: 191–196
Trusheva B, Popova M, Koendhori E B, et al. (2011) Indonesian propolis: chemical composition, biological activity and botanical origin. Nat Prod Res 25: 606–613
Trusheva B, Popova M, Naydenski H, et al. (2004) New polyisoprenylated benzophenones from Venezuelan propolis. Fitoterapia 75: 683–689
Uzel A, Sorkun K, Oncag O, et al. (2005) Chemical compositions and antimicrobial activities of four different Anatolian propolis samples. Microbiol Res 160: 189–195
Valente MJ, Baltazar AF, Henrique R, et al. (2011) Biological activities of Portuguese propolis: protection against free radical-induced erythrocyte damage and inhibition of human renal cancer cell growth in vitro. Food Chem Toxicol 49: 86–92
Velikova M, Bankova V, Sorkun K, et al. (2000) Propolis from the Mediterranean region: chemical composition and antimicrobial activity. Z Naturforsch C 55: 790–793
Viuda-Martos M, Ruiz-Navajas Y, Fernandez-Lopez J, et al. (2008) Functional properties of honey, propolis, and royal jelly. J Food Sci 73: R117–R124
Vynograd N, Vynograd I, Sosnowski Z (2000) A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine 7: 1–6
Watabe M, Hishikawa K, Takayanagi A, et al. (2004) Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem 279: 6017–6026
Weng MS, Liao CH, Chen CN, et al. (2007) Propolin H from Taiwanese propolis induces G1 arrest in human lung carcinoma cells. J Agric Food Chem 55: 5289–5298
Xu BH, Shi MZ (2006) An in vitro test of propolis against Trichomonas vaginalis. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 24: 477–478
Yang HY, Chang CM, Chen YW, et al. (2006) Inhibitory effect of propolis extract on the growth of Listeria monocytogenes and the mutagenicity of 4-nitroquinoline-N-oxide. J Sci Food Agric 86: 937–943
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Cardinault, N., Cayeux, M.O. & Percie du Sert, P. La propolis : origine, composition et propriétés. Phytothérapie 10, 298–304 (2012). https://doi.org/10.1007/s10298-012-0733-y
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DOI: https://doi.org/10.1007/s10298-012-0733-y