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Phellinus linteus : un mycélium prometteur en cancérologie ou contre les désordres immunitaires

Phellinus linteus: a promising mycelium against cancer or immune disorders

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  • Mycothérapie
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Phytothérapie

Résumé

Le Phellinus linteus (PL) est un mycélium prometteur. Selon les études in vitro ou chez l’animal, ses polysaccharides diminuent le risque de métastases et favorisent l’apoptose de nombreuses lignées tumorales. Agent antiangio génétique et hépatoprotecteur, il favorise aussi l’apoptose induite par la doxorubicine. L’hispidine qu’il contient module l’équilibre TH1/TH2 et réduit la synthèse d’IgE. Elle réduit l’inflammation digestive ou articulaire et agit comme un antioxydant puissant. Un effet anti-TH17 expliquerait la protection des cellules de Langerhans. L’hispidine inhibe les bêtasécrétases essentielles dans la survenue de la maladie d’Alzheimer. Ces propriétés encore expérimentales ne sauraient rester longtemps sans application.

Abstract

Phellinus linteus (PL) is a promising mycelium according to in vitro or to animal studies, its polysaccharides decrease the risk of metastasis and favour the apoptosis of several tumour cells. PL is an anti-angiogenetic or a hepatoprotective agent and synergizes with doxorubicine. It contains hispidine, which modulates the TH1/TH2 balance et reduces the synthesis of IgE. PL reduces joint or gut inflammation and demonstrates anti-oxidative properties. An anti-TH17 effect could protect Langerhans cells. Hispidin inhibits beta-secretases, implicated in Alzheimer disease occurrence. These interesting experimental properties forecast clinical trials.

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    B. Donatini

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Donatini, B. Phellinus linteus : un mycélium prometteur en cancérologie ou contre les désordres immunitaires. Phytothérapie 9, 221–224 (2011). https://doi.org/10.1007/s10298-011-0642-5

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  • DOI: https://doi.org/10.1007/s10298-011-0642-5

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