Résumé
L’épine-vinette d’Espagne, Berberis hispanica Boiss. & Reut., est indiquée dans la pratique traditionnelle marocaine contre les inflammations, les affections hépatiques, les métrorragies et les désordres digestifs. Dans cette étude, nous avons démontré de très intéressants effets anti-dépresseurs, antinociceptifs et immunomodulateurs, suite à l’administration intrapéritonéale (IP) de l’extrait aqueux à 120mg/kg et protéique à 20 mg/kg de Berberis hispanica chez la souris. Ces effets pharmacologiques ont été étudiés en utilisant le modèle de la nage forcée « dépression », le test de la plaque chaude « nociception », et la technique de la cytométrie en flux « immunomodulation ». Ce travail rapporte d’éventuelles applications thérapeutiques de Berberis hispanica originaire du Maroc, en fonction de la procédure d’extraction entreprise, dans les traitements de certaines pathologies, à savoir la dépression, la douleur et les dysfonctionnements du système immunitaire.
Abstract
The Spain Barberry, Berberis hispanica Boiss. & Reut., is indicated in the traditional Moroccan medicine against inflammation, liver disease, bleeding and digestive disorders. In this study, we have shown an interesting antidepressive, antinociceptive and immunomodulatory effects after intraperitoneal (IP) administration of aqueous extract at 120mg/kg and proteic extract at 20mg/kg of Berberis hispanica. We have evaluated these pharmacological effects through the forced swimming model “depression”, the hot plate test “nociception” and flow cytometry technique “immunomodulation” in mouse. Depending on the extraction procedure, this work shows some possible therapeutic applications of Berberis hispanica from Morocco in the treatment of some diseases like depression, pain and immune system disturbances.
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Ce travail rapporte d’éventuelles applications thérapeutiques de Berberis hispanica originaire du Maroc, en fonction de la procédure d’extraction entreprise. Ce potentiel thérapeutique nécessite d’autres investigations complémentaires d’ordre clinique.
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Youbi, A.E.H.E., Bousta, D., Ouahidi, I. et al. Effets antidépresseurs, antinociceptifs et immunomodulateurs des extraits aqueux et protéique de Berberishispanica Boiss. & Reut. du Maroc. Phytothérapie 9, 25–32 (2011). https://doi.org/10.1007/s10298-010-0606-1
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DOI: https://doi.org/10.1007/s10298-010-0606-1