Skip to main content
SpringerLink
Log in

Effet antihypertenseur des feuilles d’Inula viscosa

Antihypertensive effect of an aqueous extract of Inula viscosa leaves

  • Article Original
  • Pharmacognosie
  • Published:
Phytothérapie

Résumé

L’effet antihypertenseur de l’extrait aqueux (EA) des feuilles d’Inula viscosa a été évalué sur des rats rendus hypertendus par un traitement au L-NAME (NG-nitro-L-arginine méthyle ester). L’évolution de la pression artérielle est évaluée en mesurant la pression artérielle systolique (PAS) à l’aide d’un plétysmographe. Nos investigations ont porté sur trois groupes de rats: un groupe témoin, un groupe traité au L-NAME (30 mg/kg par jour) et un groupe traité au L-NAME (30 mg/kg par jour) et à l’EA d’Inula viscosa à 250 mg/kg par jour. Après quatre semaines de traitement, on note un développement de l’hypertension artérielle (HTA) chez le groupe traité au L-NAME (PAS = 164 ± 3 mmHg), alors que le groupe recevant le L-NAMEet l’EA d’Inula viscosa a développé une PAS de 145 ± 2 mmHg seulement. Ces résultats montrent un effet antihypertenseur de cet extrait. De plus, l’étude de l’effet cardiaque de l’EA d’Inula viscosa sur le modèle de coeur isolé et perfusé de rats selon la méthode de Langendorff a montré un effet inotrope négatif dosedépendant qui pourrait expliquer en partie l’effet antihypertenseur trouvé.

Abstract

Inula viscosa (Asteraceae) is amedicinal plant widely used by Mediterranean population in folk medicine to treat different diseases. The antihypertensive effect of the aqueous extract obtained from Inula viscosa leaves was studied in hypertensive rats. Systolic blood pressure was measured using the indirect tail-cuff plethysmographic method (TCP). Three groups of rats were used: control group received water; L-NAME treated group received NG-nitro-L-arginine methylester (30 mg/kg per day) and group received simultaneously L-NAME (30 mg/kg per day) and aqueous extract of Inula viscose (250 mg/kg per day). After four weeks of treatment, the group receiving the L-NAME alone have developed an arterial hypertension (systolic blood pressure (SBP) = 164 ± 3 mmHg), whereas the group receiving the L-NAME and the aqueous extract of Inula viscosa have developed a SBP of 145 ± 2 mmHg. These results showed that the studied extract prevented significantly the development of hypertension induced by L-NAME. Moreover, the study of the cardiac effect of the Inula viscosa aqueous extract on the model of isolated and perfused rat heart, according to the method of Langendorff, showed a dose-dependent negative inotropic effect, which may contribute to antihypertensive effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Références

  1. Ali-Shtayeh MS, Abu Ghdeib SI (1999) Antifungal activity of plant extracts against dermatophytes. Mycoses 42:665–672

    Article  CAS  PubMed  Google Scholar 

  2. Ali-Shtayeh MS, Yaghmour RMR, Faidi YR, et al (1998) Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area. J Ethnopharmacol 60:265–271

    Article  CAS  PubMed  Google Scholar 

  3. Al Dissi NM, Salhab AS, Al Hajj HA (2001) Effects of Inula viscosa leaf extracts on abortion and implantation in rats. J Ethnopharmacol 77:117–121

    Article  Google Scholar 

  4. Bailey C, Day C, Leatherdal B (1986) Traditional treatments for diabetes from Asia and West Indies. Pract Diabet 3:190–194

    Article  Google Scholar 

  5. Benayache S, Benayache F, Dendougui H, Jay M (1991) Flavonoids of Inula viscosa. Plant Med Phytother 25:170–176

    CAS  Google Scholar 

  6. Bonnet D, Aggoun Y (2002) Facteurs de risque cardiovasculaire connus (HTA, diabète, hypercholestérolémie): prévention secondaire et tertiaire dès l’âge pédiatrique. Arch Pediatr 9:131–133

    Article  Google Scholar 

  7. Bunag RD (1973) Validation in awaked rats of a tail cuff method for measuring systolic pressure. J Appl Physiol 34:279–282

    CAS  PubMed  Google Scholar 

  8. Cohen Y, Baider A, Ben-Daniel BH, Ben-Daniel Y (2002) Fungicidal preparations from Inula viscosa. Plant Prot Sci 38:629–630

    Google Scholar 

  9. CSTROUA (1985) Pharmacopée africaine, l’Cd., Lagos, pp. 4–8

  10. Day C, Bailey CA (1988) Diabetologist’s herbal. Med Lit Diabetes Ray Soc Med 5:31–34

    Google Scholar 

  11. Duarte J, Perez-Vizcaino F, Utrilla P, et al (1993) Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. General Pharmacol 24(4):857–862

    CAS  Google Scholar 

  12. Eddouks M, Maghrani M, Lemhadri A, et al (2002) Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the southeast region of Morocco (Tafilalet). J Ethnopharmacol 82:97–103

    Article  CAS  PubMed  Google Scholar 

  13. Etou-Ossibi AW, Nzonzi J, Mombouli JV, et al (2005) Screening chimique et effets de l’extrait aqueux du Lippia multiflora Moldenke sur le coeur isole? du crapaud. Phytothérapie 5:193–199

    Article  Google Scholar 

  14. Gilani A, Aftab K, Surea A (1994) Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytother Res 8:87–91

    Article  CAS  Google Scholar 

  15. Hennebelle T, Sahpaz S, Bailleul F (2004) Polyphénols végétaux, sources, utilisations et potentiel dans la lutte contre le stress oxydatif. Phytothérapie 2:3–6

    Article  CAS  Google Scholar 

  16. Lauro L, Rolih C (1990) Observations and research on an extract of Inula viscosa Ait. Boll Soc Ital Biol Sper 66:829–834

    CAS  PubMed  Google Scholar 

  17. Legssyer A, Ziyyat A, Mekhfi H, et al (2004) Tannins and catechin gallate mediate the vasorelaxant effect of Arbutus unedo on the rat isolated aorta. Phytother Res 18:889–894

    Article  CAS  PubMed  Google Scholar 

  18. Legssyer A, Ziyyat A, Mekhfi H, et al (2002) Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta. Phytother Res 16:503–507

    Article  PubMed  Google Scholar 

  19. Martin N, Bardisa L, Vargas M, Guesada P (1994) Anti-arrhythmic profile of garlic dialysate assayed in dogs and isolated atrial preparations. J Ethnopharmacol 43:1–8

    Article  CAS  PubMed  Google Scholar 

  20. Melis M (1995) Chronic administration of aqueous extract of Stevia rebaudiana in rat: renal effect. J Ethnopharmacol 47:192–234

    Article  Google Scholar 

  21. Ouédraogo S, Traoré A, Somé N, et al (2005) Cardiovascular properties of aqueous extract from Tapinanthus dodoneifolius DC danser. Afr J Trad CAM 2:25–30

    Google Scholar 

  22. Rigaud AS, Hanon O, Bouchacourt P, Forette F (2001) Les complications cérébrales de l’hypertension artérielle chez le sujet âgé. Rev Med Interne 22:959–968

    Article  CAS  PubMed  Google Scholar 

  23. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR (1989) Evolution of traditional plant treatments for diabetes: studies on streptozotocin diabetic mice. Acta Diabetol Lat 26:51–55

    Article  CAS  PubMed  Google Scholar 

  24. Dimoa T, Nguelefacka TB, Kamtchouinga P, et al (1999) Effets hypotensifs de l’extrait au méthanol de Bidens pilosa Linn chez les rats hypertendus. Sci Vie 322:323–329

    Google Scholar 

  25. Vanhoutte P (2003) Vascular nitric oxide. Am Heart Assoc 67:572–575

    CAS  Google Scholar 

  26. Wollenweber E, Mayer K, Roitman JN (1991) Exudate flavonoids of Inula viscose. Phytochem 30:2445–2446

    Article  CAS  Google Scholar 

  27. Yegen O, Berger B, Heitefuss R (1992) Investigations on the fungitoxicity of extracts of 6 selected plants from Turkey against phytopathogenic fungi. Z. Pflanzenkrank. Pflanzenschutz. J Plant Dis Prot 99:349–359

    CAS  Google Scholar 

  28. Yaniv Z, Dafni A, Friedman J, Palevitch D (1987) Plants used for the treatment of diabetes in Israel. J Ethnopharmacol 19:145–151

    Article  CAS  PubMed  Google Scholar 

  29. Yasuroni M, Masayki N, Munchisa A, et al (1994) Hypotensive activity of ovadioledes isolated from Chinese crude drug fang-fing. Cao. Phytother Res 8:482–484

    Article  Google Scholar 

  30. Zimmer HG (1998) The isolated perfused heart and its pioneers. N Physiol Sci 13:203–210

    Google Scholar 

  31. Ziyyat A, Legssyer A, Mekhfi H, et al (1997) Phytotherapy of hypertension and diabetes in Oriental Morocco. J Ethnopharmacol 58:45–54

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de physiologie et ethnopharmacologie, faculté des sciences d’Oujda, Oujda, Maroc

    J. Kattouf, M. Belmoukhtar, H. Mekhfi, A. Ziyyat, M. Aziz, M. Bnouham & A. Legssyer

  2. Laboratoire de biochimie, faculté des sciences d’Oujda, Oujda, Maroc

    H. Harnafi

Authors
  1. J. Kattouf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Belmoukhtar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Harnafi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Mekhfi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Ziyyat
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Aziz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. Bnouham
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. Legssyer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. Kattouf.

About this article

Cite this article

Kattouf, J., Belmoukhtar, M., Harnafi, H. et al. Effet antihypertenseur des feuilles d’Inula viscosa . Phytothérapie 7, 309–312 (2009). https://doi.org/10.1007/s10298-009-0517-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10298-009-0517-1

Mots clés

Keywords

Search

Navigation