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Effets pharmacologiques de Ziziphus mauritiana Lam. (Rhamnacées) sur la pression artérielle de lapin

Pharmacological effects of Ziziphus mauritiana Lam. (Rhamnacees) onblood pressure in rabbits

  • Article Original
  • Pharmacognosie
  • Published:
Phytothérapie

Rësumé

L’extrait aqueux de Ziziphus mauritiana (Zm) dans un intervalle de doses compris entre 0,4 et 122 mg/kg de PC provoque chez le lapin une hypotension dose-dépendante comparable à celle de l’acétylcholine (Ach). En présence de doses croissantes d’atropine comprises entre 4,10−3 et 4,84 μg/kg de PC, l’hypotension induite par l’acétylcholine (Ach) à 4,10−3 et par Zm à 22 mg/kg de PC chez le lapin est progressivement inhibée. Cette inhibition est totale pour l’acétylcholine quand l’atropine est dosée à 4,84 μg/kg de PC, tandis qu’elle est partielle pour Ziziphus mauritiana même à cette concentration. Ces résultats suggèrent que certains principes actifs contenus dans l’extrait brut de Ziziphus mauritiana seraient des substances cholinomimétiques de type muscarinique. En conclusion, ces travaux justifient, au moins en partie, l’utilisation par les tradithérapeutes africains de Ziziphus mauritiana dans le traitement de l’hypertension artérielle.

Abstract

The extract Zizyphus mauritiana (Zm) in the dose range 0.4 to 122 mg/kg Pc, causes dose-dependent hypotension in rabbits, similar to that achieved with acetylcholine (ACh). In the presence of increasing doses of atropine, ranging from 4.10−3 to 4.84 μg/kg PC, hypotension induced in rabbits by acetylcholine (ACh) at 4.10−3 and ZM at 22 mg/kg at PC is progressively inhibited. This inhibition is total for acetylcholine when atropine is dosed at 4.84 μg/kg PC, while it is partial for Zizyphus mauritiana even at this concentration. These results suggest that some of the active ingredients contained in the crude extract of Zizyphus mauritiana might be cholinomimetic substances of the muscarinic type. In conclusion, this work justifies, at least partially, the use by African tradipractitioners of Zizyphus mauritiana in the treatment of hypertension.

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Authors and Affiliations

  1. Laboratoire de physiologie animale, UFR biosciences, université d’Abidjan-Cocody, 22 BP 582, Abidjan 22, Côte d’Ivoire

    F. Traore

  2. Laboratoire de pharmacognosie, UFR des sciences pharmaceutiques et biologiques, université d’Abidjan-Cocody, 01 BP V34, Abidjan 01, Côte d’Ivoire

    A. Koffi & A. L. Adjoungoua

  3. Laboratoire de biochimie et biologie de la reproduction, UFR des sciences pharmaceutiques et biologiques, université d’Abidjan-Cocody, 01 BP V34, Abidjan 01, Côte d’Ivoire

    F. Diafouka

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  1. A. Koffi
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  2. F. Traore
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  3. A. L. Adjoungoua
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  4. F. Diafouka
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Correspondence to F. Traore.

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Koffi, A., Traore, F., Adjoungoua, A.L. et al. Effets pharmacologiques de Ziziphus mauritiana Lam. (Rhamnacées) sur la pression artérielle de lapin. Phytothérapie 6, 219–227 (2008). https://doi.org/10.1007/s10298-008-0322-2

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  • DOI: https://doi.org/10.1007/s10298-008-0322-2

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