Résumé
Le présent travail évalue le potentiel hypotensif et les mécanismes d’action associés de l’extrait semi-éthanolique de Biophytum petersianum chez le rat Wistar normotendu. La méthode sanglante est utilisée pour mesurer la pression artérielle. L’extrait est administré par v.i. aux doses uniques de 27, 54 et 81 mg/kg. L’extrait à 54 mg/kg et la clonidine à 0,5 mg/kg sont administrés à des animaux différents, suivie d’une bi-occlusion carotidienne. La même dose d’extrait est administrée après bivagotomie et blocage des récepteurs muscariniques par l’atropine. Les résultats montrent que l’effet hypotenseur de l’extrait ne passe pas par l’inhibition du système nerveux sympathique mais implique partiellement la stimulation du système parasympathique puisque cet effet est bloqué par l’atropine. Ces résultats confirment l’utilisation traditionnelle de B. petersianum dans le traitement de l’hypertension.
Abstract
The aim of the study was to investigate the hypotensive effect and the mechanism underlying a semiethanolic extract of Biophytum petersianum on normal Wistar rats. The invasive method was used to measure arterial blood pressure. The extract was administered by I.V. in single doses of 27, 54 and 81 mg/kg. An extract (54 mg/kg) and a clonidine (0.5 mg/kg) were administered to different rats, followed by double carotid occlusion. The same extract dose was used after bivagotomy and muscarinic receptor blockade.
The results showed that the hypotensive effect of the extract was not a result of sympathetic nervous system inhibition but partially involved parasympathetic system stimulation, since this effect is blocked by atropine. These results confirm the traditional use of B. petersianum in the treatment of hypertension.
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Titrikou, S., Eklu-Gadegbeku, K., Aklikokou, K.A. et al. Effets de Biophytum petersianum (Oxalidaceae) sur la pression artérielle chez le rat Wistar. Phytothérapie 6, 215–218 (2008). https://doi.org/10.1007/s10298-008-0321-3
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DOI: https://doi.org/10.1007/s10298-008-0321-3