Skip to main content
SpringerLink
Log in

Influence de deux compléments alimentaires marins à forte teneur en calcium sur le métabolisme du calcium et sur un marqueur biochimique de la résorption de la masse osseuse

Effects of two high-calcium, marine dietary supplements on calcium metabolism and a biochemical marker of bone resorption

  • Article original
  • Des compléments alimentaires
  • Published:
Phytothérapie

Résumé

L’objectif de cette étude est d’évaluer l’influence de deux compléments alimentaires à forte teneur en calcium: des arêtes de poisson en poudre (Phoscalim®) et un hydrolysat de cartilage de raie (Glycollagène®), comparativement à du lait (élément de référence pour le calcium) et à un placebo (maltodextrine). Vingt hommes volontaires sains ont reçu 836 mg de calcium provenant des quatre produits étudiés. Le test de charge orale en calcium a permis de mesurer l’élévation du calcium et du phosphore sanguin et urinaire ainsi que la concentration plasmatique en parathormone et en télopeptides C du sérum.

Les résultats de cette étude montrent que les compléments alimentaires de source marine ont des effets sur la biodisponibilité calcique comparables à ceux du lait; d’autre part, les sources marines de calcium s’opposent à la résorption osseuse à court terme.

Abstract

The objective of this study was to evaluate the effects of two high-calcium, marine dietary supplements — a fishbone powder (Phoscalim®) and a ray cartilage hydrolysate (Glycollagene®) — compared with milk (calcium reference) and a placebo (maltodextrin). Twenty healthy male volunteers were randomised to receive 836 mg of calcium from four different sources. An increase in serum and urinary calcium and parathormone, as well as parathyroid hormone (iPTH) and serum C telopeptides (s-CTx), was studied using the oral calcium load test.

This study showed that dietary supplements from marine sources have effects on calcium bioavailability comparable to milk. On the other hand, marine calcium sources might prevent bone resorption in short term.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Bibliographie

  1. Beck AB, Bugel S, Sturup S, et al. (2003) A novel dual radio and stable isotope method for measuring calcium absorption in human: comparison with the whole body radio isotope retention method. Am J Clin Nutr 77: 399–405

    PubMed  CAS  Google Scholar 

  2. Dodiuk-Gad RP, Rozen GS, Rennert G, et al. (2005) Sustained effect of short-term calcium supplementation on bone mass in adolescent girls with low calcium intake. Am J Clin Nutr 81: 168–174

    PubMed  CAS  Google Scholar 

  3. Fardellone P, Bellony R, Brazier M, et al. (1993) Étude de la biodisponibilité du calcium: de l’emmental par rapport au bicarbonate de calcium. Cah Nutr Diet 28: 245–249

    CAS  Google Scholar 

  4. Flynn A (2003) The role of dietary calcium in bone health. Proc Nutr Soc 62: 851–858

    Article  PubMed  CAS  Google Scholar 

  5. Green JH, Booth C, Bunning R (2003) Acute effect of high calcium milk with or without additional magnesium, or calcium phosphate or parathyroid hormone and biochemical markers of bone resorption. Eur J Clin Nutr 57: 61–68

    Article  PubMed  CAS  Google Scholar 

  6. Heaney RP, Recker RR, Hinders SM (1988) Variability of calcium absorption. Am J Clin Nutr 47: 262–264

    PubMed  CAS  Google Scholar 

  7. Heaney RP (2000) Dietary protein and phosphorus do not effect calcium absorption. Am J Clin Nutr 72: 758–761

    PubMed  CAS  Google Scholar 

  8. Karkkainen MUM, Lamber G, Allargt CJE, et al. (2001) Does it make a difference low and when you take your calcium? The acute effects of calcium on calcium and bone metabolism. Am J Clin Nutr 74: 335–342

    PubMed  CAS  Google Scholar 

  9. Martin A (2001) Les apports nutritionnels conseillés pour la population française. Tec&Doc (édit.), Paris

  10. Martini L, Wood RJ (2002) Relative bioavailability of calcium rich dietary sources in the elderly. Am J Clin Nutr 76: 1345–1350

    PubMed  CAS  Google Scholar 

  11. Matkovic V, Goel PK, Badenhop-Stevens NE, et al. (2005) Calcium supplementation and bone universal density in females from childhood to young adulthood: a randomised controlled trial. Am J Clin Nutr 81: 175–188

    PubMed  CAS  Google Scholar 

  12. Nicar MJ, Pak Cy C (1985) Calcium bioavailability from calcium carbonate and calcium citrate. J Clin Endocrinol Metab 61: 391–393

    Article  PubMed  CAS  Google Scholar 

  13. Pak Cy C, Kaplan R, Bone H, et al. (1975) A simple test for the diagnosis of absorptive, resorptive and renal hypercalciuria. N Engl J Med 292: 497–500

    Article  PubMed  Google Scholar 

  14. Qvist P, Christgau S, Pedersen J, et al. (2005) Circadian variation in serum concentration of C-terminal telopeptide of type I collagen (serum CTX): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting. Bone 31: 57–61

    Article  Google Scholar 

  15. Reginster JY, Denis D, Bartsch V, et al. (1993) Acute biochemical variations induced by four different calcium salts in healthy male volunteers. Osteoporosis Int 3: 271–275

    Article  CAS  Google Scholar 

  16. Sadideen H, Swaminathan R (2004) Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects: an overnight study. Am J Clin Nutr 58: 1161–1165

    Google Scholar 

  17. Schaafsma F (1997) Bioavailability of calcium and magnesium. Eur J Clin Nutr 51(suppl): S13–S16

    PubMed  Google Scholar 

  18. Scopacasa F, Whishart JM, Horowitz M, et al. (2004) Relation between calcium absorption and serum calcitriol in normal men: evidence for age related — intestinal resistance to calcitriol. Eur J Clin Nutr 58: 264–269

    Article  PubMed  CAS  Google Scholar 

  19. Wolf RL, Cavley JA, Baker CE, et al. (2000) Factors associated with calcium absorption efficiency in pre and perimenopausal women Am J Clin Nutr 72: 466–471

    PubMed  CAS  Google Scholar 

  20. Zerwekh JE, Sakhae K, Pak Cy C (1981) Utility and limitation of calciuric response to oral calcium load as a measure of intestinal calcium absorption, comparison with isotopic fractional calcium absorption. Invest Urol 19: 161–164

    PubMed  CAS  Google Scholar 

  21. Zikan V, Haas T, Stepan JJ (2001) Acute effects in healthy women of oral calcium on the calcium-parathyroid axis and bone resorption as assessed by serum beta-CrossLaps. Calcif Tissue Int 68: 352–357

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de nutrition, Institut Pasteur de Lille, 1, rue du Professeur-Calmette, BP 245, 59019, Lille Cedex, France

    J. -M. Lecerf, B. Boukandoura, L. Hourez, A. Cazeele & B. Borgiès

  2. Centre d’investigation clinique, CHRU — Inserm 9301, 59008, Lille, France

    C. Lamotte & C. Libersa

  3. Centre de traitement des produits de la pêche (CTPP)/COPALIS, BP 239, 62203, Boulogne-sur-Mer, France

    C. Delannoy

Authors
  1. J. -M. Lecerf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Lamotte
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Boukandoura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Hourez
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Cazeele
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Libersa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. C. Delannoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. B. Borgiès
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. -M. Lecerf.

About this article

Cite this article

Lecerf, J.M., Lamotte, C., Boukandoura, B. et al. Influence de deux compléments alimentaires marins à forte teneur en calcium sur le métabolisme du calcium et sur un marqueur biochimique de la résorption de la masse osseuse. Phytothérapie 5 (Suppl 1), 32–37 (2007). https://doi.org/10.1007/s10298-007-0232-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10298-007-0232-8

Mots clés

Keywords

Search

Navigation