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Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

  • Metabolic Engineering and Synthetic Biology - Original Paper
  • Published:
Journal of Industrial Microbiology & Biotechnology

Abstract

Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides.

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Acknowledgements

This work was supported by a National Research Foundation of Korea grant (2016R1A2A1A05005078) (Y.J.Y.) funded by the Ministry of Science and ICT, the High Value-Added Food Technology Development Program funded by the Ministry of Agriculture, Food, and Rural Affairs (114019052SB010) (Y.J.Y.), a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare (HI18C1664) (Y.J.Y.), the Collaborative Genome Program of the Korea Institute of Marine Science and Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries (MOF) (No.20180430) (Y.J.Y.), and the Cooperative Research Program for Agriculture Science and Technology Development (PJ01317901) (J.W.P.) funded by the Rural Development Administration, Republic of Korea.

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  1. School of Biosystem and Biomedical Science, Korea University, Seoul, 02841, Republic of Korea

    Je Won Park

  2. Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea

    Yeo Joon Yoon

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This article is part of the Special Issue “Natural Product Discovery and Development in the Genomic Era 2019”.

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Park, J.W., Yoon, Y.J. Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones. J Ind Microbiol Biotechnol 46, 445–458 (2019). https://doi.org/10.1007/s10295-018-2095-4

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