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The many roles of glutamate in metabolism

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Journal of Industrial Microbiology & Biotechnology

Abstract

The amino acid glutamate is a major metabolic hub in many organisms and as such is involved in diverse processes in addition to its role in protein synthesis. Nitrogen assimilation, nucleotide, amino acid, and cofactor biosynthesis, as well as secondary natural product formation all utilize glutamate in some manner. Glutamate also plays a role in the catabolism of certain amines. Understanding glutamate’s role in these various processes can aid in genome mining for novel metabolic pathways or the engineering of pathways for bioremediation or chemical production of valuable compounds.

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  1. Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL, 61801, USA

    Mark C. Walker & Wilfred A. van der Donk

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Correspondence to Wilfred A. van der Donk.

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Special Issue: Natural Product Discovery and Development in the Genomic Era. Dedicated to Professor Satoshi Ōmura for his numerous contributions to the field of natural products.

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Walker, M.C., van der Donk, W.A. The many roles of glutamate in metabolism. J Ind Microbiol Biotechnol 43, 419–430 (2016). https://doi.org/10.1007/s10295-015-1665-y

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  • DOI: https://doi.org/10.1007/s10295-015-1665-y

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