Journal of Industrial Microbiology & Biotechnology

, Volume 39, Issue 2, pp 227–241

Protein engineering towards natural product synthesis and diversification


DOI: 10.1007/s10295-011-1044-2

Cite this article as:
Zabala, A.O., Cacho, R.A. & Tang, Y. J Ind Microbiol Biotechnol (2012) 39: 227. doi:10.1007/s10295-011-1044-2


A dazzling array of enzymes is used by nature in making structurally complex natural products. These enzymes constitute a molecular toolbox that may be used in the construction and fine-tuning of pharmaceutically active molecules. Aided by technological advancements in protein engineering, it is now possible to tailor the activities and specificities of these enzymes as biocatalysts in the production of both natural products and their unnatural derivatives. These efforts are crucial in drug discovery and development, where there is a continuous quest for more potent agents. Both rational and random evolution techniques have been utilized in engineering these enzymes. This review will highlight some examples from several large families of natural products.

Copyright information

© Society for Industrial Microbiology 2011

Authors and Affiliations

  • Angelica O. Zabala
    • 1
  • Ralph A. Cacho
    • 1
  • Yi Tang
    • 1
    • 2
  1. 1.Department of Chemical and Biomolecular EngineeringUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Chemistry and BiochemistryUniversity of CaliforniaLos AngelesUSA

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