To investigate gastrointestinal function in dementia with Lewy bodies and Parkinson disease.
We examined gastric emptying and colonic transit time in 19 dementia with Lewy bodies and 46 Parkinson disease patients.
Gastric emptying was longer in dementia with Lewy bodies than in Parkinson disease (p = 0.014). Colonic transit time tended to be longer in dementia with Lewy bodies than in Parkinson disease. There was no relationship between gastric emptying and colonic transit time, nor between gastric emptying, colonic transit time and age.
Gastric emptying was prolonged in dementia with Lewy bodies compared to Parkinson disease.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M; Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65: 1863–1872
Goodman RA, Lochner KA, Thambisetty M et al (2017) Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011–2013. Alzheimers Dement. 13:28–37
Orme T, Guerreiro R, Bras J (2018) The genetics of dementia with Lewy bodies: current understanding and future directions. Curr Neurol Neurosci Rep. 18:67. https://doi.org/10.1007/s11910-018-0874-y
Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184
Pfeiffer RF (2018) Gastrointestinal dysfunction in Parkinson’s disease. Curr Treat Options Neurol. 20:54. https://doi.org/10.1007/s11940-018-0539-9
Knudsen K, Szwebs M, Hansen AK, Borghammer P (2018) Gastric emptying in Parkinson’s disease: a mini-review. Parkinsonism Relat Disord. 55:18–25
Sakakibara R, Tateno F, Aiba Y, Ogata T, Kishi M, Terada H, Inaoka T, Nakatsuka T, Matsuoka K. MIBG myocardial scintigraphy identifies premotor PD/DLB during a negative DAT scan period: second report. Mov Disord Clinical Pract 2019: in press
Sakakibara R, Odaka T, Uchiyama T, Asahina M, Yamaguchi K, Yamaguchi T, Yamanishi T, Hattori T (2003) Colonic transit time and rectoanal videomanometry in Parkinson’s disease. J Neurol Neurosurg Psychiatry 74:268–272
Doi H, Sakakibara R, Sato M, Masaka T, Kishi M, Tateno A, Tateno F, Tsuyusaki Y, Takahashi O (2012) Plasma levodopa peak delay and impaired gastric emptying in Parkinson’s disease. J Neurol Sci 319:86–88
Folstein M, Folstein S, McHugh PR (1975) Mini-mental state; a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198
Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, Vantrappen G (1993) Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 104:1640–1647
Nakada K, Aoyama N, Nakagawa M, Kawasaki N, Shirasaka D, Zai H, Urita Y, Kitagawa Y, Koyama S, Shishido T, Kusunoki H, Kato M, Hanyu N, Haruma K, Hongo M (2002) The report of the workshop entitled “The present and the future in gastric emptying study assessed by 13C breath test: with special reference to the standardization of the method” at the 44th Annual Meeting of the Japanese Smooth Muscle Society. J Smooth Muscle Res 6:75–91
Devroede G (1993) Radiopaque marker measurement of colorectal transit. In: Schuster MM (ed) Atlas of gastrointestinal motility in health and disease, Chapter 3. Williams and Wilkins, Baltimore, pp 57–75
Sakakibara R, Doi H, Fukudo S. Lewy body constipation. J Anus Rectum, 2018: in press
Shannon K, Vanden Berghe P (2018) The enteric nervous system in PD: gateway, bystander victim, or source of solutions. Cell Tissue Res 373:313–326
Abbott RD, Petrovitch H, White LR, Masaki KH, Tanner CM, Curb JD et al (2001) Frequency of bowel movements and the future risk of Parkinson’s disease. Neurology 57:456–462
Giancola F, Torresan F, Repossi R, Bianco F, Latorre R, Ioannou A, De Giorgio R (2016) Downregulation of neuronal vasoactive intestinal polypeptide in Parkinson’s disease and chronic constipation. Neurogastroenterol Motility 29:e12995. https://doi.org/10.1111/nmo.12995
Svensson E, Horváth-Puhó E, Thomsen RW, Djurhuus JC, Pedersen L, Borghammer P, Sørensen HT (2015) Vagotomy and subsequent risk of Parkinson’s disease. Ann Neurol 78:522–529
Kujawska M, Jodynis-Liebert J (2018) What is the evidence that Parkinson’s disease is a prion disorder, which originates in the gut? Int J Mol Sci. 19(11):22. https://doi.org/10.3390/ijms19113573
Lee HJ, Jung KW, Chung SJ, Hong SM, Kim J, Lee JH, Hwang SW, Ryu HS, Kim MJ, Lee HS, Seo M, Park SH, Yang DH, Ye BD, Byeon JS, Choe J, Jung HY, Yang SK, Myung SJ. Relation of enteric α-synuclein to gastrointestinal dysfunction in patients with Parkinson’s disease and in neurologically intact subjects. J Neurogastroenterol Motil. 2018; 24:469–478
Liddle RA (2018) Parkinson’s disease from the gut. Brain Res 1693(Pt B):201–206
Anselmi L, Toti L, Bove C, Hampton J, Travagli RA (2017) A nigrolvagal pathway controls gastric motility and is affected in a rat model of parkinsonism. Gastroenterology 153:1581–1593
Sakakibara Y, Asahina M, Suzuki A, Hattori T (2009) Gastric myoelectrical differences between Parkinson’s disease and multiple system atrophy. Mov Disord 24:1579–1586
Goetze O, Nikodem AB, Wiezcorek J, Banasch M, Przuntek H, Mueller T, Schmidt WE, Woitalla D (2006) Predictors of gastric emptying in Parkinson’s disease. Neurogastroenterol Motil 18:369–375
Merchant HA, Liu F, Orlu Gul M, Basit AW (2016) Age-mediated changes in the gastrointestinal tract. Int J Pharm 512:382–395
Fich A, Camilleri M, Phillips SF (1989) Effect of age on human gastric and small bowel motility. J Clin Gastroenterol 11:416–420
Tateno F, Sakakibara R, Kishi M, Ogawa E, Yoshimatsu Y, Takada N, Suzuki Y, Mouri T, Uchiyama T, Yamamoto T (2011) Incidence of emergency intestinal pseudo-obstruction in Parkinson’s disease. J Am Geriatr Soc 59:2373–2375
Conflict of interest
None of the authors have any conflicts of interest to declare.
About this article
Cite this article
Doi, H., Sakakibara, R., Masuda, M. et al. Gastrointestinal function in dementia with Lewy bodies: a comparison with Parkinson disease. Clin Auton Res 29, 633–638 (2019). https://doi.org/10.1007/s10286-019-00597-w
- Dementia with Lewy bodies
- Parkinson disease
- Gastric emptying
- Colonic transit time