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The neurobiology of human crying


The production of emotional tears appears to be uniquely present in Homo sapiens. Despite the ubiquity of this human behavior, research is only just beginning to uncover the neurobiologic underpinnings of human emotional crying. In this article, we review the current state of the literature investigating the neurobiologic aspects of this uniquely human behavior, including the neuroanatomical, neurochemical, and psychophysiologic findings. To set the context for this review, we first provide a brief overview of the evolutionary background and functions of tearful crying. Despite an accumulating understanding of the neurobiology of human emotional crying, the primary sources of information are currently from animal studies and observations in neurologic patients suffering from pathologic crying. Currently, most of the research on the neurobiology of crying in humans has focused on autonomic physiologic processes underlying tearful crying, which may yield essential clues regarding the neural substrates of the production of crying behavior and its effects on the crier. Further challenges in elucidating the neurobiology of crying involve the complexity of crying behavior, which includes vocalizations, tear production, the involvement of facial musculature, subjective emotional experience, emotion regulatory behaviors, and social behaviors. Future research is needed to comprehensively characterize the neurobiology of this intriguing and complex human behavior.

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  1. 1.

    Gračanin A, Bylsma LM, Vingerhoets AJJM (2018) Why only humans shed emotional tears: evolutionary and cultural perspectives. Hum Nat.

    Article  PubMed  Google Scholar 

  2. 2.

    Newman JD (2007) Neural circuits underlying crying and cry responding in mammals. Behav Brain Res 182:155–165

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Vingerhoets AJJM, Bylsma LM (2016) The riddle of human emotional crying: a challenge for emotion researchers. Emot Rev 8:207–217

    Article  PubMed  Google Scholar 

  4. 4.

    Vingerhoets AJJM (2013) Why only humans weep: unravelling the mysteries of tears. Oxford University Press, Oxford

    Book  Google Scholar 

  5. 5.

    Bylsma LM, Vingerhoets AJJM, Rottenberg J (2008) When is crying cathartic? An international study. J Social Clin Psychol 27:1165–1187

    Article  Google Scholar 

  6. 6.

    Rottenberg J, Bylsma LM, Vingerhoets AJJM (2008) Is crying beneficial? Curr Dir Psychol Sci 17:400–404

    Article  Google Scholar 

  7. 7.

    Gračanin A, Vingerhoets AJJM, Kardum I, Zupčić M, Šantek M, Šimić M (2015) Why crying does and sometimes does not seem to alleviate mood: a quasi-experimental study. Motiv Emot 39:953–960

    Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Jürgens U (2009) The neural control of vocalization in mammals: a review. J Voice 23:1–10

    Article  PubMed  Google Scholar 

  9. 9.

    Morecraft RJ, Stilwell-Morecraft KS, Rossing WR (2004) The motor cortex and facial expression: new insights from neuroscience. Neurology 10:235–249

    Article  Google Scholar 

  10. 10.

    Dartt DA (2009) Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res 28:155–177

    Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Hodges RR, Dartt DA (2003) Regulatory pathways in lacrimal gland epithelium. Int Rev Cytol 231:129–196

    Article  CAS  PubMed  Google Scholar 

  12. 12.

    Van Haeringen N (2001) The (neuro)anatomy of the lacrimal system and the biological aspects of crying. In: Vingerhoets AJJM, Cornelius RR (eds) Adult crying: a biopsychosocial approach. Routledge, Hove, pp 19–36

    Google Scholar 

  13. 13.

    Benarroch EE (1993) The Central Autonomic Network: functional organization, dysfunction, and perspective. Mayo Clin Proc 68:988–1001

    Article  CAS  PubMed  Google Scholar 

  14. 14.

    Kardon R (2005) Anatomy and physiology of the autonomic nervous system. In: Miller NR, Newman NJ, Biousse V, Kerrison JB (eds) Walsh and Hoyt’s Clinical Neuro-ophthalmology, volume 1, 6th edn. Lippincott Wiliams and Wilkins, Philadelphia, pp 647–671

    Google Scholar 

  15. 15.

    Mendoza-Santiesteban CE, Palma J, Norcliffe-Kaufmann L, Kaufmann H (2017) Familial dysautonomia: a disease with hidden tears. J Neurol 264:1290–1291

    Article  PubMed  PubMed Central  Google Scholar 

  16. 16.

    Hof PR (2011) Von Economo Neurons in FD. In: 2011 International Familial Dysautonomia Research Conference, New York

  17. 17.

    Allman JM, Tetreault NA, Hakeem AY et al (2011) The von Economo neurons in the frontoinsular and anterior cingulate cortex. Ann NY Acad Sci 1225:59–71

    Article  PubMed  Google Scholar 

  18. 18.

    Seeley WW (2008) Selective functional, regional, and neuronal vulnerability in fronto-temporal dementia. Curr Opin Neurol 21:701–707

    Article  PubMed  PubMed Central  Google Scholar 

  19. 19.

    Porges SW (2001) The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol 42:123–146

    Article  CAS  PubMed  Google Scholar 

  20. 20.

    Porges SW (2007) The polyvagal perspective. Biol Psychol 74:116–143

    Article  PubMed  Google Scholar 

  21. 21.

    Ochsner KN, Gross JJ (2005) The cognitive control of emotion. Trends Cogn Sci 9:242–249

    Article  PubMed  Google Scholar 

  22. 22.

    Appelhans BM, Luecken LJ (2006) Heart rate variability as an index of regulated emotional responding. Rev Gen Psychol 10:229–240

    Article  Google Scholar 

  23. 23.

    Vasilev CA, Crowell SE, Beauchaine TP, Mead HK, Gatzke-Kopp LM (2009) Correspondence between physiological and self-report measures of emotion dysregulation: a longitudinal investigation of youth with and without psychopathology. J Child Psychol Psychiatry 50:1357–1364

    Article  PubMed  Google Scholar 

  24. 24.

    Bylsma LM, Salomon K, Taylor-Clift A, Morris BH, Rottenberg J (2014) RSA reactivity in current and remitted major depressive disorder. Psychosom Med 76:66–73

    Article  PubMed  Google Scholar 

  25. 25.

    Holzman JB, Bridgett DJ (2017) Heart rate variability indices as bio-markers of top-down self-regulatory mechanisms: a meta-analytic review. Neurosci Biobehav Rev 74:233–255

    Article  PubMed  PubMed Central  Google Scholar 

  26. 26.

    Porges SW, Lewis GF (2010) The polyvagal hypothesis: common mechanisms mediating autonomic regulation, vocalizations and listening. In: Brudzynski SM (ed) Handbook of mammalian vocalization: an integrative neuroscience approach. Elsevier, Amsterdam, pp 255–264

    Chapter  Google Scholar 

  27. 27.

    Kraemer DL, Hastrup JL (1988) Crying in adults: self-control and autonomic correlates. J Soc Clin Psychol 6:53–68

    Article  Google Scholar 

  28. 28.

    Gross JJ, Fredrickson BL, Levenson RW (1994) The psychophysiology of crying. Psychophysiology 31:460–468

    Article  CAS  PubMed  Google Scholar 

  29. 29.

    Sakuragi S, Sugiyama Y, Takeuchi K (2002) Effects of laughing and weeping on mood and heart rate variability. J Physiol Anthropol Appl Hum Sci 21:159–165

    Article  Google Scholar 

  30. 30.

    Rottenberg J, Gross JJ, Wilhelm FH, Najmi S, Gotlib IH (2002) Crying threshold and intensity in major depressive disorder. J Abnorm Psychol 111:302–312

    Article  PubMed  Google Scholar 

  31. 31.

    Rottenberg J, Wilhelm FH, Gross JJ, Gotlib IH (2003) Vagal rebound during resolution of tearful crying among depressed and nondepressed individuals. Psychophysiology 40:1–6

    Article  PubMed  Google Scholar 

  32. 32.

    Hendriks MCP, Rottenberg J, Vingerhoets AJJM (2007) Can the distress signal and arousal-reduction view be reconciled? Evidence from the cardiovascular system. Emotion 7:458–463

    Article  PubMed  Google Scholar 

  33. 33.

    Wassiliwizky E, Jacobsen T, Heinrich J, Schneiderbauer M, Menninghaus W (2017) Tears falling on goosebumps: co-occurrence of emotional lacrimation and emotional piloerection indicates a psychophysiological climax in emotional arousal. Front Psychol.

    Article  PubMed  PubMed Central  Google Scholar 

  34. 34.

    Mori K, Iwanaga M (2017) Two types of peak emotional responses to music: the psychophysiology of chills and tears. Sci Rep.

    Article  PubMed  PubMed Central  Google Scholar 

  35. 35.

    De Morree HM, Szabó BM, Rutten GJ, Kop WJ (2013) Central nervous system involvement in the autonomic responses to psychological distress. Neth Heart J 21:64–69

    Article  PubMed  Google Scholar 

  36. 36.

    Scott JP (1974) Effects of psychotropic drugs on separation distress in dogs. In Proceedings of IX Congress of the Collegium International Neuropsychopharmacologicum. Int Congr Ser–Excerpta Med 359:735–745

    Google Scholar 

  37. 37.

    Gruber-Dujardin E (2010) Role of the periaqueductal gray in expressing vocalization. In: Brudzynski SM (ed) Handbook of mammalian vocalization: an integrative neuroscience approach. Elsevier, Amsterdam, pp 313–327

    Chapter  Google Scholar 

  38. 38.

    Zhang SP, Davis PJ, Bandler R, Carrive P (1994) Brain stem integration of vocalization: the role of the midbrain periaqueductal gray. J Neurophysiol 72:1337–1356

    Article  CAS  PubMed  Google Scholar 

  39. 39.

    Jürgens U (2002) Neural pathways underlying vocal control. Neurosci Biobehav Rev 26:235–258

    Article  PubMed  Google Scholar 

  40. 40.

    Schulz GM, Varga M, Jeffires K, Ludlow CL, Braun AR (2005) Functional neuroanatomy of human vocalization: an H215O PET study. Cereb Cortex 15:1835–1847

    Article  CAS  PubMed  Google Scholar 

  41. 41.

    Panksepp J (2011) The neurobiology of social loss in animals: some keys to the puzzle of psychic pain in humans. In: Jensen-Campbell LA, MacDonald G (eds) Social pain: neuropsychological and health implications of loss and exclusion. American Psychological Association, Washington, pp 11–52

    Chapter  Google Scholar 

  42. 42.

    Posse S, Fitzgerald D, Gao K, Habel U, Rosenberg D, Moore GJ, Schneider F (2003) Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness. NeuroImage 18:760–768

    Article  PubMed  Google Scholar 

  43. 43.

    Phan KL, Wager T, Taylor SF, Liberzon I (2002) Functional neuroanatomy of emotion: a meta-analysis of emotion: activation studies in PET and fMRI. NeuroImage 16:331–348

    Article  Google Scholar 

  44. 44.

    Arciniegas DB, Lauterbach EC, Anderson KE et al (2005) The differential diagnosis of pseudobulbar affect (PBA): distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meeting. CNS Spectr 10:1–14

    Article  PubMed  Google Scholar 

  45. 45.

    Miller A, Pratt H, Schiffer RB (2011) Pseudobulbar affect: the spectrum of clinical presentations, etiologies, and treatments. Expert Rev Neurother 11:1077–1088

    Article  PubMed  Google Scholar 

  46. 46.

    Rabins PV, Arciniegas DB (2007) Pathophysiology of involuntary emotional expression disorder. CNS Spectr 12(4 suppl.):17–22

    Article  PubMed  Google Scholar 

  47. 47.

    Wortzel HS, Oster TJ, Anderson CA, Arciniegas DB (2008) Pathological laughing and crying: epidemiology, pathophysiology, and treatment. CNS Drugs 22:531–545

    Article  CAS  PubMed  Google Scholar 

  48. 48.

    Parvizi J, Coburn KL, Shillcutt SD, Coffey CE, Lauterbach EC, Mendez MF (2009) Neuroanatomy of pathological laughing and crying: a report of the American Neuropsychiatric Association Committee on Research. J Neuropsychiatry Clin Neurosci 21:75–87

    Article  PubMed  Google Scholar 

  49. 49.

    Sato-Suzuki I, Fumoto M, Seki Y et al (2007) Activation of the medial prefrontal cortex during crying with emotional tears: near-infrared spectroscopy study. Auton Neurosci 135:128–137

    Article  Google Scholar 

  50. 50.

    Znoj H (1997) When remembering the lost spouse hurts too much: first results with a newly developed observer measure for tears and crying related coping behavior. In: Vingerhoets AJJM, van Bussel FJ, Boelhouwer AJW (eds) The (non)expression of emotions in health and disease. Tilburg University Press, Tilburg, pp 337–352

    Google Scholar 

  51. 51.

    Thayer JF, Lane RD (2009) Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev 33:81–88

    Article  PubMed  Google Scholar 

  52. 52.

    Etkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85–93

    Article  Google Scholar 

  53. 53.

    Panksepp J, Meeker R, Bean NJ (1980) The neurochemical control of crying. Pharmacol Biochem Behav 12:437–443

    Article  CAS  PubMed  Google Scholar 

  54. 54.

    Panksepp J (2010) Emotional causes and consequences of social-affective vocalization. In: Brudzynski SM (ed) Handbook of mammalian vocalization: an integrative neuroscience approach. Elsevier, Amsterdam, pp 201–208

    Chapter  Google Scholar 

  55. 55.

    Harris JC, Newman JD (1987) Mediation of separation distress by α2-adrenergic mechanisms in a non-human primate. Brain Res 410:353–356

    Article  CAS  PubMed  Google Scholar 

  56. 56.

    Bowlby J (1969) Attachment. Basic Books, New York

    Google Scholar 

  57. 57.

    Nelson JK (2005) Seeing through tears: crying and attachment. Routledge, New York

    Google Scholar 

  58. 58.

    Snowdon CT, Ziegler TE (2004) Reproductive hormones. In: Cacioppo JT, Tassinary LG, Berntson GG (eds) Handbook of psychophysiology, 2nd edn. Cambridge University Press, Cambridge, pp 368–396

    Google Scholar 

  59. 59.

    Insel TR, Young LJ (2001) The neurobiology of attachment. Nat Rev Neurosci 2:129–136

    Article  CAS  Google Scholar 

  60. 60.

    Panksepp J (1998) Affective neuroscience: the foundations of human and animal emotions. Oxford University Press, New York

    Google Scholar 

  61. 61.

    Gračanin A, Bylsma LM, Vingerhoets AJJM (2014) Is crying a self-soothing behaviour? Front Psychol.

    Article  PubMed  PubMed Central  Google Scholar 

  62. 62.

    Hackett ML, Yang M, Anderson CS, Horrocks JA, House A (2010) Pharmaceutical interventions for emotionalism after stroke. Cochrane Database Syst Rev. (Art. No.: CD003690)

    Article  PubMed  Google Scholar 

  63. 63.

    Van der Veen FM, Jorritsma J, Krijger C, Vingerhoets AJJM (2012) Paroxetine reduces crying in young women watching emotional movies. Psychopharmacology 220:303–308

    Article  CAS  PubMed  Google Scholar 

  64. 64.

    Van Tilburg MAL, Unterberg M, Vingerhoets AJJM (2002) Crying during adolescence: the role of gender, menarche, and empathy. Br J Dev Psychol 20:77–87

    Article  Google Scholar 

  65. 65.

    Frey WH (1985) The mystery of tears. Winston Press, Minneapolis

    Google Scholar 

  66. 66.

    Eugster A, Horsten M, Vingerhoets AJJM (2001) Menstrual cycle, pregnancy, and crying. In: Vingerhoets AJJM, Cornelius RR (eds) Adult crying: a biopsychosocial approach. Brunner-Routledge, Hove, pp 177–198

    Google Scholar 

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The authors express their gratitude for the input of Ton van Boxtel and Kees Brunia on earlier versions of the figure. The final figure was drawn by Rogier Trompert. The authors also appreciate the feedback from two anonymous reviewers for their helpful feedback on an earlier version of this manuscript. The first author, Lauren M. Bylsma, is supported by an NIMH K01 Award (MH104325).

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Correspondence to Lauren M. Bylsma.

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Bylsma, L.M., Gračanin, A. & Vingerhoets, A.J.J.M. The neurobiology of human crying. Clin Auton Res 29, 63–73 (2019).

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  • Crying
  • Tears
  • Social
  • Emotion
  • Neurobiology
  • Physiology