Abstract
Purpose
To determine if autonomic symptoms are associated with previous Zika virus infection.
Methods
Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31).
Results
Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001).
Conclusion
Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.
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Acknowledgements
The authors would like to thank the people who participated in this study and Hermelinda Rueda, Julián Barahona-Correa, Nicolás Molano-González, Cecile Dunn and all the members of the Center for Autoimmune Diseases Research (CREA) for their contributions. A special thanks is also extended to Dr. Eduardo E. Benarroch, from the Mayo Clinic Rochester, for his fruitful discussions, which helped us to improve the manuscript. Finally, we thank the reviewers of this manuscript for their careful reading and their many insightful comments and suggestions.
Funding
This study was supported by Universidad del Rosario (ABN011), and Colciencias (747-2016), Bogotá, Colombia.
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JMA and YR conceived and planned the study. YR travelled to Cucuta, contacted the patients and applied the COMPASS-31. YAA, DMM and CRS performed the neutralizing antibody and plaque reduction neutralization tests. YR and MR led the linguistic validation of COMPASS-31. YR, MR, CRS, YAA, DMM and JMA contributed to the interpretation of the results. YR, MR, and JMA drafted the manuscript. All authors provided critical feedback and helped shape the research, analysis and manuscript.
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Rodríguez, Y., Rojas, M., Ramírez-Santana, C. et al. Autonomic symptoms following Zika virus infection. Clin Auton Res 28, 211–214 (2018). https://doi.org/10.1007/s10286-018-0515-1
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DOI: https://doi.org/10.1007/s10286-018-0515-1