Clinical Autonomic Research

, Volume 28, Issue 2, pp 203–209 | Cite as

Cyclic vomiting syndrome: epidemiology, diagnosis, and treatment

  • Sanjay BhandariEmail author
  • Pinky Jha
  • Abhishek Thakur
  • Abhipsa Kar
  • Harrison Gerdes
  • Thangam Venkatesan


Cyclic-vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder characterized by recurrent episodes of nausea and vomiting. Although once thought to be a pediatric disorder, there has been a considerable increase in recognition of CVS in adults. The exact pathogenesis is unknown and several theories have been proposed. Migraine and CVS share a similar pathophysiology as suggested by several studies. Since there are no specific biomarkers available for this disorder, physicians should rely on Rome criteria for the diagnosis. Due to the lack of randomized control trials, the treatment of CVS is primarily empirical.




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Conflicts of interest



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of General Internal MedicineMedical College of WisconsinMilwaukeeUSA
  2. 2.Quinnipiac University Frank H. Netter MD School of MedicineNorth HavenUSA
  3. 3.Medical College of WisconsinWisconsinUSA
  4. 4.Division of Gastroenterology and HepatologyMedical College of WisconsinMilwaukeeUSA
  5. 5.Division of General Internal Medicine, Clinical Cancer CenterMedical College of WisconsinMilwaukeeUSA

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