Sympathetic neurograms showing characteristics of both muscle and skin sympathetic nerve activity in a case with pure autonomic failure
We present sympathetic burst discharges that showed characteristics of both muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA) recorded in a case of pure autonomic failure (PAF).
In September 2003, a 69-year-old man was admitted to our hospital because of frequent syncope and orthostatic dizziness for a year. On examination, he had a clear consciousness and normal cortical function (MMSE score of 29). Examination of the autonomic nervous system revealed significant orthostatic hypotension (OH). His supine BP was 142/86 mmHg (pulse rate was 73/min), and it decreased to 92/66 mmHg (pulse rate of 71/min) after standing for 3 min. He complained of decreased sweating on the face and trunk during summer for the last 3 years. He also complained of constipation and pollakiuria. Other neurological examinations revealed no abnormalities.
Laboratory tests showed that the complete blood count, biochemical profile, electrocardiography (ECG), and...
KeywordsPure autonomic failure Muscle sympathetic nerve activity Skin sympathetic nerve activity Electrical stimulation Reflex latency
Pure autonomic failure
Muscle sympathetic nerve activity
Skin sympathetic nerve activity
Sympathetic skin response
Skin vasomotor reflex
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Conflict of interest
The authors confirm that there is no conflict of interest.