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Clinical Autonomic Research

, Volume 28, Issue 3, pp 347–349 | Cite as

Sympathetic neurograms showing characteristics of both muscle and skin sympathetic nerve activity in a case with pure autonomic failure

  • Kazumasa Shindo
  • Akane Satake
  • Naofumi Kurita
  • Toko Sato
  • Mai Tsuchiya
  • Yuta Ichinose
  • Takanori Hata
  • Kishin Koh
  • Takamura Nagasaka
  • Yoshihisa Takiyama
Letter to the Editor

Dear Editors,

We present sympathetic burst discharges that showed characteristics of both muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA) recorded in a case of pure autonomic failure (PAF).

In September 2003, a 69-year-old man was admitted to our hospital because of frequent syncope and orthostatic dizziness for a year. On examination, he had a clear consciousness and normal cortical function (MMSE score of 29). Examination of the autonomic nervous system revealed significant orthostatic hypotension (OH). His supine BP was 142/86 mmHg (pulse rate was 73/min), and it decreased to 92/66 mmHg (pulse rate of 71/min) after standing for 3 min. He complained of decreased sweating on the face and trunk during summer for the last 3 years. He also complained of constipation and pollakiuria. Other neurological examinations revealed no abnormalities.

Laboratory tests showed that the complete blood count, biochemical profile, electrocardiography (ECG), and...

Keywords

Pure autonomic failure Muscle sympathetic nerve activity Skin sympathetic nerve activity Electrical stimulation Reflex latency 

Abbreviations

PAF

Pure autonomic failure

MSNA

Muscle sympathetic nerve activity

SSNA

Skin sympathetic nerve activity

HR

Heart rate

BP

Blood pressure

ECG

Electrocardiography

SSR

Sympathetic skin response

SVR

Skin vasomotor reflex

ES

Electrical stimulation

RL

Reflex latency

Notes

Funding

There was no funding of this research.

Compliance with ethical standards

Conflict of interest

The authors confirm that there is no conflict of interest.

Supplementary material

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Supplementary material 1 (TIFF 1521 kb): Fig. 2. Histograms of reflex latencies from the prior R wave on the electrocardiogram to the peak in bursts of spontaneous and reflex discharges
10286_2017_497_MOESM2_ESM.tiff (1.5 mb)
Supplementary material 2 (TIFF 1521 kb): Fig. 3. Histograms of reflex latencies from electrical stimuli to the initiation of and peak in reflex bursts
10286_2017_497_MOESM3_ESM.tiff (1.5 mb)
Supplementary material 3 (TIFF 1521 kb). Fig. 4. Histograms of R–R on the electrocardiogram and burst–burst intervals on neurograms
10286_2017_497_MOESM4_ESM.docx (129 kb)
Supplementary material 4 (DOCX 128 kb): Detailed methods of this study
10286_2017_497_MOESM5_ESM.docx (81 kb)
Supplementary material 5 (DOCX 81 kb): Table 1. The quantitative data measured in this study

References

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    Donadio V, Cortelli P, Elam M, Di Stasi V, Montagna P, Holmberg B (2010) Autonomic innervation in multiple system atrophy and pure autonomic failure. J Neurol Neurosurg Psychiatry 81:1327–1335CrossRefPubMedGoogle Scholar
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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Kazumasa Shindo
    • 1
  • Akane Satake
    • 1
  • Naofumi Kurita
    • 1
  • Toko Sato
    • 1
  • Mai Tsuchiya
    • 1
  • Yuta Ichinose
    • 1
  • Takanori Hata
    • 1
  • Kishin Koh
    • 1
  • Takamura Nagasaka
    • 1
  • Yoshihisa Takiyama
    • 1
  1. 1.Department of NeurologyUniversity of YamanashiChuoJapan

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