Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study

Abstract

Purpose

Electronic cigarettes are growing in popularity, but the physiological consequences of vaporized nicotine are unknown.

Methods

Twenty healthy non-smokers inhaled vaporized nicotine and placebo (randomized).

Results

Nicotine inhalation was associated with higher arterial pressures in the seated position, and increased arterial pressures in the head-up positions with no other effects on autonomic control.

Conclusions

Our results show that vaporized nicotine inhalation is not innocuous. Longitudinal studies in otherwise healthy non-smokers should be conducted.

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Acknowledgments

This study was supported by a Collaborative Seed Grant through the Office of the Vice President for Research, University of Texas at San Antonio, San Antonio Texas. We appreciate the technical assistance of Ms. Audrey Ramirez.

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Correspondence to William H. Cooke.

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The authors declare that they have no conflict of interest.

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Cooke, W.H., Pokhrel, A., Dowling, C. et al. Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study. Clin Auton Res 25, 267–270 (2015). https://doi.org/10.1007/s10286-015-0304-z

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Keywords

  • Electronic cigarettes
  • Head-up tilt
  • Blood pressure
  • Autonomic control