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Holmes-Adie syndrome associated with high altitude pulmonary edema and low chemo-responsiveness to hypoxia

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Abstract

A 63-year-old patient with Holmes-Adie syndrome presented an altered peripheral chemoreflex and suffered from high altitude pulmonary edema, suggesting an alteration of sensitive afferent fibers from the peripheral chemoreceptors. Chemo-responsiveness to hypoxia should be explored before any exposure to moderate altitude in Holmes-Adie patients.

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References

  1. Richalet JP, Gimenez-Roqueplo AP, Peyrard S, Vénisse A, Marelle L, Burnichon N, Bouzamondo A, Jeunemaitre X, Azizi M, Elghozi JL (2009) A role for succinate dehydrogenase genes in low chemoresponsiveness to hypoxia? Clin Auton Res 19:335–342

    Article  PubMed  Google Scholar 

  2. Maggiorini M (2006) High altitude-induced pulmonary oedema. Cardiovasc Res 72:41–50

    Article  CAS  PubMed  Google Scholar 

  3. Bacon PJ, Smith SE (1993) Cardiovascular and sweating dysfunction in patients with Holmes-Adie syndrome. J Neurol Neurosurg Psychiatry 56:1096–1102

    Article  CAS  PubMed  Google Scholar 

  4. Martinelli P (2000) Holmes-Adie syndrome. Lancet 356:1760–1761

    Article  CAS  PubMed  Google Scholar 

  5. Ford PA, Barnes PJ, Usmani OS (2007) Holmes-Adie syndrome chronic cough. Lancet 369:342

    Article  PubMed  Google Scholar 

  6. Bernardi L, Hilz M, Stemper B, Passino C, Welsch G, Axelrod FB (2003) Respiratory and cerebrovascular responses to hypoxia and hypercapnia in familial dysautonomia. Am J Respir Crit Care Med 167:141–149

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Service de Physiologie, Explorations Fonctionnelles et Médecine du Sport, AP-HP, Hôpital Avicenne, 93009, Bobigny, France

    Jean-Paul Richalet & Murielle Letournel

  2. Laboratoire « Réponses Cellulaires et Fonctionnelles à l’Hypoxie », EA2363, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny, France

    Jean-Paul Richalet

  3. Service de Neurologie, AP-HP, Hôpital Avicenne, 93009, Bobigny, France

    Jeffrey Salama

Authors
  1. Jean-Paul Richalet
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  2. Murielle Letournel
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  3. Jeffrey Salama
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Correspondence to Jean-Paul Richalet.

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Richalet, JP., Letournel, M. & Salama, J. Holmes-Adie syndrome associated with high altitude pulmonary edema and low chemo-responsiveness to hypoxia. Clin Auton Res 21, 55–56 (2011). https://doi.org/10.1007/s10286-010-0081-7

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  • DOI: https://doi.org/10.1007/s10286-010-0081-7

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