Abstract
In order to evaluate gastric motility and its circadian rhythm in patients with multiple system atrophy (MSA) and healthy control subjects, we measured gastric myoelectrical activity (GMA) for 24 hours using a cutaneous electrogastrogram (EGG) recorder in 14 MSA patients and 9 age-matched controls.We analyzed six 10-minute segments of EGG before and after each meal and two 20-minute EGG segments during sleep; three parameters were used for the analysis: dominant frequency (DF), instability coefficient of dominant frequency (ICDF), and dominant power (DP). DF increased during daytime and decreased during sleep in the control, while this circadian variation was blunted in the patients with MSA. The average DF of the eight segments in the MSA patients did not differ from that of the control. Both MSA patients and control subjects did not show the circadian variation of ICDF and DP. The average ICDF of the eight segments in the patients with MSA was significantly decreased when compared with that of the control (p<0.01). No differences were observed in DP between the two groups. This study indicates that the healthy subjects appear to have a circadian rhythm of DF, and the patients with MSA appear to have impaired circadian rhythm of DF and decreased ICDF possibly due to the degeneration of the central autonomic neurons.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berkowits DM, McCallum RW (1980) Interaction of levodopa and metochlopramide on gastric emptying. Clin Pharmacol Ther 27:414–420
Chen JD, Liang J, Pan J, Sutphen J, Torres-Pinedo RB (1997) Patterns of gastric myoelectrical activity in human subjects of different ages. Am J Physiol 272:G1022–G1027
Chen JDZ, Lin Z, Pan J, McCallum RW (1996) Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis. Dig Dis Sci 41:1538–1545
Chen JD, McCallum RW (1994) Electrogastrographic parameters and their clinical significance. In: Chen JD, McCallum RW (eds) Electrogastrography: Principles and applications. Raven Press,New York, pp 45–73
Elsenbruch S, Orr WC, Harnish MJ, Chen JDZ (1999) Disruption of normal gastric myoelectric functioning by sleep. Sleep 22:453–458
Hamilton JW, Bellahsene BE, Reicherlderfer M, Webster JG, Bass P (1986) Human electrogastrograms. Comparison of surface and mucosal recordings. Dig Dis Sci 31:33–39
Koch KL (2001) Electrogastrography: physiological basis and clinical application in diabetic gastropathy. Diabetes Technol Ther 3:51–62
Kohagen KR, Kim MS, McDonnel WM, Chey WD, Owyang C, Hasler WL (1996) Nicotine effects on prostaglandin-dependent gastric slow wave rhythmicity and antral motility in nonsmokers and smokers. Gastroenterol 110:3–11
Lantos PL (1997) Multiple system atrophy. Brain Pathology 7:1293–1297
Levanon D, Zhang M, Chen JD (1998) Efficiency and efficacy of the electrogastrogram. Dig Dis Sci 43:1023–1030
Liang JIE, Chen JDZ (1997) What can be measured from surface electrogastrography: computer stimulations. Dig Dis Sci 42:1331–1343
Lindberg G, Iwarzon M, Hammarlund B (1996) 24-hour ambulatory electrogastrography in healthy volunteers. Scand J Gastroenterol 31:658–664
Lu CL, Sshan DE, Chen CY, Luo JC, Chang FY, Lee SD, Wu HC, Chen JD (2004) Impaired gastric myoelectrical activity in patients with Parkinson’s disease and effect of levodopa treatment. Dig Dis Sci 49:744–749
Lu CL, Shidler N, Chen JD (2000) Enhanced postprandial gastric myoelectrical activity after moderateintensity exercise. Am J Gastroenterol 95:425–431
Lu CL,Montgomery P, Zou X, Orr WC, Chen JDZ (1998) Gastric myoelectrical activity in patients with cervical spinal cord injury. Am J Gastroenterol 93:2391–2396
Muth ER, Thayer JF, Stern RM, Friedman B, Drake C (1998) The effect of autonomic nervous system activity on gastric myoelectrical activity: does the spectral reserve hypothesis hold for the stomach? Biol Psychol 47:265–278
Orr WC, Crowell MD, Lin B, Harnish MJ, Chen JD (1997) Sleep and gastric function in irritable bowel syndrome: derailing the brain-gut axis. Gut 41:390–393
Quinn N (1996) Multiple system atrophy. In: Marsden CD, Fahn S (eds) Movement disorders 3. Butterworths, London, pp 262–281
Sanmiguel CP, Mintchev MP, Bowes KL (1998) Electrogastrography: A noninvasive technique to evaluate gastric electrical activity. Can J Gastroenterol 12:423–430
Smout AJPM, Jebbink HJA, Samsom M (1994) Acquisition and analysis of electrogastrographic data—the Dutch experience. In: Chen JD, McCallum RW (eds) Electrogastrography: Principles and applications. Raven Press, New York, pp 3–3
Smout AJ, van der Schee EJ, Grashuis JL (1980) What is measured in electrogastrography? Dig Dis Sci 25:179–187
Takahashi T, Kurosawa S, Wiley J, Owyang C (1991) Mechanism for the gastrokinetic action of domperidone. Gastroenterol 101:703–710
Van Nueten JM, Shuurkes AJ (1984) Studies on the role of dopamine and dopamine blockers in gastroduodenal motility. Scand J Gastroenterol (Suppl) 96:89–99
Verhagen M, van Schelven L, Samsom M, Smout A (1999) Pitfalls in the analysis of electrogastrographic recordings. Gastroenterol 117:453–460
Weber J, Kohatsu S (1970) Pacemaker localization and electrical conduction patterns in the canine stomach. Gastroenterol 59:717–726
Wingate DL (1999) Autonomic function and dysfunction in the gastrointestinal tract. In: Mathias CJ, Bannister R (eds) Autonomic failure. A textbook of clinical disorder of the autonomic nervous system.Oxford University Press, Oxford, pp 271–282
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Suzuki, A., Asahina, M., Ishikawa, C. et al. Impaired circadian rhythm of gastric myoelectrical activity in patients with multiple system atrophy. Clin Auton Res 15, 368–372 (2005). https://doi.org/10.1007/s10286-005-0294-3
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10286-005-0294-3