Skip to main content

Pyridostigmine for treatment of neurogenic orthostatic hypertension

A follow-up survey study

Abstract

We report the result of a follow-up, open-label study of pyridostigmine for treatment of orthostatic hypotension. Aim of the study was to evaluate self-reported efficacy and patients’ satisfaction with the medication. Most patients were very satisfied with the medication and chose to continue it.

This is a preview of subscription content, access via your institution.

References

  1. Camilleri M, Malagelada JR, Stanghellini V, Fealey RD, Sheps SG (1985) Gastrointestinal motility disturbances in patients with orthostatic hypotension. Gastroenterology 88(6):1852–1859

    CAS  PubMed  Google Scholar 

  2. Chobadian AV, Volicer L, Tifft CP, Gavras H, Liang CS, Faxon D (1979) Mineralocorticoid-induced hypertension in patients with orthostatic hypotension. N Engl J Med 301(2):68–73

    Article  Google Scholar 

  3. Consensus statement (1996) The definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin Auton Res 519:1–10

    Google Scholar 

  4. Goldstein DS, Pechnik S, Holmes C, Eldadah B, Sharabi Y (2003) Association between supine hypertension and orthostatic hypotension in autonomic failure [erratum appears in Hypertension (2003) 43(4):e12]. Hypertension 42(2):136–142

    CAS  PubMed  Google Scholar 

  5. Jacob G, Shannon JR, Black B, et al. (1997) Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia. Circulation 96(2):575–580

    CAS  PubMed  Google Scholar 

  6. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA (1997) Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group [erratum appears in JAMA (1997) 278(5):388]. JAMA 277(13):1046–1051

    Article  CAS  PubMed  Google Scholar 

  7. Shannon J, Jordan J, Costa F, Robertson RM, Biaggioni I, Robertson D, Biaggioni I (1997) The hypertension of autonomic failure and its treatment. Hypertension 30(5):1062–1067

    CAS  PubMed  Google Scholar 

  8. Singer W, Opfer-Gehrking TL, McPhee BR, Hilz MJ, Bharucha AE, Low PA (2003) Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension [see comment]. J Neurol Neurosurg Psychiatry 74(9):1294–1298

    CAS  PubMed  Google Scholar 

  9. Wieling W, van Lieshout JJ (1997) Maintenance of postural normotension in humans. In: Low PA (ed.) Clinical autonomic disorders: evaluation and management. 2nd ed. Philadelphia. Lippincott-Raven, pp 73–82

  10. Wright RA, Kaufmann HC, Perera R, Opfer-Gehrking TL, McElligott MA, Sheng KN, Low PA (1998) A doubleblind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology 51(1):120–124

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paola Sandroni.

Additional information

This study was supported in part from grants from the National Institutes of Health, Bethesda, MD: 5 K23 RR15537 (Dr. Sandroni), NS3 2352, NS4 4233 NS4 3364 (Dr. Low), and Mayo GCRC grant M01-RR00585

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sandroni, P., Opfer-Gehrking, T.L., Singer, W. et al. Pyridostigmine for treatment of neurogenic orthostatic hypertension. Clin Auton Res 15, 51–53 (2005). https://doi.org/10.1007/s10286-005-0225-3

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10286-005-0225-3

Key words

  • orthostatic hypotension
  • pyridostigmine