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Prior to Initiation of Chemotherapy, Can We Predict Breast Tumor Response? Deep Learning Convolutional Neural Networks Approach Using a Breast MRI Tumor Dataset

  • Richard HaEmail author
  • Christine Chin
  • Jenika Karcich
  • Michael Z. Liu
  • Peter Chang
  • Simukayi Mutasa
  • Eduardo Pascual Van Sant
  • Ralph T. Wynn
  • Eileen Connolly
  • Sachin Jambawalikar
Article

Abstract

We hypothesize that convolutional neural networks (CNN) can be used to predict neoadjuvant chemotherapy (NAC) response using a breast MRI tumor dataset prior to initiation of chemotherapy. An institutional review board-approved retrospective review of our database from January 2009 to June 2016 identified 141 locally advanced breast cancer patients who (1) underwent breast MRI prior to the initiation of NAC, (2) successfully completed adriamycin/taxane-based NAC, and (3) underwent surgical resection with available final surgical pathology data. Patients were classified into three groups based on their NAC response confirmed on final surgical pathology: complete (group 1), partial (group 2), and no response/progression (group 3). A total of 3107 volumetric slices of 141 tumors were evaluated. Breast tumor was identified on first T1 postcontrast dynamic images and underwent 3D segmentation. CNN consisted of ten convolutional layers, four max-pooling layers, and dropout of 50% after a fully connected layer. Dropout, augmentation, and L2 regularization were implemented to prevent overfitting of data. Non-linear functions were modeled by a rectified linear unit (ReLU). Batch normalization was used between the convolutional and ReLU layers to limit drift of layer activations during training. A three-class neoadjuvant prediction model was evaluated (group 1, group 2, or group 3). The CNN achieved an overall accuracy of 88% in three-class prediction of neoadjuvant treatment response. Three-class prediction discriminating one group from the other two was analyzed. Group 1 had a specificity of 95.1% ± 3.1%, sensitivity of 73.9% ± 4.5%, and accuracy of 87.7% ± 0.6%. Group 2 (partial response) had a specificity of 91.6% ± 1.3%, sensitivity of 82.4% ± 2.7%, and accuracy of 87.7% ± 0.6%. Group 3 (no response/progression) had a specificity of 93.4% ± 2.9%, sensitivity of 76.8% ± 5.7%, and accuracy of 87.8% ± 0.6%. It is feasible for current deep CNN architectures to be trained to predict NAC treatment response using a breast MRI dataset obtained prior to initiation of chemotherapy. Larger dataset will likely improve our prediction model.

Keywords

Breast MRI Chemotherapy treatment response Convolutional neural network 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Society for Imaging Informatics in Medicine 2018

Authors and Affiliations

  • Richard Ha
    • 1
    Email author
  • Christine Chin
    • 2
  • Jenika Karcich
    • 1
  • Michael Z. Liu
    • 3
  • Peter Chang
    • 4
  • Simukayi Mutasa
    • 1
  • Eduardo Pascual Van Sant
    • 1
  • Ralph T. Wynn
    • 1
  • Eileen Connolly
    • 2
  • Sachin Jambawalikar
    • 3
  1. 1.Department of RadiologyColumbia University Irving Medical CenterNew YorkUSA
  2. 2.Division of Radiation OncologyColumbia University Medical CenterNew YorkUSA
  3. 3.Department of Medical PhysicsColumbia University Medical CenterNew YorkUSA
  4. 4.Department of RadiologyUC San Francisco Medical CenterSan FranciscoUSA

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