Skip to main content
SpringerLink
Log in

Caractérisation des tumeurs neuroendocrines digestives ou thoraciques

Characterisation of gastrointestinal and thoracic neuroendocrine tumours

  • Review Article
  • Synthèse
  • Published:
Oncologie

Abstract

Once the diagnosis of a neuroendocrine tumour has been made, characterisation is an essential step before therapy. It comes before the decision regarding treatment is made. This requires a multidisciplinary team of experts located in specialist centres that currently make up the RENATEN and TENPATH networks. It is directed by knowledge of the location of the primary tumour and anatomical pathological differentiation. The aim of this characterisation step is to highlight factors that may have an impact on the diagnosis and the prognosis or predict the response to treatment.

Résumé

Une fois le diagnostic de tumeur neuroendocrine (TNE) posé, la caractérisation est une étape essentielle de la prise en charge d’une TNE. Elle précède la décision thérapeutique. Celle-ci fait appel à une expertise multidisciplinaire au sein des centres experts actuellement regroupés au sein des réseaux RENATEN et TENpath. Elle est orientée par la connaissance de la localisation du primitif et la différenciation anatomopathologique. Cette étape de caractérisation a comme objectif: la mise en évidence de facteurs à impact diagnostique, pronostique ou prédictif de la réponse thérapeutique.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Références

  1. Baudin E, Bidart JM, Bachelot A, et al (2001) Impact of chromogranin A measurement in the work-up of neuroendocrine tumors. Ann Oncol 12(Suppl 2): S79–S82

    Article  PubMed  Google Scholar 

  2. Durante C, Boukheris H, Dromain C, et al (2009) Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well differentiated endocrine carcinoma. Endocr Relat Cancer 16(2): 585–597

    Article  PubMed  Google Scholar 

  3. Jensen RT, Cadiot G, Brandi ML, et al (2012) ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes. Neuroendocrinology 95: 98–119

    Article  CAS  PubMed  Google Scholar 

  4. Kloppel G, Rindi G, Perren A, et al (2010) The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement. Virchows Arch 456: 595–597

    Article  PubMed  Google Scholar 

  5. Kwekkeboom DJ, de Herder WW, van Eijck CH, et al (2010) Peptide receptor radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors. Semin Nucl Med 40: 78–88

    Article  PubMed  Google Scholar 

  6. Madeira I, Terris B, Voss M, et al (1998) Prognostic factors in patients with endocrine tumours of the duodenopancreatic area. Gut 43: 422–427

    Article  CAS  PubMed  Google Scholar 

  7. Mitry E, Baudin E, Ducreux M, et al (1999) Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin. Br J Cancer 81: 1351–1355

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Pavel M, Baudin E, Couvelard A, et al (2012) ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 95: 157–176

    Article  CAS  PubMed  Google Scholar 

  9. Rindi GKD, Arnold R, Klöppel G, et al (2010) Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours of the digestive system. IARC, Lyon, pp. 13–14

    Google Scholar 

  10. Scarpa A, Mantovani W, Capelli P, et al (2010) Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients. Mod Pathol: An Official Journal of the United States and Canadian Academy of Pathology, Inc 23: 824–833. (doi:10.1038/modpathol.2010.58)

    Article  CAS  Google Scholar 

  11. Scoazec JY, Couvelard A; pour le réseau TENpath (réseau national d’expertise pour le diagnostic anatomopathologique des tumeurs neuroendocrines malignes de l’adulte, sporadiques et familiales) (2011) The new WHO classification of digestive neuroendocrine tumors. Ann Pathol 31: 88–92

    Article  PubMed  Google Scholar 

  12. Sobin LHGM, Wittekind C (2009) TNM Classification of malignant tumours. 7th Edition. Wiley, New York

    Google Scholar 

  13. Thakker RV, Newey PJ, Walls GV, et al (2012) Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J Clin Endocrinol Metab 97: 2990–3011

    Article  CAS  PubMed  Google Scholar 

  14. Thésaurus national de cancérologie digestive de la Société nationale française de gastroentérologie. Chapitre 11. Tumeurs endocrines digestives. Site http://www.tncd.org/. Mise à jour 2011

  15. Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC (2004) World Health Organization Classification of Tumors. Pathology and genetics of tumors of the lung, pleura, thymus and heart. International Agency for Research on Cancer International Agency for Research on Cancer (IARC) Press, Lyon

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre expert RENATEN des tumeurs neuroendocrines, Gustave-Roussy, F-94805, Villejuif Cedex, France

    E. Baudin, J. -Y. Scoazec, C. Caramella, S. Leboulleux, O. Caron, D. Deandreis, P. Duvillard, J. Lumbroso, T. de Baere, F. Deschamps, D. Goere, F. Dumont, D. Elias, D. Malka, V. Boige, M. Schlumberger, J. Guigay, D. Planchard & M. Ducreux

Authors
  1. E. Baudin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. -Y. Scoazec
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Caramella
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Leboulleux
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. Caron
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. Deandreis
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P. Duvillard
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. Lumbroso
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. T. de Baere
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. F. Deschamps
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. D. Goere
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. F. Dumont
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. D. Elias
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. D. Malka
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. V. Boige
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. M. Schlumberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. J. Guigay
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. D. Planchard
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. M. Ducreux
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. Baudin.

Additional information

pour le comité multidisciplinaire des tumeurs neuroendocrines

About this article

Cite this article

Baudin, E., Scoazec, J.Y., Caramella, C. et al. Caractérisation des tumeurs neuroendocrines digestives ou thoraciques. Oncologie 15, 505–509 (2013). https://doi.org/10.1007/s10269-013-2343-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10269-013-2343-1

Keywords

Mots clés

Search

Navigation