Skip to main content
SpringerLink
Log in

Bilan préthérapeutique des cancers de la jonction oesogastrique

Pretreatment assessment for gastroesophageal junction cancer

  • Dossier / Thematic file
  • Published:
Oncologie

Abstract

Pretreatment assessment in patients with cancer of the gastroesophageal junction involves the evaluation of physiological status and tumor stage. Nutritional status is a prognostic and predictor factor of response to treatment; assessment involves the calculation of weight loss and the determination of serum albumin. Renal, cardiac, and pulmonary functions are evaluated (urea, creatinine, calculation of clearance, liver function tests, electrocardiogram, pulmonary function). The performance status (Karnofsky or WHO) is an important prognostic factor. The assessment of tumor stage involves the digestive endoscopy and endoscopic ultrasonography, CT thoraco-abdomino-pelvic injection, and PET-FDG. Laparoscopy is performed only when peritoneal involvement is suspected.

Résumé

Le bilan préthérapeutique d’un patient porteur d’un cancer de la jonction oesogastrique comporte l’évaluation de son état physiologique et une estimation du stade tumoral. L’état nutritionnel est un facteur pronostique et prédictif de réponse au traitement, son évaluation associe le calcul de la perte de poids et le dosage de l’albumine sérique. En l’absence d’antécédent particulier, les fonctions rénale, cardiaque et respiratoire sont évaluées de manière simple (urée, créatinine, calcul de la clairance, bilan hépatique, électrocardiogramme, exploration fonctionnelle respiratoire [EFR]). L’index d’activité quotidienne (Karnofsky ou OMS) est un important facteur pronostique. L’évaluation du stade tumoral associe l’endoscopie et l’échoendoscopie (EE) digestive, la tomodensitométrie (TDM) thoracoabdominopelvienne avec injection, la tomographie à émission de positron (PET) au 18fluorodéoxyglucose (FDG) et, en cas de doute d’envahissement péritonéal, la laparoscopie.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Références

  1. Bartels H, Stein HJ, Siewert JR (1998) Preoperative risk analysis and postoperative mortality of oesophagectomy for resectable oesophageal cancer. Br J Surg 85: 840–844

    Article  PubMed  CAS  Google Scholar 

  2. Bhutani MS, Barde CJ, Markert RJ, et al. (2002) Length of esophageal cancer and degree of luminal stenosis during upper endoscopy predict T stage by endoscopic ultrasound. Endoscopy 34: 461–463

    Article  PubMed  CAS  Google Scholar 

  3. Bollschweiler E, Schröder W, Hölscher AH, et al. (2000) Preoperative risk analysis in patients with adenocarcinoma or squamous cell carcinoma of the oesophagus. Br J Surg 87: 1106–1110

    Article  PubMed  CAS  Google Scholar 

  4. Bosch DJ, Pultrum BB, de Bock GH, et al. (2011) Comparison of different riskadjustment models in assessing shortterm surgical outcome after transthoracic esophagectomy in patients with esophageal cancer. Am J Surg 202: 303–309

    Article  PubMed  Google Scholar 

  5. Burbidge S, Mahady K, Naik K (2012) The role of CT and staging laparoscopy in the staging of gastric cancer. Clinical radiology 68(3): 251–255 (http://dx.xoi.org/10.1016/j.crad.2012.07.015)

    Article  PubMed  Google Scholar 

  6. Chen CY, Hsu JS, Wu DC, et al. (2007) Gastric cancer: preoperative local staging with 3D multi-detector row CT-correlation with surgical and histological results. Radiology 242: 472–482

    Article  PubMed  Google Scholar 

  7. de Graaf GW, Ayantunde AA, Parsons SL, et al. (2007) The role of staging laparoscopy in oesophagogastric cancers. EJSO 33: 988–992

    Article  PubMed  Google Scholar 

  8. Deans DA, Wigmore SJ, de Beaux AC, et al. (2007) Clinical prognostic scoring to aid decision-making in gastro-oesophageal cancer. Br J Surg 94: 1501–1508

    Article  PubMed  CAS  Google Scholar 

  9. Di Fiore F, Lecleire S, Pop D, et al. (2007) Baseline nutritional status is predictive of response to treatment and survival in patients treated by definitive chemoradiotherapy for a locally advanced esophageal cancer. Am J Gastroenterol 102: 2557–2563

    Article  PubMed  Google Scholar 

  10. Enzinger PC, Mayer RJ (2003) Esophageal cancer. N Engl J Med 349: 2241–2252

    Article  PubMed  CAS  Google Scholar 

  11. Flamen P, Lerut A, Van Cutsem E, et al. (2000) Utility of positron emission tomography for the staging of patients with potentially operable esophageal carcinoma. J Clin Oncol 18: 3202–3210

    PubMed  CAS  Google Scholar 

  12. Grotenhuis BJ, Wijnhoven BPL, Poley JW, et al. (2012) Preoperative assessment of tumor location and stationspecific lymph node status in patients with adenocarcinoma of the gastroesophageal junction. World J Surg 37(1): 147–155 (doi:10.1007/s00268-012-1804-9)

    Article  Google Scholar 

  13. Ikeda M, Nastugoe S, Ueno S, et al. (2003) Significant host- and tumorrelated factors for predicting prognosis in patients with esophageal carcinoma. Ann Surg 328: 197–202

    Google Scholar 

  14. Jiang X, Hiki N, Nunobe S, et al. (2012) Prognostic importance of the inflammation-based Glasgow prognostic score in patients with gastric cancer. Br J Cancer 107: 275–279

    Article  PubMed  CAS  Google Scholar 

  15. Kato H, Nakajima M (2012) The efficacy of FDG-PET for the management of esophageal cancer: review article. Ann Thorac Cardiovasc Surg 18: 412–419

    Article  PubMed  Google Scholar 

  16. Kole AC, Plukker JT, Nieweg OE, et al. (1998) Positron emission tomography for staging of oesophageal and gastroesophageal malignancy. Br J Cancer 78: 521–527

    Article  PubMed  CAS  Google Scholar 

  17. Leitch EF, Chakrabarti M, Crozier JE, et al. (2007) Comparison of the prognostic value of selectedmarkers of the systemic inflammatory response in patients with-colorectal cancer. Br J Cancer 97: 1266–1270

    Article  PubMed  CAS  Google Scholar 

  18. McMillan DC (2012) The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Cancer Treat Rev pii: S0305-7372(12)00171-5

    Google Scholar 

  19. O’Dwyer PJ, Johnson SW, Hamilton TC (1997) Cisplatin and its analogues. In: Devita VT, Hellman S (eds) Cancer, principles and practice of oncology 5th ed. Ed Lippincott-Raven, Rosenberg, pp. 418–431

    Google Scholar 

  20. Puli SR, Reddy JBK, Bechtold ML, et al. (2008) How good is endoscopic ultrasound for TNBM staging of gastric cancer? A meta-anlysis and systematic review. World J Gastroenterol 14: 4011–4019

    Article  PubMed  Google Scholar 

  21. Puli SR, Reddy JBK, Bechtold ML, et al. (2008) Staging accuracy of esophageal cancer by endoscopic ultrasound: a meta-anlysis and systematic review. World J Gastroenterol 14: 1479–1490

    Article  PubMed  Google Scholar 

  22. Sanz L, Ovejero VJ, Gonzalez JJ, et al. (2006) Mortality risk scales in esophagectomy for cancer: their usefulness in preoperative patient selection. Hepatogastroenterology 53: 869–873

    PubMed  Google Scholar 

  23. Siewert JR, Stein HJ (1998) Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg 85: 1457–1459

    Article  PubMed  CAS  Google Scholar 

  24. Smyth E, Schöder H, Strong VE, et al. (2012) A prospective evaluation of the utility of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and computed tomography in staging locally advanced gastric cancer. Cancer 118: 5481–5488

    Article  PubMed  Google Scholar 

  25. Soubeyran P, Fonck M, Blanc-Bisson C, et al. (2012) Predictors of early death risk in older patients treated with first-line chemotherapy for cancer. J Clin Oncol 30: 1829–1834

    Article  PubMed  Google Scholar 

  26. Thosani N, Singh H, Kapadia A, et al. (2012) Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and metaanalysis. Gastrointest Endosc 75: 242–253

    Article  PubMed  Google Scholar 

  27. Wallace MB, Nietert PJ, Earle C, et al. (2002) An analysis of multiple staging management strategies for carcinoma of the esophagus: computed tomography, endoscopic ultrasound, positron emission tomography and thorcoscopy/laparoscopy. Ann Thorac Surg 74: 1026–1032

    Article  PubMed  Google Scholar 

  28. Wren SM, Stijns P, Srinivas S (2002) Positron emission tomography in the initial staging of esophageal cancer. Arch Surg 137: 1001–1007

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service d’hépatogastroentérologie et nutrition, hôpital Charles-Nicolle, centre hospitalo-universitaire de Rouen, 1, rue de Germont, F-76031, Rouen cedex, France

    F. Di Fiore & P. Michel

  2. Université de Rouen, 22 boulevard Gambetta, F-76183, Rouen Cedex, France

    F. Di Fiore & P. Michel

Authors
  1. F. Di Fiore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Michel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Michel.

About this article

Cite this article

Di Fiore, F., Michel, P. Bilan préthérapeutique des cancers de la jonction oesogastrique. Oncologie 15, 144–148 (2013). https://doi.org/10.1007/s10269-013-2266-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10269-013-2266-x

Keywords

Mots clés

Search

Navigation