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Mise au point sur le lymphome testiculaire primaire

Primary testicular lymphoma: review

  • Mise Au Point / Update
  • Published:
Oncologie

Abstract

Primary testicular lymphoma is a rare form of non-Hodgkin’s lymphoma. It occurs more frequently in older patients, and it is a potentially lethal disease. For early stages (I and II), the management consists of orchidectomy followed by chemotherapy combined with monoclonal antibodies directed against the CD20 antigen and scrotal radiotherapy (sanctuary site) with/or without iliac and/or paraaortic lymph node radiotherapy. For advanced stages (III and IV), chemo-immunotherapy is the treatment of choice while scrotal radiotherapy can be discussed. Both in early or advanced disease, intrathecal chemotherapy is necessary to prevent central nervous system relapse. New molecular approaches and/or more aggressive treatments are to be explored in this rare disease.

Résumé

Le lymphome testiculaire primaire est une forme rare de lymphome malin non hodgkinien (LMNH). C’est une maladie grave touchant essentiellement le sujet âgé. Le traitement des stades précoces (I et II) repose sur l’orchidectomie suivie par la chimiothérapie (CT) associée à un anticorps monoclonal dirigé contre l’antigène CD20 et à l’irradiation scrotale (site sanctuaire) associée ou non à la radiothérapie (RT) ganglionnaire iliaque et/ou para-aortique. Dans les stades avancés (III et IV), la chimio-immunothérapie est le traitement de choix. Le rôle de la RT scrotale est sujet à controverses. La CT intrathécale (IT) est justifiée quel que soit le stade de la maladie, et ce, afin de prévenir les rechutes au niveau du système nerveux central (SNC). De nouvelles approches moléculaires et des thérapies agressives sont en voie d’exploration dans cette maladie rare.

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Authors and Affiliations

  1. Service de radio-oncologie, centre hospitalier universitaire Vaudois (CHUV), 46, rue du Bugnon, CH-1011, Lausanne, Suisse

    N. Boujelbene, S. Bhagwati, E. Herrmann, R. O. Mirimanoff, M. Ozsahin & A. Zouhair

  2. Service d’oncologie médicale, centre hospitalier universitaire Vaudois (CHUV), 46, rue du Bugnon, CH-1011, Lausanne, Suisse

    N. Ketterer

  3. Département de pathologie, institut Gustave-Roussy, F-94805, Villejuif, France

    N. Boujelbene

  4. Service de radio-oncologie, hôpital de Sion, CH-1950, Sion, Suisse

    N. Boujelbene & K. Khanfir

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  1. N. Boujelbene
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Correspondence to N. Boujelbene.

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Boujelbene, N., Ketterer, N., Boujelbene, N. et al. Mise au point sur le lymphome testiculaire primaire. Oncologie 13, 598–604 (2011). https://doi.org/10.1007/s10269-011-2029-5

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  • DOI: https://doi.org/10.1007/s10269-011-2029-5

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