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Prise en charge des ostéosarcomes de l’adulte

Management of adult osteosarcomas

  • Revue/Review
  • Published:
Oncologie

Abstract

The French National Cancer Institute encourages the organization and implementation of meetings and national structured networks dedicated to the management of rare cancers such as adult osteosarcoma. The goal is to improve the quality of care, to help obtaining specialized expertise and advice, and to promote clinical research. Professors Gouin (Orthopaedics, Nantes) and Anract (Orthopaedics, Paris) are driving this national project. This paper presents a literature review focused on the management of adult osteosarcoma and its specificities.

Résumé

L’institut national du cancer encourage la mise en place de réunions de concertation de recours et de réseaux nationaux structurés pour la prise en charge des cancers rares. Les ostéosarcomes de l’adulte sont un exemple de maladie qui entre dans cette dynamique. L’objectif est de permettre une amélioration de la qualité des soins, une facilitation de l’accès aux expertises très spécialisées et une dynamisation de la recherche clinique. Les professeurs Gouin (orthopédie, Nantes) et Anract (orthopédie, Paris) coordonnent ce projet. Cet article est une revue centrée sur la prise en charge de l’ostéosarcome de l’adulte et ses spécificités.

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Références

  1. Alexandre J, Batteux F, Nicco C, et al. (2006) Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int J Cancer. 119(1): 41–48

    Article  PubMed  CAS  Google Scholar 

  2. Alexandre J, Nicco C, Chéreau C, et al. (2006) Improvement of the therapeutic index of anticancer drugs by the SOD-mimic mangafodipir. J Natl Cancer Inst 98(4): 236–244

    Article  PubMed  CAS  Google Scholar 

  3. Anract P (1998) Biopsy In: M Forest, B Tomeno, D Vanel. Orthopedic Surgical Pathology: diagnosis of tumors and pseudotumoral lesions of bone and joint, Churchill Livingstone, Edinburgh London, New York Philadelphia San Francisco Sydney Toronto, p. 27

  4. Anract P, Biau D, Babinet A, et al. (2005) Principes du traitement chirurgical des tumeurs osseuses malignes. In: sarcomes osseux. Coord F Goldwasser. Refl Med Oncol 9(2): 10–16

    Google Scholar 

  5. Anract P, Vastel L, Tomeno B (1999) Techniques et indications des greffes et transplantations osseuses et ostéocartilagineuses. Encycl Med Chir (Elsevier, Paris) Techniques chirurgicales-Orthopédie-Traumatologie; 44-030-A: 1–14

  6. Bacci G, Mercuri M, Longhi A, et al. (2005) Grade of chemotherapy-induced necrosis as a predictor of local and systemic control in 881 patients with non-metastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy in a single institution. Eur J Cancer 41: 2079–2085

    Article  PubMed  CAS  Google Scholar 

  7. Bommer KK, Ramzy I, Mody D (1997) Fine-needle aspiration biopsy in the diagnosis and management of bone lesions: a study of 450 cases. Cancer 81(3): 148–156

    Article  PubMed  CAS  Google Scholar 

  8. Campanacci M (1986) Bone and soft tissue tumors, Springer, New York, pp. 267–304

    Google Scholar 

  9. Eilber F, Giuliano A, Eckardt J, et al. (1987) Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol 5: 21–26

    PubMed  CAS  Google Scholar 

  10. Goldwasser F (2007) Épidémiologie des cancers osseux. In: Cancers osseux. Ed P Anract. JL Libbey eurotext; pp. 1–12

  11. Goldwasser F (2007) La décision médicale en cas de cancer incurable. In: Éthique, médecine et société. Sous la direction de E Hirsch, espace éthique. Ed Vuibert, pp. 723–733

  12. Goldwasser F, Le Péchoux C, Anract P (2007) Prise en charge médicale et chirurgicale des métastases osseuses. In: Cancers osseux. Ed P Anract. JL Libbey eurotext, pp. 37–74

  13. Goldwasser F, Mir O, Alexandre J, et al. (2005) Concomitant administration of high-dose methotrexate (HDMTX) and ifosfamide in osteosarcoma patients: a clinicopharmacological study Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. Vol 23, no 16S (June 1 Supplement) 9063

    Google Scholar 

  14. Goldwasser F, Zadégan F, Hannouche D (2007) Tumeurs osseuses primitives. In: Traité de thérapeutique rhumatologique. (Ed) T Bardin et P Orcel. Flammarion Médecine-Sciences. Chap 33, pp. 267–291

  15. Laurent A, Nicco C, Chéreau C, et al. (2005) Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 65(3): 948–956

    PubMed  CAS  Google Scholar 

  16. Mankin HJ, Mankin CJ, Simon MA (1996) The hazard of the biopsy revisited. J Bone Joint Surg 78: 656–663

    PubMed  CAS  Google Scholar 

  17. Mir O, Alexandre J, Anract P, et al. (2005) Hyperalkalinization instead of hyperhydration for the prevention of high-dose methotrexate (HDMTX) induced nephrotoxicity in osteosarcoma patients. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. Vol 23, no 16S, Part I of II (June 1 Supplement): 9509

    Google Scholar 

  18. Mir O, Ropert S, Alexandre J, et al. (2007) CYP3A4/5 and pharmacogenetics in patients with sarcoma. Lancet Oncol 8(8): 667–668

    Article  PubMed  Google Scholar 

  19. Philip T, Blay JY, Brunat-Mentigny M, et al. (1999) Standards, Options and Recommendations (SOR) for diagnosis, treatment and follow-up of osteosarcoma. Groupe de travail SOR. Bull Cancer 86: 159–176

    PubMed  CAS  Google Scholar 

  20. Pierga JY, Goldwasser F (2005) La chimiothérapie de l’ostéosarcome. In: Sarcomes osseux. Coord F Goldwasser. Refl Med Oncol 9(2): 22–24

    Google Scholar 

  21. Pommier Y, Goldwasser F (2006) Topoisomerase II inhibitors: the Epipodophyllotoxins, Acridines, and Ellipticines. Chabner BA and Longo DL Ed JB Lippincott Company. (4th Ed.) In: Cancer Chemotherapy & Biotherapy. Principles and Practice. Chap. 19: 451–475.

  22. Pouillart P, Tomeno B (2005) Historique du traitement des sarcomes osseux. In: Sarcomes osseux. Coord F Goldwasser. Refl Med Oncol 9(2): 6–9

    Google Scholar 

  23. Rosen G, Murphy ML, Huvos AG, et al. (1976) Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer 37: 1–11

    Article  PubMed  CAS  Google Scholar 

  24. Souhami RL, Craft AW, Van der Eijken JW, et al. (1997) Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup. Lancet 350: 911–917

    Article  PubMed  CAS  Google Scholar 

  25. Tomeno B (1998) In: M Forest, B Tomeno, D Vanel. Orthopedic Surgical Pathology: diagnosis of tumors and pseudotumoral lesions of bone and joint, Churchill Livingstone, Edinburgh London, New York Philadelphia San Francisco Sydney Toronto, pp. 717–728

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Authors and Affiliations

  1. Service de cancérologie groupe, hospitalier Cochin-Saint-Vincent de Paul, AP-HP, 27, rue du Faubourg Saint-Jacques, F-75679, Paris cedex 14, France

    F. Goldwasser

  2. Université Paris-Descartes, Paris, France

    F. Goldwasser

  3. Service d’orthopédie, groupe hospitalier Cochin-Saint-Vincent de Paul, AP-HP, 27, rue du Faubourg Saint-Jacques, F-75679, Paris cedex 14, France

    P. Anract

  4. Université Paris-Descartes, Paris, France

    P. Anract

Authors
  1. F. Goldwasser
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  2. P. Anract
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Correspondence to F. Goldwasser or P. Anract.

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Article rédigé dans le cadre d’un appel à projet AP-HP et présenté à L’ICACT 2008.

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Goldwasser, F., Anract, P. Prise en charge des ostéosarcomes de l’adulte. Oncologie 10, 378–383 (2008). https://doi.org/10.1007/s10269-008-0910-7

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  • DOI: https://doi.org/10.1007/s10269-008-0910-7

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