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Les toxicités rénales

Nephrotoxicity of anticancer drugs

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Oncologie

Résumé

Les études épidémiologiques récentes qui s’appuient sur des critères fiables montrent que l’insuffisance rénale chronique est fréquente dans la population générale. Elle est associée à l’âge élevé, au diabète et aux maladies cardiovasculaires. Compte tenu de son caractère paucisymptomatique, elle justifie un suivi systématique et prolongé. Mêmesi la néphrotoxicité potentielle des anticancéreux est aujourd’hui mieux maitrisée, les succès des traitements, obtenus grâce à des administrations répétées, augmentent la probabilitéde survenue d’une IRC multifactorielle notamment chez les sujets âgés.

Abstract

Recent populationbased studies suggest that chronic kidney disease (CKD) with low glomerular filtration rate is frequent. Elderly, patients with diabetes or cardiovascular disease are at higher risk of CKD. As CKD symptoms are scarce, prevention of anticancer drugs nephrotoxicity and active screening for renal abnormalities are essential. As the success of modern cancer treatment requires repeated drugs delivery, the cumulative risk of CKD linked with multiple causes is still increasing.

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Références

  1. Clase CM, Garg AX, Kiberd BA (2004) Classifying kidney problems: can we avoid framing risks as diseases? BMJ 329: 912–915

    Article  PubMed  Google Scholar 

  2. Coresh J, Astor BC, Greene T, et al. (2003) Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 41: 1–12

    Article  PubMed  Google Scholar 

  3. Couchoud C, Pozet N, Labeeuw M, et al. (1999) Screening early renal failure: Cutoff values for serum creatinine as an indicator of renal impairment. Kidney Int 55: 1878–1884

    Article  CAS  PubMed  Google Scholar 

  4. Couchoud C, Moranne O, Frimat L, et al. (2007) Associations between comorbidities, treatment choice and outcome in the elderly with end-stage renal disease. Nephrol Dial Transplant (Sous presse)

  5. Frimat L, Loos C, Briançon S, et al. (2005) Epidémiologie des maladies rénales chroniques, in EMC Néphrologie, Paris, Elsevier SAS

    Google Scholar 

  6. Frimat L, Siewe G, Loos-Ayav C, et al. (2006) Insuffisance rénale chronique: le point de vue du médecin généraliste. Nephrol ther 2: 127–135

    PubMed  Google Scholar 

  7. Froissart M, Rossert J, Jacquot C, et al. (2005) Predictive Performance of the Modification of Diet in Renal Disease and Cockcroft-Gault Equations for Estimating Renal Function. J Am Soc Nephrol 16: 763–773

    Article  PubMed  Google Scholar 

  8. Halbesma N, Kuiken DS, Brantsma AH, et al. (2006) Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screening. J Am Soc Nephrol 17: 2582–2590

    Article  PubMed  Google Scholar 

  9. Isnard-Bagnis C, Moulin B, Launay-Vacher V, et al. (2005) Toxicité rénale des anticancé-reux. Nephrol Ther 1: 101–114

    PubMed  Google Scholar 

  10. Karie S, Launay-Vacher V, Izzedine H, et al. (2006) Toxicitédes médicaments: veille bibliographique janvier 2003 — décembre 2005. Nephrol Ther 2: 368–378

    CAS  PubMed  Google Scholar 

  11. Kouchner B (2002) Insuffisance rénale chronique: vers une politique de santé publique. Presse Med 31: 165–166

    CAS  PubMed  Google Scholar 

  12. Launay-Vacher V, Izzedine H, Rey JB, et al. (2004) Incidence of renal insufficiency in cancer patients and evaluation of information available on the use of anticancer drugs in renally impaired patients. Med Sci Monit 10: 209–212

    Google Scholar 

  13. Levey AS, Coresh J, Balk E, et al. (2003) National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. Ann Intern Med 139: 137–47

    PubMed  Google Scholar 

  14. Lichtman SM, Wildiers H, Launay-Vacher V, et al. (2007) InternationalSociety ofGeriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. Eur J Cancer 43: 14–34

    Article  PubMed  Google Scholar 

  15. Macron-Noguès F, Vernay M, Ekong E, et al. (2005) The prevalence of end-stage kidney disease treated with renal dialysis in France in 2003. Am J Kidney Dis 46: 309–15

    Article  PubMed  Google Scholar 

  16. Markowitz GS, Fine PL, Stack JI, et al. (2003) Toxic acute tubular necrosis following treatment with zoledronate. Kidney Int 64: 281–9

    Article  CAS  PubMed  Google Scholar 

  17. Rule AD, Larson TS, Bergstralh EJ, et al. (2004) Using Serum Creatinine To Estimate Glomerular Filtration Rate: Accuracy in Good Health and in Chronic Kidney Disease. Ann Intern Med 141: 929–37

    CAS  PubMed  Google Scholar 

  18. Stengel B, Couchoud C (2006) Chronic kidney disease prevalence and treated end-stage renal disease incidence: A complex relationship. J Am Soc Nephrol 17: 2094–6

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Département de néphrologie, CHU de Nancy, Nancy universités, Hôpitaux de Brabois, 54500, Vandœuvre-les-Nancy, France

    L. Frimat

  2. Service d’oncologie médicale, Centre Alexis Vautrin, 54511, Vandoeuvre-les-Nancy cedex, France

    I. Krakowski

Authors
  1. L. Frimat
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  2. I. Krakowski
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Correspondence to L. Frimat.

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Frimat, L., Krakowski, I. Les toxicités rénales. Oncologie 9 (Suppl 3), HS11–HS15 (2007). https://doi.org/10.1007/s10269-007-0741-y

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  • DOI: https://doi.org/10.1007/s10269-007-0741-y

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