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Infertilité postchimiothérapie

Infertility after chemotherapy

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  • Published:
Oncologie

Résumé

Le risque d’infertilité, par le biais de la gonadotoxicitédes chimiothérapies, estunedes séquelles à long terme majeures chez les enfants, lesadolescentset lesjeunes adultes. Ce risque diffère selon l’âge et lesexedespatientsaumomentdu traitement, leschémathérapeutique et les associations de médicaments cytotoxiques utilisées. Les alkylants sont lesmédicaments les plus gonadotoxiques, avec une stérilité définitive quand ils sont utilisés dans des schémas d’intensification thérapeutique. L’évaluationdes « dégâts » de la chimiothérapie sur les gonades faitpartiedusuividespatients, qu’ils aient été traités dans l’enfance, l’adolescence ou à l’âge adulte en âge de procréer, et est particuliè rement difficile chez les femmes. Les deuxseules techniques de préservation de la fertilité éprouvées sont, chez l’homme pubère, la cryoconservation de sperme et, chez la femme pubère, la cryoconservation d’embryons obtenus par fécondation in vitro; les autres techniques étant en cours d’évaluation.

Abstract

The risk of infertility is one of the most challenging long-term sequels of cancer chemotherapy in children and young adults. This risk depends on the patient’s age, sex and drug regimen. Alkylating agents are the most gonadotoxic drugs, especially when administered in high-dose regimen before haematopoietic stem cell injections. The evaluation of gonadal damage must be part of the long-term follow-up strategy for cancer patients and might be difficult in female patients. While sperm and embryo cryopreservation are well established and successful in fertility preservation, others technologies are still in their early stages of development.

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Authors and Affiliations

  1. Département d’oncologie médicale, institut Curie, 26, rue d’Ulm, F-75005, Paris, France

    V. Laurence

  2. Groupe hospitalier de la Pitié-Salpêtrière, UF de biologie de la reproduction, 83, boulevard de l’Hôpital, F-75013, Paris, France

    C. Poirot

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  1. V. Laurence
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  2. C. Poirot
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Correspondence to V. Laurence.

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Laurence, V., Poirot, C. Infertilité postchimiothérapie. Oncologie 9 (Suppl 3), HS21–HS25 (2007). https://doi.org/10.1007/s10269-007-0739-5

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  • DOI: https://doi.org/10.1007/s10269-007-0739-5

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