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Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?

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Abstract

To investigate the relationship between apical periodontitis [AP] severity and inflammatory markers [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-α), and Mid-Regional Pro Adrenomedullin (MR-proADM)] in patients with AP. A total of 162 subjects were divided into three categories: AP group (n = 80), periodontitis (P) group (n = 42), healthy control group (n = 40). The scoring of disease severity in 80 AP patients without any periodontal disease, using dental radiographs, was based on “The Abscess Score” (AS), as those having at least 1 tooth with AP and severity of PAI 3–4 were classified as AS 1 (mild); those with only1 tooth and severity of PAI 5 as AS 2 (moderate) and those having > 2 tooth with severity of PAI 5 as AS 3 (severe). Blood samples were collected from all of the patients. Enzyme-linked immunosorbent assay was used to evaluate the samples. The MR-pro ADM levels of both the AP and P groups were considerably higher than the control group (p < 0.01). The IL-12 levels of the AP group were higher than the P and control groups (p < 0.05). TNF-α levels of the P group were significantly higher than both the AP and control groups (p < 0.01). MR-pro ADM levels of both the AP and Periodontitis groups were higher than the control group. TNF-α was a biomarker of periodontitis, while IL-12 was a biomarker of apical periodontitis.

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Data Availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

All authors contributed equally to all study design, data collection, statistical analysis, data interpretation, manuscript preparation, and literature search. We would want to thank Dr. Batuhan Akca and Dr. Hasan Alp Topcu for their support during the English editing of our article.

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Authors and Affiliations

  1. Department of Endodontics, Faculty of Dentistry, Istanbul Medipol University, Esenler Hastanesi, Birlik Mah. Bahçeler Cad. No: 5 Esenler, Istanbul, Turkey

    Seyda Ersahan & Yelda Erdem Hepsenoglu

  2. Faculty of Medicine, Medical Biochemistry Department, University of Health Sciences, Istanbul, Turkey

    Fatih Ozcelik

  3. Faculty of Dentistry, Department of Endodontics, University of Health Sciences, Istanbul, Turkey

    Dursun Ali Sirin & Celalettin Topbas

  4. Faculty of Medicine, Istinye University, Istanbul, Turkey

    Ilbey Kayra Ozcelik

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  1. Seyda Ersahan
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Correspondence to Seyda Ersahan.

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This research has been conducted in full accordance with ethical principles, including the World Medical Association Declaration of Helsinki (version 2008). All interventions were undertaken with the understanding and written consent of each participant and according to the above-mentioned principles. The study has been independently reviewed and approved by an ethical board.

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Ersahan, S., Ozcelik, F., Sirin, D.A. et al. Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?. Odontology 111, 708–718 (2023). https://doi.org/10.1007/s10266-022-00767-9

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