Skip to main content

Occlusal problems, mental health issues and non-carious cervical lesions

Abstract

Non-carious cervical lesions (NCCLs) are characterized by a loss of hard dental tissue near the cement–enamel junction with multifactorial etiology. The aim of this study was to demonstrate that occlusal factors as attrition, malocclusion, and bruxism, and mental disorders as depression, stress, and anxiety are involved in the etiology of NCCLs. Salivary samples and clinical data of 340 individuals selected from 6,112 participants were obtained from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository project. The affected group was formed by individuals with NCCL (34 females, 34 males, mean age 55.34 years). In addition, the comparison group was formed by individuals without NCCL (136 females, 136 males, mean age 55.14 years). Eleven single-nucleotide polymorphisms (SNPs) previously associated with mental disorders were genotyped and tested for association with NCCLs. When all occlusal factors were combined there was found a significant association with NCCL (p = 0.000001/adjusted OR 4.38, 95% CI 2.50–7.69). Attrition (OR 3.56, 95% CI 2.00–6.32) and malocclusion (OR 5.09, 95% CI 1.65–15.68) as separate variables showed statistically significant associations with NCCL. There was a significant difference in stress history between the two groups (OR 2.17, 95% CI 1.08–4.39). No associations between NCCLs and the SNPs selected were found. However, when the occlusal factors were analyzed as covariates, associations were found between bruxism and seven of the selected SNPs. Our results suggest that occlusal factors might be associated with NCCLs.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Ceruti P, Menicucci G, Mariani GD, Pittoni D, Gassino G. Non carious cervical lesions. A review. Minerva Stomatol. 2006;55:43–57.

    PubMed  Google Scholar 

  2. 2.

    Wood I, Jawad Z, Paisley C, Brunton P. Non-carious cervical tooth surface loss: A literature review. J Dent. 2008;36:759–66.

    Article  Google Scholar 

  3. 3.

    Ibrahim KG, Abubakr NH, Ibrahim YE. Prevalence of dental abfraction among a sample of Sudanese patients. Arch Orofac Sci. 2012;7:50–5.

    Google Scholar 

  4. 4.

    Handa A, Bal CS, Singh R, Khanna R, Handa RS. The prevalence of non-carious cervical lesions (NCCLS) in a North-Indian population. IJCDC. 2014;4:416–21.

    Google Scholar 

  5. 5.

    Jafari Z. The study of possible factors related to non-carious cervical lesions. EJAE. 2014;1:45–8.

    Google Scholar 

  6. 6.

    Kolak V, Pešić D, Melih I, Lalović M, Nikitović A, Jakovljević A. Epidemiological investigation of non-carious cervical lesions and possible etiological factors. J Clin Exp Dent. 2018;10:648–56.

    Google Scholar 

  7. 7.

    Igarashi Y, Yoshida S, Kanazawa E. The prevalence and morphological types of non-carious cervical lesions (NCCL) in a contemporary sample of people. Odontology. 2017;105:1–10. https://doi.org/10.1007/s10266-017-0300-y.

    Article  Google Scholar 

  8. 8.

    Borcic J, Anic I, Urek MM, Ferreri S. The prevalence of non-carious cervical lesions in permanent dentition. J Oral Rehabil. 2004;31:117–23.

    Article  Google Scholar 

  9. 9.

    Grippo JO, Simring M, Coleman TA. Abfraction, abrasion, biocorrosion, and the enigma of noncarious cervical lesions: a 20 year perspective. J Esthet Restor Dent. 2012;24:10–25.

    Article  Google Scholar 

  10. 10.

    Khan F, Young WG, Shahabi S, Daley TJ. Dental cervical lesions associated with occlusal erosion and attrition. Aust Dent J. 1999;44:176–86.

    Article  Google Scholar 

  11. 11.

    Duangthip D, Man A, Poon PH, Lo ECM, Chu CH. Occlusal stress is involved in the formation of non-carious cervical lesions. A systematic review of abfraction. Am J Dent. 2017;30:212–20.

    PubMed  Google Scholar 

  12. 12.

    Soares PV, Grippo JO. Lesões cervicais não cariosas e hipersensibilidade dentinária cervical. In: Etiologia, diagnóstico e tratamento. São Paulo: Quintessense Publishing; 2017.

    Google Scholar 

  13. 13.

    de Castilho LS, Abreu MH, de Oliveira RB, Souza ESME, Resende VL. Factors associated with mouth breathing in children with developmental disabilities. Spec Care Dentist. 2016;36:75–9.

    Article  Google Scholar 

  14. 14.

    Oliveira MT, Bittencourt ST, Marcon K, Destro S, Pereira JR. Sleep bruxism and anxiety level in children. Braz Oral Res. 2015;29:1–5.

    PubMed  Google Scholar 

  15. 15.

    Manfredini D, Serra-Negra J, Carboncini F, Lobbezoo F. Current concepts of bruxism. Int J Prosthodont. 2017;30:437–8.

    Article  Google Scholar 

  16. 16.

    Castrillon EE, Ou KL, Wang K, Zhang J, Zhou X, Svensson P. Sleep bruxism: an updated review of an old problem. Acta Odontol Scand. 2016;74:328–34.

    Article  Google Scholar 

  17. 17.

    Brandini DA, Pedrini D, Panzarini SR, Benete IM, Trevisan CL. Clinical evaluation of the association of noncarious cervical lesions, parafunctional habits, and TMD diagnosis. Quintessence Int. 2012;43:255–62.

    PubMed  Google Scholar 

  18. 18.

    De Roo MJ, Van Vuren RF. More attention needed to side effects on teeth: Dental problems caused by psychotropics. Pharm Weekbl. 2010;145:26–7.

    Google Scholar 

  19. 19.

    Souza VA, Abreu MH, Resende VL, Castilho LS. Factors associated with bruxism in children with developmental disabilities. Braz Oral Res. 2015;29:1–5.

    Article  Google Scholar 

  20. 20.

    Monaco A, Ciammella NM, Marci MC, Pirro R, Giannoni M. The anxiety in bruxer child. A case-control study. Minerva Stomatol. 2002;51:247–50.

    PubMed  Google Scholar 

  21. 21.

    Oporto GHt, Bornhardt T, Iturriaga V, Salazar LA. Genetic polymorphisms in the serotonergic system are associated with circadian manifestations of bruxism. J Oral Rehabil. 2016;43:805–12.

    Article  Google Scholar 

  22. 22.

    Hennessy S, Bilker WB, Berlin JA, Strom BL. Factors influencing the optimal control-to-case ratio in matched case-control studies. Am J Epidemiol. 1999;149:195–7.

    Article  Google Scholar 

  23. 23.

    Aidar M, Line SR. A simple and cost-effective protocol for DNA isolation from buccal epithelial cells. Braz Dent J. 2007;18:148–52.

    Article  Google Scholar 

  24. 24.

    Ranade K, Chang MS, Ting CT, Pei D, Hsiao CF, Olivier M, Pesich R, Hebert J, Chen YD, Dzau VJ, et al. High-throughput genotyping with single nucleotide polymorphisms. Genome Res. 2001;11:1262–8.

    PubMed  PubMed Central  Google Scholar 

  25. 25.

    Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, Hetmanski JB, Liang KY, Wu T, Murray T, Fallin MD, Redett RA, Raymond G, Schwender H, Jin SC, Cooper ME, Dunnwald M, Mansilla MA, Leslie E, Bullard S, Lidral AC, Moreno LM, Menezes R, Vieira AR, Petrin A, Wilcox AJ, Lie RT, Jabs EW, Wu-Chou YH, Chen PK, Wang H, Ye X, Huang S, Yeow V, Chong SS, Jee SH, Shi B, Christensen K, Melbye M, Doheny KF, Pugh EW, Ling H, Castilla EE, Czeizel AE, Ma L, Field LL, Brody L, Pangilinan F, Mills JL, Molloy AM, Kirke PN, Scott JM, Arcos-Burgos M, Scott AF. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet. 2010;42(6):525–9. https://doi.org/10.1038/ng.580.(Epub 2010 May 2. Erratum. In: Nat Genet. 2010 Aug; 42(8):727. Scott, James M [corrected to Scott, John M]. PMID: 20436469; PMCID: PMC2941216)

    Article  PubMed  PubMed Central  Google Scholar 

  26. 26.

    Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, et al. Plink: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–75.

    Article  Google Scholar 

  27. 27.

    Grippo JO, Simring M. Dental ‘erosion’ revisited. J Am Dent Assoc. 1995;126:619–20 (623–4, 627–30).

    Article  Google Scholar 

  28. 28.

    Sperber GH. Dental wear: attrition, erosion, and abrasion—a palaeo-odontological approach. Dent J. 2017;17:5. https://doi.org/10.3390/dj5020019.

    Article  Google Scholar 

  29. 29.

    Gardette V, Coley N, Toulza O, Andrieu S. Attrition in geriatric research: how important is it and how should it be dealt with? J Nutr Health Aging. 2007;11:265–71.

    PubMed  Google Scholar 

  30. 30.

    Manfredini D, Winocur E, Guarda-Nardini L, Paesani D, Lobbezoo F. Epidemiology of bruxism in adults: a systematic review of the literature. J Orofac Pain. 2013;27(2):99–110. https://doi.org/10.11607/jop.921.

    Article  PubMed  Google Scholar 

  31. 31.

    Castroflorio T, Bargellini A, Rossini G, Cugliari G, Deregibus A, Manfredini D. Agreement between clinical and portable EMG/ECG diagnosis of sleep bruxism. J Oral Rehabil. 2015;42:759–64. https://doi.org/10.1111/joor.12320.

    Article  PubMed  Google Scholar 

  32. 32.

    Lavigne GJ, Rompré PH, Montplaisir JY. Sleep bruxism: validity of clinical research diagnostic criteria in a controlled polysomnographic study. J Dent Res. 1996;75:546–52.

    Article  Google Scholar 

  33. 33.

    Que K, Guo B, Jia Z, Chen Z, Yang J, Gao P. A cross-sectional study: non-carious cervical lesions, cervical dentine hypersensitivity and related risk factors. J Oral Rehabil. 2013;40:24–32.

    Article  Google Scholar 

  34. 34.

    Alvarez-Arenal A, Alvarez-Menendez L, Gonzalez-Gonzalez I, Alvarez-Riesgo JA, Brizuela-Velasco A, deLlanos-Lanchares H. Non-carious cervical lesions and risk factors: a case-control study. J Oral Rehabil. 2019;46:65–75. https://doi.org/10.1111/joor.12721.

    Article  PubMed  Google Scholar 

  35. 35.

    Litonjua LA, Bush PJ, Andreana S, Tobias TS, Cohen RE. Effects of occlusal load on cervical lesions. J Oral Rehabil. 2004;31:225–32.

    Article  Google Scholar 

  36. 36.

    Tsiggos N, Tortopidis D, Hatzikyriakos A, Menexes G. Association between self-reported bruxism activity and occurrence of dental attrition, abfraction, and occlusal pits on natural teeth. J Prosthet Dent. 2008;100:41–6.

    Article  Google Scholar 

  37. 37.

    Jonsgar C, Hordvik PA, Berge ME, Johansson AK, Svensson P, Johansson A. Sleep bruxism in individuals with and without attrition-type tooth wear: an exploratory matched case-control electromyographic study. J Dent. 2015;43:1504–10. https://doi.org/10.1016/j.jdent.2015.10.002.

    Article  PubMed  Google Scholar 

  38. 38.

    Johansson A, Johansson AK, Omar R, Carlsson GE. Rehabilitation of the worn dentition. J Oral Rehabil. 2008;35:548–66. https://doi.org/10.1111/j.1365-2842.2008.01897.x.

    Article  PubMed  Google Scholar 

  39. 39.

    Johansson AK, Omar R, Carlsson GE, Johansson A. Dental erosion and its growing importance in clinical practice: from past to present. Int J Dent. 2012;2012: 632907. https://doi.org/10.1155/2012/632907.

    Article  PubMed  PubMed Central  Google Scholar 

  40. 40.

    Kampe T, Edman G, Bader G, Tagdae T, Karlsson S. Personality traits in a group of subjects with long-standing bruxing behaviour. J Oral Rehabil. 1997;24:588–93.

    Article  Google Scholar 

  41. 41.

    Suppli NP, Bukh JD, Moffitt TE, Caspi A, Johansen C, Tjønneland A, Kessing LV, Dalton SO. Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis. Depress Anxiety. 2017;34:845–55. https://doi.org/10.1002/da.22660.

    Article  PubMed  PubMed Central  Google Scholar 

  42. 42.

    Elwood J, Murray E, Bell A, Sinclair M, Kernohan WG, Stockdale J. A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression. J Affect Disord. 2019;253:51–62. https://doi.org/10.1016/j.jad.2019.04.059.

    Article  PubMed  Google Scholar 

  43. 43.

    de Vries PJ, Belousova E, Benedik MP, et al. TSC-associated neuropsychiatric disorders (TAND): findings from the TOSCA natural history study. Orphanet J Rare Dis. 2018;13:157. https://doi.org/10.1186/s13023-018-0901-8.

    Article  PubMed  PubMed Central  Google Scholar 

  44. 44.

    Li Q, Michaud M, Shankar R, Canosa S, Schwartz M, Madri JA. MMP-2: a modulator of neuronal precursor activity and cognitive and motor behaviors. Behav Brain Res. 2017;333:74–82. https://doi.org/10.1016/j.bbr.2017.06.041.

    Article  PubMed  Google Scholar 

  45. 45.

    McGregor NW, Dimatelis JJ, Van Zyl PJ, Hemmings SMJ, Kinnear C, Russell VA, Stein DJ, Lochner C. A translational approach to the genetics of anxiety disorders. Behav Brain Res. 2018;341:91–7. https://doi.org/10.1016/j.bbr.2017.12.030.

    Article  PubMed  Google Scholar 

  46. 46.

    Ramírez-Bello J, Jiménez-Morales M. Implicaciones funcionales de los polimorfismos de un solo nucleótido (SNP) en genes codificantes de proteínas y no codificantes en enfermedades multifactoriales [functional implications of single nucleotide polymorphisms (SNPs) in protein-coding and non-coding RNA genes in multifactorial diseases]. Gac Med Mex. 2017;153(2):238–50.

    PubMed  Google Scholar 

Download references

Funding

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

Author information

Affiliations

Authors

Contributions

BLN: Research conception and design, acquisition of data, analysis and interpretation of data, drafting the manuscript. ARV: Manuscript review, agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. MB: Contributions to conception and design, acquisition, analysis and interpretation of genetic data. SAI: Analysis and interpretation of data. EMS: Research conception and design, drafting the manuscript, final approval of the version to be published.

Corresponding author

Correspondence to Evelise M. Souza.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Data for the study were obtained from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA repository project. The study protocol was approved by the University of Pittsburgh Institutional Review Board.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Nascimento, B.L., Vieira, A.R., Bezamat, M. et al. Occlusal problems, mental health issues and non-carious cervical lesions. Odontology (2021). https://doi.org/10.1007/s10266-021-00658-5

Download citation

Keywords

  • Dental occlusion
  • Bruxism
  • Depression
  • Anxiety
  • Polymorphism genetic