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Volatile sulphur compounds in people with chronic kidney disease and the impact on quality of life

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Abstract

The objectives are to identify volatile sulphur compounds (VSCs) in individuals with Chronic Kidney Disease (CKD) and to relate quality of life and oral health. A case–control study with 32 individuals with CKD in haemodialysis in the study group (SG) and 32 healthy individuals in the control group (CG) was performed. The VSCs were identified by gas chromatograph before (BC) and after cysteine (AC) mouthwash and an organoleptic test. For oral health assessment, oral health index was used. For quality of life, the Oral Health Impact Profile (OHIP-14) and Medical Outcomes Study 36-Item Short Form Health Survery (SF-36) were used. The hydrogen sulphide AC, methyl mercaptan AC, tongue coating, dry mouth, plaque index, and DMFT were significantly higher in the SG. VSCs did not negatively affected the impact of oral health on the quality of life in the SG but did in the CG. As for the impact of general health on quality of life, methyl mercaptan BC and AC worsened overall health in vitality and mental health, respectively. Individuals with CKD have more halitosis than healthy individuals, and it is more related to methyl mercaptan. The halitosis worsened the general quality of life of individuals with CKD. The diagnosis and identification of the origin of halitosis is important to prevent one more factor that it worsened the global quality of life of patients with CKD.

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References

  1. Aydin M, Harvey-Woodworth CN. Halitosis: a new definition and classification. Br Dent J. 2014;217:E1. https://doi.org/10.1038/sj.bdj.2014.552.

    Article  PubMed  Google Scholar 

  2. Tangerman A, Winkel EG. Extra-oral halitosis: an overview. J Breath Res. 2010;4:017003. https://doi.org/10.1088/1752-7155/4/1/017003.

    Article  PubMed  Google Scholar 

  3. Bollen CML, Bleikler T. Halitosis: the multidisciplary approach. Int J Oral Sci. 2012;4:55–63. https://doi.org/10.1038/ijos.2012.39.

    Article  PubMed  PubMed Central  Google Scholar 

  4. van den Broek AM, Feenstra L, de Baat C. A review of the current literature on aetiology and measurement methods of halitosis. J Dent. 2007;35:327–35. https://doi.org/10.1016/j.jdent.2007.04.009.

    Article  Google Scholar 

  5. Gulsahi A, Evirgen S, Öztaş B, et al. Volatile súlfur compunds levels and related factors in patients with chronic renal failure. J Clin Periodontol. 2014;41:814–9. https://doi.org/10.1111/jcpe.

    Article  PubMed  Google Scholar 

  6. Quirynen M, Zhao H, Avontroodt P, et al. A salivary incubation test for evaluation of oral malodor: a pilot study. J Periodontol. 2003;74:937–44. https://doi.org/10.1902/jop.2003.74.7.937.

    Article  PubMed  Google Scholar 

  7. Tarzia O. Halitose: um desafio que tem cura. Rio de Janeiro: EPUB; 2003.

    Google Scholar 

  8. World Health Organization (2013). Oral Health Surveys Basic Methods. 5th editon. https://www.who.int/oral_health/publications/9789241548649/en/

  9. Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967;38(Suppl):610–6. https://doi.org/10.1902/jop.1967.38.6.610.

    Article  Google Scholar 

  10. Silness J, LöeH H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964;22:121–35. https://doi.org/10.3109/00016356408993968.

    Article  PubMed  Google Scholar 

  11. Winkel EG, Roldán S, Van Winkelhoff AJ, et al. Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis: a dual-center, double-blind placebo-controlled study. J Clin Periodontol. 2003;30:300–6. https://doi.org/10.1034/j.1600-051x.2003.00342.x.

    Article  PubMed  Google Scholar 

  12. Flink H, Bergdahl M, Tegelberg A, et al. Prevalence of hyposalivation in relation to general health, body mass index and remaining teeth in diferente age groups of adults. Community Dent Oral Epidemiol. 2008;36:523–31. https://doi.org/10.1111/j.1600-0528.2008.00432.x.

    Article  PubMed  Google Scholar 

  13. Albuquerque DF, de Souza TE, Amado FM, et al. Evaluation of halitosis and sialometry in patients submitted to head and neck radiotherapy. Med Oral Patol Oral Cir Bucal. 2010;15:e850–4. https://doi.org/10.4317/medoral.15.e850.

    Article  PubMed  Google Scholar 

  14. Kleinberg I, Codipilly D. H(2)S generation and E(h) reduction in cysteine challenge testing as a means of determining the potential of test products and treatments for inhibiting oral malodor. J Breath Res. 2008;2:017018. https://doi.org/10.1088/1752-7155/2/1/017018.

    Article  PubMed  Google Scholar 

  15. Aimetti M, Perotto S, Castiglione A, et al. Prevalence estimation of halitosis and its association with oral health-related parameters in an adult population of a city in North Italy. J Clin Periodontol. 2015;42:1105–14. https://doi.org/10.1111/jcpe.12474.

    Article  PubMed  Google Scholar 

  16. Shimura M, Yasuno Y, Iwakura M, et al. A new monitor with a zinc-oxide film semiconductor sensor for the measurement of volatile súlfur compounds in mouth air. J Periodontol. 1996;67:396–402. https://doi.org/10.1902/jop.1996.67.4.396.

    Article  PubMed  Google Scholar 

  17. Thomson WM. Measuring change in dry-mouth symptoms over time using the Xerostomia Inventory. Gerodontology. 2007;24:30–5. https://doi.org/10.1111/j.1741-2358.2007.00137.x.

    Article  PubMed  Google Scholar 

  18. Slade GD. Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol. 1997;25:284–90. https://doi.org/10.1111/j.1600-0528.1997.tb00941.x.

    Article  PubMed  Google Scholar 

  19. Oliveira BH, Nadanovky P. Psychometric properties of the Brazilian version of the Oral Health Impact Profile-short form. Community Dent Oral Epidemiol. 2005;33:307–14. https://doi.org/10.1111/j.1600-0528.2005.00225.x.

    Article  PubMed  Google Scholar 

  20. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473–83.

    Article  Google Scholar 

  21. Ciconelli RM, Ferraz MB, Santos W, et al. Brazilian-Portuguese version of the SF-36. A reliable and valid quality of life outcome measure. Rev Bras Reumatol. 1999;39:143–50.

    Google Scholar 

  22. Talebian A, Tazhibi M, Iranpoor R, et al. Relationship between tonsil odor and oral malodor: a clinical study on 48 Iranian patients. J Breath Res. 2008;2:017016. https://doi.org/10.1088/1752-7155/2/1/017016.

    Article  PubMed  Google Scholar 

  23. Vandekerckhove B, Van den Velde S, De Smit M, et al. Clinical reliability of non-organoleptic oral malodour measurements. J Clin Periodontol. 2009;36:964–9. https://doi.org/10.1111/j.1600-051X.2009.01473.x.

    Article  PubMed  Google Scholar 

  24. Oyetola EO, Owotade FJ, Agbelusi GA, et al. Salivary flow rates of Nigerian patients with chronic kidney disease: a case-control study. J Contemp Dent Pract. 2015;16:264–9. https://doi.org/10.5005/jp-journals-10024-1673.

    Article  PubMed  Google Scholar 

  25. López-Pintor RM, López-Pintor L, Casañas E, et al. Risk factors associated with xerostomia in haemodialysis patients. Med Oral Patol Oral Cir Bucal. 2017;22:e185–92. https://doi.org/10.4317/medoral.21612.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Hajian-Tilaki A, Oliae F, Jenabian N, et al. Oral health-related quality of life and periodontal and dental health status in Iranian hemodialysis patients. J Contemp Dent Pract. 2014;15:482–90. https://doi.org/10.5005/jp-journals-10024-1566.

    Article  PubMed  Google Scholar 

  27. Lu HX, Chen XL, Wong M, et al. Oral health impact of halitosis in Chinese adults. Int J Dent Hyg. 2017;15:e85–92. https://doi.org/10.1111/idh.12242.

    Article  PubMed  Google Scholar 

  28. Kizhner V, Xu D, Krespi YP. A new tool measuring oral malodor quality of life. Eur Arch Otorhinolaryngol. 2011;268:1227–32. https://doi.org/10.1007/s00405-011-1518-x.

    Article  PubMed  Google Scholar 

  29. Durham J, Fraser HM, McCracken GI, et al. Impact of periodontitis on oral health-related quality of life. J Dent. 2013;41:370–6. https://doi.org/10.1016/j.jdent.2013.01.008.

    Article  PubMed  Google Scholar 

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Acknowledgements

We thank the nephrologist Tricya Nunes Vieira Bueloni for her encouragement and availability in this research

Funding

This study was financed by the Coordination for the improvement of Higher Education Personnel-Brasil (CAPES)-Finance Code 001.

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Authors and Affiliations

  1. Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo (FOB-USP), Alameda Octávio Pinheiro Brisola, 9-75, Vila Universitária, Bauru, SP, 17012-901, Brazil

    Natalia Garcia Santaella, Guilherme Simpione, Aloizio Premoli Maciel & Paulo Sérgio da Silva Santos

  2. Department of Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisola, 9-75, Vila Universitária, Bauru, SP, 17012-901, Brazil

    José Roberto Lauris

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  1. Natalia Garcia Santaella
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  2. Guilherme Simpione
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  4. José Roberto Lauris
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  5. Paulo Sérgio da Silva Santos
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Correspondence to Natalia Garcia Santaella.

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Conflict of interest

Author Natalia Garcia Santaella declares that she has conflict of interest. Author Guilherme Simpione declares that he has conflict of interest. Author Aloizio Premoli Maciel declares that he has conflict of interest. Author José Roberto Lauris declares that he has conflict of interest. Author Paulo Sérgio da Silva Santos declares that he has conflict of interest. The entity with whom they have such a relationship and the nature of them potential conflict is: Odomed.

Ethical approval

All procedures performed in the participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This research was approved by the Research Ethics Committee under CAEE 71651517.9.000.5417.

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Informed consent was obtained from all individual participants included in the study.

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Santaella, N.G., Simpione, G., Maciel, A.P. et al. Volatile sulphur compounds in people with chronic kidney disease and the impact on quality of life. Odontology 109, 561–567 (2021). https://doi.org/10.1007/s10266-020-00576-y

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  • DOI: https://doi.org/10.1007/s10266-020-00576-y

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