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Evaluation of a new tricalcium phosphate for guided bone regeneration: an experimental study in the beagle dog

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Abstract

This study compared the in vivo behavior of two biomaterials, xenograft (Bio-Oss®) and alloplastic tricalcium phosphate (Sil-Oss®), vs a control (no biomaterial) in beagle dogs treated with guided bone regeneration (GBR). Six male adult beagle dogs were included. The third and fourth mandibular premolars and first mandibular molars (3P3, 4P4 and 1M1) on both sides were extracted. After 12 weeks of healing, Straumann implants (3.3 × 8 mm) were placed, performing standardized defects (3.3 × 6 mm) in the vestibular aspect of the alveolar bone. The defects were surgically treated by randomized placement of xenograft (Bio-Oss®), alloplastic tricalcium phosphate (Sil-Oss®) or no biomaterial and covered with a resorbable collagen membrane (BioGide®). After an additional 12-week healing period, the lower jaws were dissected. Total area regenerated in the region of interest, total volume, bone to implant contact in the regenerated area, and volumetric changes were measured through histological, histomorphometrical and microcomputed tomography (microCT) techniques. The negative control group showed bone ingrowth inside the defect, with a partial collapse of the buccal bone. This was not observed in the biomaterial-treated groups. Defects treated with the xenograft showed 51.40% (SD 19.83) newly mineralized tissue, while those treated with alloplastic tricalcium showed 62.54% (SD 11.54) newly mineralized tissue; the control showed 71.52% (SD 6.46). Alloplastic tricalcium phosphate modified with monetite and zinc showed similar features in alveolar regeneration of defects to those treated with the xenograft or conventional GBR, but it showed an ideally higher rate of new mineralized tissue formation and accelerated resorption.

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Funding

This study has been partially supported by grants from Ministry of Economy and Competitiveness (Ref. RTC-2014-1731-1). The funders had no role in the study design, data collection and analysis, decision to publish, or in the preparation of the manuscript.

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Authors and Affiliations

  1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Universidade de Santiago de Compostela, Entrerríos s/n, 15782, Santiago de Compostela, Spain

    Mario Pérez-Sayáns, Alejandro I. Lorenzo-Pouso, Manuel Somoza-Martín, Mercedes Gallas-Torreira & Abel García-García

  2. Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

    Mario Pérez-Sayáns, Alejandro I. Lorenzo-Pouso & Abel García-García

  3. Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, Granada, Spain

    Pablo Galindo-Moreno

  4. Department of Veterinary Clinical Sciences, University of Santiago de Compostela, Lugo, Spain

    Fernando Muñoz-Guzón, Antonio González-Cantalapiedra & Mónica López-Peña

Authors
  1. Mario Pérez-Sayáns
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  2. Alejandro I. Lorenzo-Pouso
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  3. Pablo Galindo-Moreno
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  4. Fernando Muñoz-Guzón
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  5. Antonio González-Cantalapiedra
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  6. Mónica López-Peña
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  7. Manuel Somoza-Martín
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  8. Mercedes Gallas-Torreira
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  9. Abel García-García
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Correspondence to Mario Pérez-Sayáns.

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Pérez-Sayáns, M., Lorenzo-Pouso, A.I., Galindo-Moreno, P. et al. Evaluation of a new tricalcium phosphate for guided bone regeneration: an experimental study in the beagle dog. Odontology 107, 209–218 (2019). https://doi.org/10.1007/s10266-018-0384-z

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  • DOI: https://doi.org/10.1007/s10266-018-0384-z

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